A5074380996- Sepsis Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Electrolyte and hormonal disorders
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renal function and acid-base balance
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- Parathyroid Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Airway Management and Intubation Techniques
- COVID-19 and Mental Health
- Infant Nutrition and Health
National Guard Health Affairs
2017-2024
King Abdulaziz Medical City
2015-2024
King Abdullah International Medical Research Center
2015-2024
King Saud bin Abdulaziz University for Health Sciences
2015-2024
Science Council
2024
Weatherford College
2021
Sulaiman Al Rajhi Colleges
2021
American University of Beirut
2021
University of Birmingham
2015
The appropriate caloric goal for critically ill adults is unclear. We evaluated the effect of restriction nonprotein calories (permissive underfeeding), as compared with standard enteral feeding, on 90-day mortality among adults, maintenance full recommended amount protein in both groups.At seven centers, we randomly assigned 894 a medical, surgical, or trauma admission category to permissive underfeeding (40 60% calculated requirements) feeding (70 100%) up 14 days while maintaining similar...
Since the identification of first case infection with Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia June 2012, number laboratory-confirmed cases has exceeded 941 globally, which 347 died. The disease presents as severe often shock, acute kidney injury, and coagulopathy. Recently, we observed three who presented neurologic symptoms. These are so far reported injury associated MERS-CoV infection.
We explored the feasibility of collecting convalescent plasma for passive immunotherapy Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using ELISA to screen serum samples from 443 potential donors: 196 patients with suspected or laboratory-confirmed MERS-CoV infection, 230 healthcare workers, and 17 household contacts exposed MERS-CoV. ELISA-reactive were further tested indirect fluorescent antibody microneutralization assays. Of samples, 12 (2.7%) had a reactive...
As of September 30, 2015, a total 1589 laboratory-confirmed cases infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use convalescent plasma (CP) has suggested as potential based on existing evidence from other viral infections. We aim study feasibility CP well its safety and clinical laboratory effects in critically ill patients MERS-CoV...
To describe patient characteristics, clinical manifestations, disease course including viral replication patterns, and outcomes of critically ill patients with severe acute respiratory infection from the Middle East syndrome to compare these features due other etiologies.Retrospective cohort study.Patients admitted ICUs in 14 Saudi Arabian hospitals.Critically laboratory-confirmed (n = 330) between September 2012 October 2015 were compared consecutive community-acquired non-Middle etiology...
The efficacy and safety of prone positioning is unclear in nonintubated patients with acute hypoxemia COVID-19.To evaluate the adverse events adult COVID-19.Pragmatic, unblinded randomized clinical trial conducted at 21 hospitals Canada, Kuwait, Saudi Arabia, US. Eligible COVID-19 were not intubated required oxygen (≥40%) or noninvasive ventilation. A total 400 enrolled between May 19, 2020, 18, 2021, final follow-up was completed July 2021.Patients to awake (n = 205) usual care without...
The optimal nutritional strategy for critically ill adults at high risk is unclear.To examine the effect of permissive underfeeding with full protein intake compared standard feeding on 90-day mortality in patients different baseline risk.This a post hoc analysis PermiT (Permissive Underfeeding versus Target Enteral Feeding Adult Critically Ill Patients) trial.Nutritional was categorized by modified Nutrition Risk score, defined as score 5-9 and low 0-4. Additional analyses were performed...
Background Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) acute hypoxemic failure, but effectiveness of this approach not studied. Methods Patients MERS from 14 Saudi Arabian centers were included analysis. who initially managed NIV compared to only invasive mechanical (invasive MV). Results Of 302 critically ill patients, was 105 (35%) whereas 197 (65%) MV. had lower baseline SOFA score and less extensive infiltrates on chest...
Importance Helmet noninvasive ventilation has been used in patients with COVID-19 the premise that helmet interface is more effective than mask delivering prolonged treatments high positive airway pressure, but data about its effectiveness are limited. Objective To evaluate whether compared usual respiratory support reduces mortality acute hypoxemic failure due to pneumonia. Design, Setting, and Participants This was a multicenter, pragmatic, randomized clinical trial conducted 8 sites Saudi...
Despite being the epicenter of recent pandemics, little is known about critical care in Asia. Our objective was to describe structure, organization, and delivery Asian ICUs.A web-based survey with following domains: hospital organizational characteristics, ICU staffing, procedures therapies available written protocols policies.ICUs from 20 countries April 2013 January 2014. Countries were divided into low-, middle-, high-income based on 2011 World Bank Classification.ICU directors or...
Antiplatelet therapy may attenuate the undesirable effects of platelets on inflammatory cascades in critical illness. The objective this study was to evaluate association between aspirin during intensive care unit (ICU) stay and all-cause mortality. This a nested cohort within two randomized controlled trials which all enrolled patients (N = 763) were grouped according intake ICU stay. primary endpoints mortality hospital Secondary included development severe sepsis stay, length duration...
