A5017442221- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Vitamin C and Antioxidants Research
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Infectious Encephalopathies and Encephalitis
- Drug-Induced Hepatotoxicity and Protection
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Arrest and Resuscitation
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- Hemodynamic Monitoring and Therapy
- Online and Blended Learning
- Parathyroid Disorders and Treatments
- Trace Elements in Health
- Electrolyte and hormonal disorders
- Climate Change and Health Impacts
- Atrial Fibrillation Management and Outcomes
- Hepatitis C virus research
- Vitamin K Research Studies
- Platelet Disorders and Treatments
King Saud bin Abdulaziz University for Health Sciences
2013-2024
King Abdullah International Medical Research Center
2018-2024
National Guard Health Affairs
2019-2024
King Abdulaziz Medical City
2013-2024
King Saud Medical City
2023
Oklahoma State University Center for Health Sciences
2021
North Dakota State University
2006
It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has investigated in randomized clinical trials. Results from vitro and animal studies suggest that a combination lopinavir/ritonavir interferon-β1b (IFN-β1b) may be effective against MERS-CoV. The aim this study is to investigate efficacy with recombinant IFN-β1b provided standard supportive care, compared placebo care patients...
The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy a combination therapy lopinavir/ritonavir recombinant interferon-β1b provided standard supportive care, compared to placebo in hospitalized patients laboratory-confirmed MERS. is designed as recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. aim this article describe statistical analysis plan for...
BackgroundWhether combined treatment with recombinant interferon beta-1b and lopinavir–ritonavir reduces mortality among patients hospitalized Middle East respiratory syndrome (MERS) is unclear.MethodsWe conducted a randomized, adaptive, double-blind, placebo-controlled trial that enrolled at nine sites in Saudi Arabia. Hospitalized adults laboratory-confirmed MERS were randomly assigned to receive plus (intervention) or placebo for 14 days. The primary outcome was 90-day all-cause...
Abstract Background Type I interferons (IFNs) are essential antiviral cytokines induced upon respiratory exposure to coronaviruses. Defects in type IFN signaling can result severe disease viral infection and associated with worse clinical outcomes. Neutralizing autoantibodies (auto‐Abs) IFNs were reported as a risk factor for life‐threatening COVID‐19, but their presence has not been evaluated patients Middle East syndrome (MERS). Methods We the prevalence of auto‐Abs cohort hospitalized...
Ascorbic acid represents an appealing option for clinicians to utilize in the context of global COVID-19 pandemic due its proposed clinical efficacy, relative safety, and low cost. The aim this study was evaluate efficacy safety using ascorbic supplemental doses as adjunctive therapy patients critically ill with COVID-19. This a two-center, non-interventional, retrospective cohort study. All adult admitted ICU confirmed diagnosis between March 1st December 31st, 2020, were included final...
Abstract Background Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against use of this treatment. To date, effect iNO on clinical outcomes critically ill moderate-to-severe ARDS remains arguable. Therefore, study aimed evaluate ARDS. Methods This multicenter, retrospective cohort included adult confirmed treated from March 01, 2020, until July 31, 2021....
Abstract Objective The aim of this study is to examine the association hypophosphatemia and hyperphosphatemia on first day ICU admission with mortality in septic critically ill patients. Methods In retrospective cohort study, all adult patients who were admitted medical-surgical ICUs between 2014 2017 sepsis or shock categorized as having hypophosphatemia, normophosphatemia based 1 serum phosphate values. We compared clinical characteristics outcomes three groups. used multivariate analysis...
Abstract Background Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves immune system function and has shown to reduce risk several diseases. The role in critically ill septic patient been addressed multiple studies; however, it’s COVID-19 patients still unclear. aim this study was evaluate use as an adjunctive therapy on mortality patients. Methods This two-center, non-interventional, retrospective cohort admitted intensive...
Zinc is a trace element that plays role in stimulating innate and acquired immunity. The of zinc critically ill patients with COVID-19 remains unclear. This study aims to evaluate the efficacy safety sulfate as adjunctive therapy COVID-19.Patients aged ≥ 18 years who were admitted intensive care unit (ICU) two tertiary hospitals Saudi Arabia retrospectively assessed for use from March 1, 2020 until 31, 2021. After propensity score matching (1:1 ratio) based on selected criteria, we...
