Sally I. Eissa

ORCID: 0000-0001-5368-9786
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About
Contact & Profiles
Research Areas
  • Synthesis and biological activity
  • Quinazolinone synthesis and applications
  • Synthesis and Biological Evaluation
  • Multicomponent Synthesis of Heterocycles
  • Cancer therapeutics and mechanisms
  • Multiple Myeloma Research and Treatments
  • Bioactive Compounds and Antitumor Agents
  • Protein Degradation and Inhibitors
  • HER2/EGFR in Cancer Research
  • Synthesis and Characterization of Heterocyclic Compounds
  • Histone Deacetylase Inhibitors Research
  • interferon and immune responses
  • Cytokine Signaling Pathways and Interactions
  • Computational Drug Discovery Methods
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Beetle Biology and Toxicology Studies
  • Synthesis and Biological Activity
  • Angiogenesis and VEGF in Cancer

Al-Azhar University
2014-2023

Alfaisal University
2020-2022

Almaarefa University
2020-2022

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed synthesised. IC

10.1080/14756366.2021.2017911 article EN cc-by Journal of Enzyme Inhibition and Medicinal Chemistry 2022-01-10

Eleven novel benzoxazole/benzothiazole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The compounds evaluated for their cytotoxic activities against HepG-2, HCT-116, PC3, MCF-7 cells. Generally, the open with semicarbazide thiosemicarbazide moieties (10, 13a-c, 14, 17a,b) exhibited higher than derivatives closed glutarimide moiety (8a-d). In particular, compound 13a (IC50 = 6.14, 5.79, 10.26, 4.71 µM MCF-7, respectively) 14...

10.1002/ardp.202300097 article EN Archiv der Pharmazie 2023-06-28

In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The compounds evaluated for their cytotoxic activities against HepG-2, HCT-116, PC3 MCF-7 cell lines. Generally, opened of glutarimide ring exhibited higher than closed ones. Compounds 21a-b 11d,g showed strong potencies all tested lines with IC50 values ranging from 8.27 25.20 µM comparable that (IC50 32.12 76.91 µM). most active further in...

10.1080/07391102.2023.2187217 article EN Journal of Biomolecular Structure and Dynamics 2023-03-08

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, series novel 6-methoxy naphthalene derivatives was efficiently synthesized characterized by spectral elemental analyses. The newly compounds were evaluated for their activities using carrageenin-induced rat paw edema model, acetic acid induced writhing model mice anti-pyretic activity yeast hyperpyrexia method as well ulcerogenic effects. Among the compounds, thiourea derivative (<b>6a, e</b>)...

10.1055/s-0033-1363251 article EN Drug Research 2014-01-20
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