A5044360523- Immune Response and Inflammation
- Immune cells in cancer
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Immune responses and vaccinations
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Barrier Structure and Function Studies
- Osteoarthritis Treatment and Mechanisms
- Tryptophan and brain disorders
- Lipid Membrane Structure and Behavior
- Vector-borne infectious diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Enhanced Recovery After Surgery
- Rabies epidemiology and control
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Dietary Effects on Health
- Intensive Care Unit Cognitive Disorders
- Chemokine receptors and signaling
- interferon and immune responses
- Pneumocystis jirovecii pneumonia detection and treatment
GlaxoSmithKline (Canada)
2024-2025
McMaster University
2013-2023
McMaster University Medical Centre
2015-2023
Liverpool School of Tropical Medicine
2020-2023
Monocyte phenotype and output changes with age, but why this occurs how it impacts anti-bacterial immunity are not clear. We found that, in both humans mice, circulating monocyte function was altered age due to increasing levels of TNF the circulation that occur as part aging process. Ly6C+ monocytes from old (18-22 mo) mice CD14+CD16+ intermediate/inflammatory older adults also contributed "age-associated inflammation" they produced more inflammatory cytokines IL6 steady state when...
Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these during critical illness due to underlying diseases clinical interventions, potentially influencing patient outcomes. We sought profile the composition of critically ill mechanically ventilated patients, determine whether diversity is associated with severity mortality. conducted a prospective, observational study patients high incidence pneumonia 2...
Rationale: Localized autoimmune responses have been reported in patients with severe eosinophilic asthma, characterized by eosinophil degranulation and airway infections. Objective: To determine the presence of autoantibodies against macrophage scavenger receptors within airways their effects on function susceptibility to infection. Methods: Anti-EPX (eosinophil peroxidase), anti-MARCO (macrophage receptor collagenous structure) IgG titers, T1 T2 (type 1/2) cytokines were measured 221 sputa...
Rationale: Pneumococcal colonization is key to the pathogenesis of invasive disease but also immunogenic in young adults, protecting against recolonization. Colonization rarely detected older despite high rates pneumococcal disease.Objectives: To establish experimental human healthy adults aged 50-84 years, measure immune response challenge, and assess protective effect prior autologous strain rechallenge.Methods: Sixty-four participants were inoculated with Streptococcus pneumoniae...
Abstract Background The risk of herpes zoster (HZ) increases with age and in immunocompromised (IC) patients. Recombinant vaccine (RZV) is currently recommended Canada for people aged ≥ 50 years. objectives the current study were to evaluate cost-effectiveness public health impact RZV versus no HZ vaccination select Canadian IC adult populations. Methods ZOster ecoNomic Analysis ImmunoCompromised (ZONA IC) model followed a base-case cohort 1600 patients hematopoietic stem-cell transplant...
Inflammation contributes to obesity-related hyperinsulinemia and insulin resistance, which often precede type 2 diabetes. is one way that obesity can promote resistance. It not clear if the extent of obesity, hyperinsulinemia, or hyperglycemia, underpins changes in cellular immunity during diet-induced obesity. In particular, requirement for directionality relationship between resistance monocyte characteristics poorly defined. Inflammatory cytokines such as tumor necrosis factor (TNF)...
Abstract Aging is accompanied by changes in hematopoiesis and consequently leukocyte phenotype function. Although age-related bone marrow are fairly well documented, extramedullary less described. We observed that 18–22-mo-old mice had larger spleens than young controls found the enlargement was caused increased monopoiesis. Because often driven inflammation, we hypothesized chronic, low-level inflammation occurs with age a causal agent splenomegaly. To test this theory, compared number of...
We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in expression of DGKδ during differentiation 3T3-L1 cells to adipocytes, as well synthesis neutral polar lipids. When undifferentiated fibroblasts are transfected express DGKδ, there increased triglyceride without adipocytes. Hence, promotes Lipid decreased knockout mouse embryo fibroblasts, especially for lipids with shorter acyl chains limited unsaturation. This reduction...
The aim of this study was to update previously estimated public health impact and cost effectiveness recombinant zoster vaccine (RZV) for the prevention herpes (HZ) in Canadians aged ≥50 years using longer-term RZV efficacy waning data real-world coverage completion. A multicohort Markov model used conduct a cost-utility analysis comparing with no HZ vaccination among years. Real-world were first-dose (17.5%) second-dose completion (65%). Vaccine applied from up 8-year follow-up ZOE-50...
Abstract: Worldwide, infectious disease is responsible for much of the morbidity and mortality in elderly. As number individuals over age 65 increases, economic social costs treating these infections will become a major challenge. Vaccination most effective least costly preventative measure our arsenal; however, vaccines that are children young adults often ineffective older adults. This result deterioration immune function occurs with age, referred to as immunosenescence. Age-associated...
Type I IFN holds a critical role in host defence, providing protection against pathogenic organisms through coordinating pro-inflammatory response. provides additional mitigating this inflammatory response, preventing immunopathology. Within the context of viral infections, type signalling commonly results successful clearance. Conversely, during bacterial is less predictable, leading to either detrimental or beneficial outcomes. The factors responsible for variability remain unclear. Here,...
Abstract Rationale Pneumococcal colonisation is key to the pathogenesis of invasive disease, but also immunogenic in young adults, protecting against re-colonisation. Colonisation rarely detected older despite high rates pneumococcal disease. Objectives To establish experimental human healthy adults aged 50—84 years, measure immune response challenge, and assess protective effect prior autologous strain rechallenge. Methods Sixty-four participants were inoculated with Streptococcus...
Abstract Monocytes are a key cell type contributing to age-associated inflammation or inflammaging. Since monocytes have the potential enter circulation and differentiate into macrophages in tissues, they capable of having systemic effect on health. Here, we characterize aging transcriptional regulation monocyte subpopulations bone marrow. We find that classical (Ly6c high) non-classical low) exhibit distinct profiles. These were associated with changes epigenomic landscape driven by...
Abstract Streptococcus pneumoniae colonization in the upper respiratory tract is linked to pneumococcal disease development, predominantly affecting very young and older adults. As global population ages comorbidities increase, there a heightened concern about this infection. We investigated immunological responses of adults controlled human infection by analysing cellular composition gene expression nasal mucosa. Our comparative analysis with younger revealed distinct patterns individuals...