A5044436644- Geotechnical and Geomechanical Engineering
- Granular flow and fluidized beds
- Geotechnical Engineering and Soil Mechanics
- Landslides and related hazards
- Synthesis and characterization of novel inorganic/organometallic compounds
- Geotechnical Engineering and Underground Structures
- Chronic Lymphocytic Leukemia Research
- Coordination Chemistry and Organometallics
- Organometallic Complex Synthesis and Catalysis
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Inorganic and Organometallic Chemistry
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Medical Malpractice and Liability Issues
- COVID-19 Clinical Research Studies
- Economic and Financial Impacts of Cancer
- Bone health and treatments
- Rock Mechanics and Modeling
- Immunodeficiency and Autoimmune Disorders
- Chronic Kidney Disease and Diabetes
- Cytokine Signaling Pathways and Interactions
- Ferrocene Chemistry and Applications
- COVID-19 Impact on Reproduction
- International Human Rights and Reproductive Law
Abbott Northwestern Hospital
2024
St. Paul's Hospital
2021-2022
Cleveland Clinic Lerner College of Medicine
2021
Case Western Reserve University
2021
Cleveland Clinic
2021
University of Arizona
2021
University of Manchester
2005-2020
RTI Health Solutions
2013-2020
University of Warwick
2020
Coventry (United Kingdom)
2020
Two methods are described for the synthesis of unusual bivalent Group 4B metal alkyls M[CH(SiMe3)2]2(M = Ge, Sn,or Pb)from Li[CH(SiMe3)2] indiethyl ether at 0 to –20°C and (a) metal(II) chloride (M Sn or Pb) (b) M[N(SiMe3)2]2(M Ge Sn). At ambient temperature in cyclohexane benzene solutions yellow (Ge), red (Sn), purple (Pb), compounds monomeric a singlet electronic ground state. There colour changes between solid melt, tend become colourless –196 °C. The crystal structure tin(II) alkyl...
The reactions of SnCl2, PbCl2, or GeCl2, dioxan with LiNR12, OEt2 LiNR1R2, in Et2O at 0° yield the stable, monomeric, diamagnetic, coloured, volatile, hydrocarbon-soluble title compounds which are highly reactive.
Reaction of 2LiR [R =(Me3Si)2CH] and M[N(SiMe3)2]2 affords a new route to SnR2 also the isolation yellow, crystalline, volatile, diamagnetic GeR2; X-ray single crystal analysis former shows dimeric centrosymmetric structures with l(Sn-Sn)= 2·76 Å, ∠Sn–Sn–C (mean)= 115°, ∠C–Sn–C = 112°.
Abstract The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies suggested that the antibody content could influence patient outcomes. We conducted an open-label, trial adults with COVID-19 receiving oxygen within 12 d respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml or standard care. composite primary outcome was intubation death by 30...
A series of subvalent Group 4B metal amides general formula M(NR1R2)2[(i) R1= SiMe3, R2= But; M = Ge, Sn, or Pb; (ii) SiMe3; and (iii) GeMe3, SiEt3, GePh3; Ge Sn] has been prepared from the appropriate lithium amide metal(II) halide. Under ambient conditions, are pale yellow to red, thermochromic, diamagnetic, low-melting solids liquids, soluble in hydrocarbons (C6H6 C6H12) which they diamagnetic monomers. The lower homologues give parent molecular ions as highest m/e species. Infrared...
It is unclear how frequently unprovoked venous thromboembolism (VTE) reflects the presence of an occult cancer.The California Cancer Registry was used to identify diagnosed cases 19 common malignancies during a 6-year period. Cases were linked hospital discharge database incident VTE events in year before cancer diagnosis date. The standardized incidence ratio (SIR) determined by using age-, race-, and sex-specific rates California.Among 528,693 cases, 596 (0.11%) associated with within 1...
ABSTRACT The Osteosarcoma Surveillance Study was initiated in the United States 2003 to monitor for a potential association between osteoporosis treatment teriparatide and osteosarcoma. occurs at background incidence rate of approximately 2.5 cases per million year US adults aged 40 years or older. For this study, incident osteosarcoma diagnosed January 1, 2003, December 31, 2016, were identified through participating cancer registries States. Information on prior exposure medications...
This paper presents a numerical study on deep penetration mechanisms in granular materials with the focus effect of soil–penetrometer interface friction. A two-dimensional discrete element method has been used to carry out simulation tests ground that is under an amplified gravity K0 lateral stress boundary. The results show makes soil near penetrometer move complex displacement path, undergo evident loading and unloading process, rotation principal stresses as large 180°. In addition, leads...
A discrete element modelling of bonded granulates and investigation on the bond effect their behaviour are very important to geomechanics. This paper presents a two-dimensional (2-D) theory for with rolling resistance provides numerical into yielding granulates. The model consists mechanical contact models equations governing motion particles. key point is that assumption in original previously proposed by authors (55th CSCE-ASCE Conference, Hamilton, Ont., Canada, 2002; 313–320; J. Eng....
