A5089530144- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Pain Management
- Probiotics and Fermented Foods
- Bacterial biofilms and quorum sensing
- Orthopedic Surgery and Rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Milk Quality and Mastitis in Dairy Cows
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Nerve Injury and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
- Organ Donation and Transplantation
- COVID-19 epidemiological studies
- Airway Management and Intubation Techniques
- Peripheral Nerve Disorders
- Cardiac Arrest and Resuscitation
- RNA Interference and Gene Delivery
- Vaccine Coverage and Hesitancy
McMaster University
2016-2024
Université de Sherbrooke
2022-2023
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2022
Population Health Research Institute
2020
Université de Montréal
2012-2017
<h3>Importance</h3> Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported. <h3>Objective</h3> To evaluate effect of<i>Lactobacillus rhamnosus</i>GG on preventing VAP, additional infections,...
Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these during critical illness due to underlying diseases clinical interventions, potentially influencing patient outcomes. We sought profile the composition of critically ill mechanically ventilated patients, determine whether diversity is associated with severity mortality. conducted a prospective, observational study patients high incidence pneumonia 2...
Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and overall infection in critically ill patients. However, these studies small, largely single-center, at risk bias. The aim PROSPECT pilot trial was to determine feasibility conducting a larger prevent VAP mechanically ventilated patients intensive care unit (ICU). In randomized blinded trial,...
Introduction Ventilator-associated pneumonia (VAP) is the most common healthcare-associated infection in critically ill patients. Prior studies suggest that probiotics may reduce VAP and other infections patients; however, previous randomised trials were small, single centre studies. The Probiotics: Prevention of Severe Pneumonia Endotracheal Colonization Trial (PROSPECT) aims to determine impact probiotic Lactobacillus rhamnosus GG on clinically important outcomes adults. Methods PROSPECT a...
Respiratory infections are a leading cause of morbidity and mortality worldwide. Bacterial pathogens often colonize the upper respiratory tract (nose or mouth) prior to causing lower invasive disease. Interactions within between colonizing bacteria resident microbiota could contribute colonization success subsequent transmission. Human carriage studies have identified associations such as Streptococcus pneumoniae members microbiota, although few mechanisms competition cooperation been would...
ABSTRACT The Streptococcus Milleri Group (SMG) comprising of intermedius, anginosus and constellatus are commensal bacteria commonly found in healthy individuals. These increasingly being recognized as opportunistic pathogens that can cause purulent infections at sterile body sites have also been identified the sputum individuals with cystic fibrosis. Although mechanisms conversion to not well understood, auto-aggregation is a key driver biofilm adhesion cohesion many Streptococci...
Worldwide, the number of patients waiting for organ transplantation exceeds organs available. Program uncontrolled donation after circulatory death (uDCD) implemented in Europe has resulted a 10-15% expansion donor pool. We aimed to describe eligible an uDCD program regional tertiary care center.We conducted retrospective cohort study Canadian academic center located rural area including all adults who received cardiopulmonary resuscitation 2016 and died emergency department (ED) or during...
( Can J Anesth/J Anesth. 2022;69:1017–1024)) While general anesthesia (GA) is not the preferred technique for cesarean delivery (CD), due to risk of gastric aspiration, it sometimes used emergent or in setting contraindications neuraxial anesthesia. Opioids are often nonobstetric populations during attenuate hemodynamic response laryngoscopy. In pregnant patients with hypertensive disorders pregnancy, opioids avoid exaggerated sympathetic responses intubation. However, beta-blockers,...
Neurologically deceased organ donors (NDDs) generally display an immune response involving intense production of pro-inflammatory cytokines referred to as the cytokine storm. The sudden surge inflammatory mediators in circulation promotes tissue and damages ultimately leads poor transplant outcome. As microRNAs (miRNAs) are frequently proposed key regulators inflammation relatively stable circulation, changes their profiles could play a role onset storm NDDs. In this proof-of-concept study,...