Michael Arad
A5020537575- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Adipose Tissue and Metabolism
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Pericarditis and Cardiac Tamponade
- Muscle Physiology and Disorders
- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Metabolism, Diabetes, and Cancer
- Eicosanoids and Hypertension Pharmacology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pancreatic function and diabetes
- Cardiovascular Issues in Pregnancy
- Mitochondrial Function and Pathology
- Renal Transplantation Outcomes and Treatments
- Infective Endocarditis Diagnosis and Management
- Pluripotent Stem Cells Research
- Peptidase Inhibition and Analysis
Sheba Medical Center
2016-2025
Tel Aviv University
2016-2025
Sequoia (United States)
2024
SEQUOIA (Italy)
2024
Harvard University
2002-2024
Brigham and Women's Hospital
2003-2024
Lahey Medical Center
2024
Baim Institute for Clinical Research
2024
Oregon Health & Science University
2024
Lahey Hospital and Medical Center
2024
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Abstract Cardiac amyloidosis is a serious and progressive infiltrative disease that caused by the deposition of amyloid fibrils at cardiac level. It can be due to rare genetic variants in hereditary forms or as consequence acquired conditions. Thanks advances imaging techniques possibility achieving non-invasive diagnosis, we now know more frequent than traditionally considered. In this position paper Working Group on Myocardial Pericardial Disease proposes an invasive definition...
Unexplained left ventricular hypertrophy often prompts the diagnosis of hypertrophic cardiomyopathy, a sarcomere-protein gene disorder. Because mutations in for AMP-activated protein kinase gamma2 (PRKAG2) cause an accumulation cardiac glycogen and that mimics we hypothesized cardiomyopathy might also be clinically misdiagnosed patients with other genes regulating metabolism.Genetic analyses performed 75 consecutive unrelated detected 40 mutations. In remaining 35 patients, PRKAG2,...
Advances in molecular genetics present new opportunities and challenges for cardiologists who manage patients families with cardiomyopathies. The aims of this position statement the European Society Cardiology Working Group on Myocardial Pericardial Diseases are to review general issues related genetic counselling, family screening testing a cardiomyopathy, provide key messages suggestions clinicians involved their management.
Mutations in PRKAG2, the gene for γ2 regulatory subunit of AMP-activated protein kinase, cause cardiac hypertrophy and electrophysiologic abnormalities, particularly preexcitation (Wolff-Parkinson-White syndrome) atrioventricular conduction block. To understand mechanisms by which PRKAG2 defects disease, we defined novel mutations, characterized associated histopathology, studied consequences introducing these mutations into yeast homologue Snf4. Although pathology caused Arg302Gln,...
Mutations in PRKAG2, the gene for γ2 regulatory subunit of AMP-activated protein kinase, cause cardiac hypertrophy and electrophysiologic abnormalities, particularly preexcitation (Wolff-Parkinson-White syndrome) atrioventricular conduction block. To understand mechanisms by which PRKAG2 defects disease, we defined novel mutations, characterized associated histopathology, studied consequences introducing these mutations into yeast homologue Snf4. Although pathology caused Arg302Gln,...
Systemic immune-mediated diseases (SIDs) include autoimmune and autoinflammatory (AD) affecting at least two-organ systems.1 Autoinflammatory refer to a growing family of conditions characterised by episodes unprovoked inflammation in the absence high autoantibody titres or auto reactive T lymphocytes, reflecting primary innate immune system dysfunction.1 Conversely, are aberrant B, dendritic cell responses, leading break tolerance against self-antigens, with predominantly cell-mediated...
Abstract Background Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but there no specific therapy diabetic disease. Sodium glucose transporter inhibitors (SGLT2I) are recently developed drugs that primarily work on the kidney. Clinical data describing cardiovascular benefits of SGLT2Is highlight potential therapeutic benefit these in prevention events and failure. However, underlying mechanism protection remains unclear. We investigated effect...
BackgroundOne of the major determinants exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. Aficamten oral selective cardiac myosin inhibitor that reduces gradients by mitigating hypercontractility.MethodsIn this phase 3, double-blind trial, we randomly assigned adults symptomatic HCM to receive aficamten (starting dose, 5 mg; maximum 20 mg)...
Background Rilonacept, a once‐weekly interleukin‐1 alpha and beta cytokine trap, reduced pericarditis recurrence in the phase 3 study, RHAPSODY (Rilonacept Inhibition of Interleukin‐1 Alpha Beta for Recurrent Pericarditis: A Pivotal Symptomatology Outcomes Study). The long‐term extension further explored recurrent natural history treatment duration decision‐making during 24 additional months open‐label rilonacept treatment. Methods Results Seventy‐four patients commenced extension, with...
Mutations in the gamma2 subunit (PRKAG2) of AMP-activated protein kinase produce an unusual human cardiomyopathy characterized by ventricular hypertrophy and electrophysiological abnormalities: Wolff-Parkinson-White syndrome (WPW) progressive degenerative conduction system disease. Pathological examinations affected hearts reveal vacuoles containing amylopectin, a glycogen-related substance.To elucidate mechanism which PRKAG2 mutations with abnormalities, we constructed transgenic mice...
Background— Nonobstructive hypertrophy localized to the cardiac apex is an uncommon morphological variant of hypertrophic cardiomyopathy (HCM) that often further distinguished by distinct giant negative T waves and a benign clinical course. The genetic relationship between HCM with typical morphology versus isolated apical incompletely understood. Methods Results— Genetic cause was investigated in 15 probands DNA sequence analyses 9 sarcomere protein genes 3 other ( GLA , PRKAG2 LAMP2 )...
We investigated the hypothesis that a cardioprotective, antiarrhythmic effect might be obtained by brief ischemia of remote part body before heart. Regional (RI) was induced in isolated Langendorff-perfused rat hearts: group I, 30-min RI and reperfusion (control hearts; n = 18); II, 5-min (a reference “classic” ischemic preconditioning; 12); III, preconditioning with vivo 10-min limb (LI) perfused heart ( 20). A significant decrease arrhythmia found groups II III compared I P < 0.02)....
Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin (CASQ2) gene mutations. To define how CASQ2 mutations cause CPVT, we produced and studied mice carrying human D307H missense mutation (CASQ307/307) CASQ2-null (CASQΔE9/ΔE9). Both identical consequences. Young mutant had structurally normal hearts but stress-induced arrhythmias; aging hypertrophy reduced contractile function. Mutant...
Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed mitochondrial dysfunction fibrosis, both of which aggravated angiotensin. Caloric restriction (CR) cardioprotective in animal models disease through its catabolic activity activation the expression adaptive genes. We hypothesized heart; this effect involves...