A5086607223- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Synthesis and Biological Activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Beetle Biology and Toxicology Studies
- Angiogenesis and VEGF in Cancer
Al-Azhar University
2014-2023
Alfaisal University
2020-2022
Almaarefa University
2020-2022
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed synthesised. IC
Novel benzamide derivatives as anti adenovirus, HSV-1, coxsackievirus, and SARS-CoV-2: in vitro silico study.
Eleven novel benzoxazole/benzothiazole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The compounds evaluated for their cytotoxic activities against HepG-2, HCT-116, PC3, MCF-7 cells. Generally, the open with semicarbazide thiosemicarbazide moieties (10, 13a-c, 14, 17a,b) exhibited higher than derivatives closed glutarimide moiety (8a-d). In particular, compound 13a (IC50 = 6.14, 5.79, 10.26, 4.71 µM MCF-7, respectively) 14...
In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The compounds evaluated for their cytotoxic activities against HepG-2, HCT-116, PC3 MCF-7 cell lines. Generally, opened of glutarimide ring exhibited higher than closed ones. Compounds 21a-b 11d,g showed strong potencies all tested lines with IC50 values ranging from 8.27 25.20 µM comparable that (IC50 32.12 76.91 µM). most active further in...
As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, series novel 6-methoxy naphthalene derivatives was efficiently synthesized characterized by spectral elemental analyses. The newly compounds were evaluated for their activities using carrageenin-induced rat paw edema model, acetic acid induced writhing model mice anti-pyretic activity yeast hyperpyrexia method as well ulcerogenic effects. Among the compounds, thiourea derivative (<b>6a, e</b>)...