A5071602908- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Renin-Angiotensin System Studies
- Advanced Nanomaterials in Catalysis
- Chronic Myeloid Leukemia Treatments
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Receptor Mechanisms and Signaling
- Luminescence and Fluorescent Materials
- Hormonal Regulation and Hypertension
- Natural Antidiabetic Agents Studies
- Analytical chemistry methods development
- Computational Drug Discovery Methods
- Quinazolinone synthesis and applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Treatments and Mutations
- Electrochemical Analysis and Applications
- Melanoma and MAPK Pathways
- Chemotherapy-induced organ toxicity mitigation
- Emergency and Acute Care Studies
- Bioactive Compounds and Antitumor Agents
King Saud University
2018-2025
Jouf University
2024-2025
Sion College
2025
King Saud bin Abdulaziz University for Health Sciences
2021-2024
King Abdullah International Medical Research Center
2023-2024
Northern Border University
2024
King Abdulaziz Medical City
2023
National Guard Health Affairs
2023
Nova Southeastern University
2014-2020
South University
2019-2020
Selective fluorometric protocol for the quantification of vancomycin.
Cisplatin (CIS) and etoposide (ETP) combination therapy is highly effective for treating various cancers. However, the potential pharmacokinetic interactions between these drugs necessitates selective sensing methods to quantitate both CIS ETP levels in patient's plasma. This work develops a dual fluorescence probe strategy using glutathione-capped copper nanoclusters (GSH-CuNCs) nitrogen-doped carbon dots (N-CDs) simultaneous analysis of ETP. The signal GSH-CuNCs at 615 nm increased...
The proliferative effects of angiotensin (Ang) II in vascular smooth muscle cells (VSMCs) through its ability to stimulate extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway have been established. main goal this study was explore whether Ang III induces ERK1/2 MAPK VSMC proliferation cultured Wistar VSMCs. Further, the actions were compared those observed VSMCs derived from spontaneously hypertensive rat (SHR). We hypothesized that will similar as induce cellular may be...
This research work introduces a novel sensor that utilizes two fluorophores to enable simultaneous monitoring of gentamicin sulphate (GNT) and ketorolac tromethamine (KET). The innovative is composed carbon dots (CDs) derived from black grapes (BG) eosin Y (EY) dye. interaction between the studied drugs EY/BG@CDs components allows for their detection where GNT quenches fluorescence EY at 535 nm without affecting CDs, while KET BG@CDs 385 impacting fluorescence. probe was successfully...
As a consequence of chronic hyperglycemia, diabetes complications and tissue damage are exacerbated. There is evidence that natural phytochemicals, including resveratrol, bioactive polyphenol, may be able to reduce oxidative stress improve insulin sensitivity. However, resveratrol's limited bioavailability hampers its therapeutic effectiveness. By using liposomes, resveratrol better delivered into the body more bioavailable. The objective this study was assess cardioprotective potential...
Abemaciclib (AC) is a novel, orally available drug molecule approved for the treatment of breast cancer. Due to its low bioavailability, administration frequency two three times day that can decrease patient compliance. Sustained release formulation are needed prolong action and reduce adverse effects. The aim current study was develop sustained NSs AC. Nanosponges (NSs) prepared by emulsion-solvent diffusion method using ethyl-cellulose (EC) Kolliphor P-188 (KP-188) as sustained-release...
Diabetic nephropathy (DN) is among the most common microvascular complications of diabetes resulting in end-stage renal disease and therefore search for candidates which can ameliorate kidney function needed simultaneously with standard diabetic pharmacotherapy. The current study was aimed to investigate effect long term sacubitril/valsartan therapy (LCZ696) rats assess its ameliorative impact against various pathological parameters such as oxidative stress, inflammation glomerulosclerosis...