Antibiotic resistance is a critical global health concern, driven by biofilm formation and the declining effectiveness of conventional therapies. This study investigates polymer-lipid hybrid nanoparticles (PLNs) as an innovative drug delivery system to enhance antibacterial efficacy gentamicin (Gen) while addressing challenges related its hydrophilicity encapsulation. Using optimized double-emulsification/solvent-evaporation technique, PLNs were designed improve entrapment efficiency (EE%)...
Herbal medicine has been widely utilized by pregnant women despite the limited available evidence regarding safety and efficacy of that practice. The current studies, from different countries, estimated use herbal during pregnancy range 7% up to 96%. aim this study is determine prevalence, attitude, source information, reasoning behind among in Saudia Arabia.
Atrial fibrillation (Afib) can contribute to a significant increase in mortality and morbidity critically ill patients. Thus, our study aims investigate the incidence clinical outcomes associated with new-onset Afib patients COVID-19. A multicenter, retrospective cohort includes adult COVID-19 admitted intensive care units (ICUs) from March, 2020 July, 2021. Patients were categorized into two groups (new-onset vs control). The primary outcome was in-hospital mortality. Other secondary, such...
Abstract Background Dexamethasone usually recommended for patients with severe coronavirus disease 2019 (COVID-19) to reduce short-term mortality. However, it is uncertain if another corticosteroid, such as methylprednisolone, may be utilized obtain better clinical outcome. This study assessed dexamethasone’s and safety outcomes compared methylprednisolone. Methods A multicenter, retrospective cohort was conducted between March 01, 2020, July 31, 2021. It included adult COVID-19 who were...
Purpose Coagulation abnormalities are one of the most important complications severe COVID-19, which might lead to venous thromboembolism (VTE). Hypercoagulability with hyperfibrinogenemia causes large vessel thrombosis and major thromboembolic sequelae. Statins potentially a potent adjuvant therapy in COVID-19 infection due their pleiotropic effect. This study aims evaluate effectiveness statins reducing risk among hospitalized critically ill patients COVID-19. Methods A multicenter,...
Despite the worldwide recognition of importance quality life (QOL) assessment, research data on QOL for renal and liver transplant recipients are limited. The main objective this study was to explore compare in patients.This cross-sectional conducted at King Abdulaziz Medical City, Saudi Arabia.Saudis 16 years age or more who received transplantation least three months before participated. evaluated using World Health Organization instrument (WHOQOL-BREF).Renal patients were highly...
Tocilizumab is an IgG1 class recombinant humanized monoclonal antibody that directly inhibits the IL-6 receptor. Several randomized clinical trials have evaluated its safety and efficacy in patients with coronavirus disease 2019 (COVID-19), these studies demonstrate conflicting results. Our study aimed to determine association between tocilizumab treatment microbial isolation emergence of multidrug-resistant bacteria critically ill COVID-19.A multicenter retrospective cohort was conducted at...
Aspirin is widely used as a cardioprotective agent due to its antiplatelet and anti-inflammatory properties. The literature has assessed evaluated role in hospitalized COVID-19 patients. However, no data are available regarding critically ill This study aimed evaluate the use of low-dose aspirin (81-100 mg) impact on outcomes patients with COVID-19.A multicenter, retrospective cohort all adult confirmed admitted intensive care units (ICUs) between March 1, 2020, 31, 2021. Eligible were...
Background The cardiovascular complications of Coronavirus Disease 2019 (COVID-19) may be attributed to the hyperinflammatory state leading increased mortality in patients with COVID-19. HMG-CoA Reductase Inhibitors (statins) are known have pleiotropic and anti-inflammatory effects antiviral activity along their cholesterol-lowering activity. Thus, statin therapy is potentially a potent adjuvant COVID-19 infection. This study investigated impact use on clinical outcome critically ill Methods...
Abstract Background: Zinc is a trace element that plays role in stimulating innate and acquired immunity. The of zinc critically ill patients with COVID-19 remains unclear. This study aims to evaluate the efficacy safety sulfate as adjunctive therapy COVID-19. Methods: Patients aged ≥ 18 years who were admitted intensive care unit (ICU) two tertiary hospitals Saudi Arabia retrospectively assessed for use, from 01 March 2020 until 31-December 2020. We association use in-hospital 30-day...
Hyperuricemia has been linked to various adverse clinical outcomes. Data on the outcomes and relationship between hyperuricemia sepsis remain limited. The aim of this study was evaluate impact in patients identify whether it can predict mortality patient population.