Abstract Objective The aim of this study is to examine the association hypophosphatemia and hyperphosphatemia on first day ICU admission with mortality in septic critically ill patients. Methods In retrospective cohort study, all adult patients who were admitted medical-surgical ICUs between 2014 2017 sepsis or shock categorized as having hypophosphatemia, normophosphatemia based 1 serum phosphate values. We compared clinical characteristics outcomes three groups. used multivariate analysis...
The aim of this study was to check if serum lactate independently associated with mortality among critically ill patients.This a single-center, retrospective cohort study. All adult patients (>18 years age) who had at least 1 measurement within 24 hours admission intensive care unit (ICU) between January 2002 and December 2017 were included in the analysis. Patients stratified into 3 groups: those <2 mmol/L (normal level), 2 4 (intermediate >4 (high level). primary outcome in-hospital...
The optimal amount and timing of protein intake in critically ill patients are unknown. REPLENISH (Replacing Protein via Enteral Nutrition a Stepwise Approach Critically Ill Patients) trial evaluates whether supplemental enteral added to standard nutrition achieve high given from ICU day five until discharge or 90 as compared no moderate would reduce all-cause 90-day mortality adult mechanically ventilated patients.
The association of troponin-I levels and outcome in medical-surgical ICU patients has been studied before populations with low to moderate prevalence cardiovascular risk factors. objective this article is examine the hospital mortality high factors who were admitted indications a non-cardiac intensive care unit.This was retrospective study adult tertiary between July 2001 November 2011. Data extracted from prospectively collected clinical laboratory databases. Patients stratified based on...
The objective of this study was to evaluate leptin, ghrelin, and leptin/ghrelin ratio in critically ill patients association with outcomes. This is a sub-study the PermiT trial (ISRCTN68144998). A subset 72 who were expected stay >14 days Intensive care unit enrolled. Blood samples collected on 1, 3, 5, 7, 14. Samples analyzed for leptin active ghrelin addition other hormones. Baseline calculated, stratified into low high based median value 236. There considerable variation baseline level:...
Venous thromboembolism (VTE) remains a common problem in critically ill patients. Pharmacologic prophylaxis is currently the standard of care based on high-level evidence from randomized controlled trials. However, limited exists regarding effectiveness intermittent pneumatic compression (IPC) devices. The Pneumatic compREssion for preventing VENous Thromboembolism (PREVENT trial) aims to determine whether adjunct use IPC with pharmacologic compared alone patients reduces risk VTE. PREVENT...
This study aims to examine the outcome of end-stage renal disease (ESRD) patients admitted with sepsis intensive care unit (ICU).Single centre, retrospective cohort study.The was conducted in Intensive Care Department King Abdulaziz Medical City, Riyadh, Saudi Arabia.Data were extracted from a prospectively collected ICU database 2002 2017. Patients considered have based on sepsis-3 definition and stratified into 2 groups presence or absence ESRD.The primary in-hospital mortality. Secondary...
Abstract Background Protein intake is recommended in critically ill patients to mitigate the negative effects of critical illness-induced catabolism and muscle wasting. However, optimal dose enteral protein remains unknown. We hypothesize that supplemental (1.2 g/kg/day) added standard nutrition formula achieve high amount (range 2–2.4 given from ICU day 5 until discharge or 90 as compared no moderate (0.8–1.2 would reduce all-cause 90-day mortality adult mechanically ventilated patients....
Nutritional support is an essential part of the management critically ill patients. However, optimal caloric intake has not been systematically evaluated. We aim to compare two strategies enteral feeding: permissive underfeeding versus target feeding. This international multi-center randomized controlled trial in medical- surgical adult Using a centralized allocation, 862 patients will be or Patients group receive 50% (acceptable range 40% 60%) calculated requirement, while those targeted...
Maintaining the cuff pressure of endotracheal tubes (ETTs) within 20–30 cmH2O is a standard practice. The aim study was to evaluate effectiveness practice in maintaining target range. This prospective observational conducted tertiary-care intensive care unit, which respiratory therapists (RTs) measured 6 hourly by handheld manometer. In this study, research RT checked 2–4 h after clinical measurement. Percentages patients with levels above and below range were calculated. We identified...
Clinical handover is an important process for the transition of patient-care responsibility to next healthcare provider, but it may divert attention team away from active patients. This challenging in Emergency Department (ED) because highly dynamic patient conditions and likely relevant that requires time-sensitive therapies, such as sepsis. We aimed examine management outcomes patients presenting with sepsis septic shock ED during nursing handover.This retrospective cohort study was...