A5046996095- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Adverse Reactions
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- Infant Health and Development
- Respiratory viral infections research
- Immune responses and vaccinations
- Pharmaceutical studies and practices
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- COVID-19 Pandemic Impacts
- Diabetes and associated disorders
- Child Nutrition and Feeding Issues
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
Hospital for Sick Children
2016-2025
University of Toronto
2016-2025
SickKids Foundation
2016-2025
Canada Research Chairs
2024
University of Colorado Denver
2023
University of California, Los Angeles
2023
University of California, San Francisco
2023
University of California, San Diego
2023
Children's Hospital Colorado
2023
Stanford University
2023
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than quarter the consists probable mobile or foreign DNA. One predicted elements is previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing plasmids, one encoding undescribed pheromone inhibitor. apparent propensity for incorporation probably contributed to rapid acquisition and dissemination drug...
Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in blood cells. Here we show a child microthrombocytopenia, eosinophilia and inflammatory disease, homozygous frameshift mutation (p.Val91Trpfs*30). Platelet lysates reveal no greatly reduced Arp2/3 complex. Missense mutations are identified an unrelated patient similar symptoms deficiency. ARPC1B-deficient platelets...
No approved treatment for peanut allergy exists children younger than 4 years of age, and the efficacy safety epicutaneous immunotherapy with a patch in toddlers are unknown. We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving 1 to 3 age confirmed by food challenge. Patients who had an eliciting dose (the necessary elicit allergic reaction) 300 mg or less protein were assigned 2:1 ratio receive delivered means (intervention group) placebo...
Background & AimsA proportion of infants and young children with inflammatory bowel diseases (IBDs) have subtypes associated a single gene variant (monogenic IBD). We aimed to determine the prevalence monogenic disease in cohort pediatric patients IBD.MethodsWe performed whole-exome sequencing analyses blood samples from an unselected 1005 IBD, aged 0–18 years (median age at diagnosis, 11.96 years) center Canada their family members (2305 total). Variants believed cause IBD were validated...
Abstract Growing evidence suggests receipt of live‐attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe needed due to lapses in herd immunity. A 2‐day consortium experts infectious diseases, transplantation, vaccinology, immunology was held with the objective review create expert recommendations for clinicians when considering live post‐SOT. For consideration VV MMR post‐transplant, exists only kidney liver recipients. vaccine post‐SOT, consider vaccination...
Abstract Background IgE‐mediated food allergy (FA) is a global health concern with substantial individual and societal implications. While diverse intervention strategies have been researched, inconsistencies in reported outcomes limit evaluations of FA treatments. To streamline promote consistent reporting, the Core Outcome Measures for Food Allergy (COMFA) initiative aimed to establish Set (COS) clinical trials observational studies interventions. Methods The project involved review...
Abstract Background Peanut and tree nut allergies are the most important causes of anaphylaxis. Co‐reactivity to more than one is frequent, co‐sensitization in absence clinical data often obtained. Confirmatory oral food challenges (OFCs) inconsistently performed. Objective To investigate utility basophil activation test (BAT) diagnosing peanut allergies. Methods The Markers Of Nut Allergy Study (MONAS) prospectively enrolled patients aged 0.5–17 years with confirmed and/or (almond, cashew,...
Abstract Vaccinationis a critical tool in the prevention of COVID‐19 infection for individuals and communities. The mRNA vaccines contain polyethylene glycol (PEG) as stabilizer. Currently, North America, only BNT162b2 (Pfizer‐BioNTech ) vaccine is approved aged 12–17. Most patients treated with contemporary regimens acute lymphoblastic leukemia receive PEG‐asparaginase (PEG‐ASNase) 10%–30% will develop allergic reactions. Optimizing access safety administration these critical. This report...
Although guidelines for fresh frozen plasma (FFP) use have been published, many transfusions are considered inappropriate. Current suggest few circumstances in which FFP transfusion to critically ill patients is warranted. The objectives of this study were evaluate the consistency Canadian administration and examine factors associated with inappropriate transfusions.Retrospective cohort study.15-bed medical surgical intensive care unit a teaching hospital.254 consecutive adults admitted...
International efforts have been focused on identifying children at low risk of clinically important traumatic brain injury in whom computed tomography (CT) neuroimaging can be avoided. We sought to determine if CT use for pediatric head trauma has decreased among US emergency departments (EDs).This was a cross-sectional analysis the National Hospital Ambulatory Care Medical Survey database nationally representative ED visits from 2007 2015. included <18 years age evaluated injury. weighting...
Forkhead box protein 3 (FOXP3) is the master transcription factor in CD4+CD25hiCD127lo regulatory T (Treg) cells. Mutations FOXP3 result IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome. Clinical presentation of syndrome broader than initially described, challenging understanding disease, its evolution, and treatment choice.We sought to study type extent immunologic abnormalities that remain ill-defined IPEX, across genetic clinical heterogeneity.We performed...
Previous proof-of-concept studies have shown that a short course of omalizumab can safely accelerate the oral immunotherapy schedule for multiple allergens simultaneously. Considering high cost medication, dose-related efficacy at decreasing duration up-dosing phase must be objectively quantified before cost-benefit analyses performed. The primary objective this trial will to compare 2 dosages placebo time-to-maintenance dose during symptom-driven multi-food OIT protocol.A total 90...