Signals emanating from the bone marrow microenvironment, such as stromal cells, are thought to support survival and proliferation of malignant cells in patients with myeloproliferative neoplasms (MPN). To examine this hypothesis, we established a coculture platform [cells cocultured directly (cell-on-cell) or indirectly (separated by micropore membrane)] designed interrogate interplay between Janus activated kinase 2-V617F (JAK2(V617F))-positive cells. Treatment atiprimod, potent JAK2...
Microsurgical epididymal sperm aspiration was a great advance in the therapy of patients with non-reconstructable, obstructive azoospermia, most notably congenital bilateral absence vas deferens. Using conventional in-vitro fertilization, pregnancies were rarely achieved because rate oocyte fertilization extremely poor. However, use retrieved spermatozoa conjunction intracytoplasmic injection (ICSI) has dramatically increased likelihood embryo formation. Typically, and harvesting are...
Hematocrit (H) levels can change during hemodialysis, and these changes in H are inversely related to blood volume (BV). The objectives of this study were determine whether mean arterial pressure (MAP) decreases with decreasing BV rising the relationship between dialysis induced intravascular depletion intradialytic morbid events (IME), defined as hypotension, cramping, or lightheadedness that led staff intervention. We monitored continuously using a noninvasive optical technique 93...
The Forteo Patient Registry (FPR) aims to estimate the incidence of osteosarcoma in US patients treated with teriparatide. Enrollment began 2009 and will continue through 2019, linkage planned 2024. To date, no incident cases have been identified among registered FPR. was established objective this paper is describe study methods, challenges encountered, progress date. FPR a prospective registry designed link data from participants annually state cancer registries. enrollment for 10 years...
BackgroundRilonacept inhibits the interleukin-1 pathway, and extended treatment in patients with recurrent pericarditis reduced recurrence risk by 98% Phase 3 trial RHAPSODY long-term extension (LTE). SARS-CoV-2 vaccination/infection may trigger recurrence, clinical practice, it is unknown whether to continue rilonacept during infection. This post-hoc analysis of LTE aimed inform management vaccinated against or who contract COVID-19.MethodsAnalysis was conducted from May 2020 June 2022. The...
The reaction of MCl2(M = Ge or Sn) Si2Cl6 with R1Li (R22N)Li [R1=(Me3Si)2CH, R2= Me3Si] and subsequent irradiation affords the stable metal-centred radicals R13Si·, R13M·, (R22N)3M·(e.g. R13Ge· has t½ > 4 months in C6H6 at 20 °C), solution e.s.r. spectra which show well defined hyperfine splittings [e.g. for (R22N)3Ge·, a decet septets, due to coupling 73Ge (I= 9/2) 14N 1)].
He(I) photoelectron (p.e.) spectraof (i) themonomeric, presumed-bent, compounds MR2, M(NR′2)2, and M(NR′R″)2[M = Ge, Sn, or Pb; R CH(SiMe3)2, R′= SiMe3, R″= CMe3], (ii) the linear HgR2 M′(NR′2)2(M Zn Hg), (iii) bent momomeric SnCl2 SnBr2 have been recorded, as well reference RH, R′2NH, R′R″NH. For Group 4 metal(II) alkyls first vertical ionisation potential (i.p.) is close to that of free metal; metal lone-pair orbital progressively higher in M(NR′R″), which it second band, being preceded by...
In this paper we present results of numerical simulations for the evaluation kinematic models non-coaxial granular materials by distinct element method (DEM). Strain-rate controlled monotonic and cyclic un-drained simple shear tests were specifically designed criteria established purpose. The examined are double-shearing model, double-sliding free-rotating double slip rotation rate model (DSR2 model) proposed authors (see accompanying paper). It is shown that assumption used in appears to...
To assess the impact of HAART use on AIDS-defining Kaposi's sarcoma and non-Hodgkin lymphoma (NHL) among adults with AIDS.Registry linkage study.Adults diagnosed AIDS from 1990 to 2000 in San Francisco case registry were matched cancer cases 1985 2002 California Cancer Registry. Multivariate Cox proportional hazard models used evaluate risk survival AIDS-related sarcoma, systemic NHL, primary central nervous system (CNS) lymphoma.Of 14 183 AIDS, 3028 776 254 CNS NHL. After adjustment for...
The purpose of this paper is to present a physically based plasticity model for non-coaxial granular materials. model, which we shall call the double slip and rotation rate (DSR2 model), pair kinematic equations governing velocity field. on discrete micro-analysis kinematics particles in contact, formulated by introducing quantity called averaged micro-pure (APR) into unified was proposed one authors. Our macro–micro mechanical analysis shows that APR non-linear function of, among other...