Tim Seidler
A5040071666- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Signaling Pathways in Disease
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Coronary Interventions and Diagnostics
- Pluripotent Stem Cells Research
- Medical Imaging Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
University of Göttingen
2016-2025
Justus-Liebig-Universität Gießen
2024-2025
Kerckhoff Klinik
2024-2025
German Centre for Cardiovascular Research
2017-2025
Sequoia (United States)
2024
SEQUOIA (Italy)
2024
Universitätsmedizin Göttingen
2014-2024
Nephrologisches Zentrum Goettingen
2020-2022
Amsterdam UMC Location University of Amsterdam
2019
King's College London
2017
Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack evidence regarding its effect on mortality. Download PDF Research Summary. In this multicenter trial, patients with acute myocardial infarction complicated by for whom early revascularization was planned were randomly assigned to receive ECLS plus usual medical (ECLS group) or alone (control group). The primary outcome death from any cause at 30 days. Safety outcomes...
Background— Hemodynamic load regulates myocardial function and gene expression. We tested the hypothesis that afterload preload, despite similar average load, result in different phenotypes. Methods Results— Afterload preload were compared mice with transverse aortic constriction (TAC) aortocaval shunt (shunt). Compared sham mice, 6 hours after surgery, systolic wall stress (afterload) was increased TAC (+40%; P <0.05), diastolic (preload) (+277%; <0.05) (+74%; mean total similarly...
Data assessing the long-term safety and efficacy of mavacamten treatment for symptomatic obstructive hypertrophic cardiomyopathy are needed. The authors sought to evaluate interim results from EXPLORER-Long Term Extension (LTE) cohort MAVA-LTE (A Long-Term Safety Study Mavacamten in Adults Who Have Completed EXPLORER-HCM; NCT03723655). After or placebo withdrawal at end parent EXPLORER-HCM (Clinical Evaluate [MYK-461] With Symptomatic Obstructive Hypertrophic Cardiomyopathy; NCT03470545),...
Long-term safety and efficacy of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) are unknown. MAVA-LTE (NCT03723655) is an ongoing, 5-year, open-label extension study designed to evaluate the long-term effects mavacamten.
Abstract Cardiomyocytes can be implanted to remuscularize the failing heart 1–7 . Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated hypothesis that epicardial engineered muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes stromal cells structurally functionally chronically limiting effects in rhesus macaques. After confirmation of...
The predominant cardiac Ca2+/calmodulin-dependent protein kinase (CaMK) is CaMKIIdelta. Here we acutely overexpress CaMKIIdeltaC using adenovirus-mediated gene transfer in adult rabbit ventricular myocytes. This circumvents confounding adaptive effects transgenic mice. expression and activation state (autophosphorylation) were increased 5- to 6-fold. Basal twitch contraction amplitude kinetics (1 Hz) not changed versus LacZ expressing However, the contraction-frequency relationship was more...
Abstract Aims Myocardial fibrosis (MF) might represent a key player in pathophysiology of heart failure aortic stenosis (AS). We aimed to assess its impact on left ventricular (LV) remodelling, recovery, and mortality after transcatheter valve implantation (TAVI) different AS subtypes. Methods results One hundred patients with severe were prospectively characterized clinically echocardiographically at baseline (BL), 6 months, 1 year, 2 years following TAVI. Left biopsies harvested...
Right heart catheterization using exercise stress is the reference standard for diagnosis of failure with preserved ejection fraction (HFpEF) but carries risk invasive procedure. We hypothesized that real-time cardiac magnetic resonance (RT-CMR) imaging pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary noninvasive alternative diagnosing HFpEF.The HFpEF-Stress trial (CMR Exercise Stress Testing in HFpEF; URL: https://www.clinicaltrials.gov; Unique...
Severe tricuspid regurgitation (TR) has limited treatment options and is associated with high morbidity mortality.We evaluated the safety effectiveness of Cardioband valve reconstruction system from ongoing European single-arm, multicentre, prospective TriBAND post-market clinical follow-up study.Eligible patients had chronic symptomatic functional TR despite diuretic therapy were deemed candidates for transcatheter repair by local Heart Team.Sixty-one ≥severe TR. At baseline, 85% in NYHA...
Despite their remarkable performance, deep neural networks remain unadopted in clinical practice, which is considered to be partially due lack explainability. In this work, we apply attribution methods a pre-trained network (DNN) for 12-lead electrocardiography classification open "black box" and understand the relationship between model prediction learned features. We classify data from public set assign "relevance score" each sample of classified signals. This allows analyzing what during...
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Abstract Background and Aims There is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was evaluate effect implementing BENCHMARK best practices on efficiency safety TAVI in 28 sites 7 European countries. Methods This a with severe symptomatic stenosis (AS) balloon-expandable valves before after implementation practices. Principal objectives were reduce hospital length stay (LoS)...
ABSTRACT Interleukin (IL)‐18 is the interferon‐γ‐inducing factor and has potent proinflammatory activities. IL‐18 been recently implicated in atherosclerotic plaque instability myocardial ischemia‐reperfusion injury. However, it unknown whether expression increased human myocardium or if any role heart failure. We analyzed of IL‐18, its receptor IL‐18Rα, endogenous inhibitor, binding protein (IL‐18BP) tissue from patients with end‐stage failure (ischemic dilated cardiomyopathy) controls by...
Machine learning (ML) is a powerful tool for identifying and structuring several informative variables predictive tasks. Here, we investigated how ML algorithms may assist in echocardiographic pulmonary hypertension (PH) prediction, where current guidelines recommend integrating parameters.In our database of 90 patients with invasively determined artery pressure (PAP) corresponding estimations PAP obtained within 24 hours, trained applied five (random forest classification trees, random...
Abstract Aims Health data captured by commercially available smart devices may represent meaningful patient‐reported outcome measures (PROMs) in heart failure (HF) patients. The purpose of this study was to test hypothesis evaluating the feasibility a new telemonitoring concept for patients following initial HF hospitalization. Methods and results We designed cardio patient monitoring platform (CPMP) that comprised mobile iOS‐based applications patients' smartphone/smartwatch equivalent...
Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces hypercontractility in obstructive hypertrophic cardiomyopathy. We present prespecified analysis of the pharmacokinetics, pharmacodynamics, and safety aficamten SEQUOIA‐HCM (Safety, Efficacy, Quantitative Understanding Obstruction Impact Aficamten HCM). Methods Results A total 282 patients with cardiomyopathy were randomized 1:1 to daily (5–20 mg) or placebo between February 1, 2022, May 15, 2023. dosing targeted...
Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes the PASCAL system in post-market setting have not been established. The authors report 30-day and 1-year outcomes from MiCLASP (Transcatheter Repair of Regurgitation Edwards Transcatheter Valve System) European clinical follow-up study. Patients symptomatic, clinically significant MR were prospectively enrolled. primary safety...
Post-cardiac arrest myocardial dysfunction is a common phenomenon after return of spontaneous circulation (ROSC) and contributes to hemodynamic instability low survival rates cardiac arrest. Mild hypothermia for 24 h ROSC has been shown significantly improve neurologic recovery rates. In the present study we investigate influence therapeutic on parameters in resuscitated patients contractility failing human myocardium. We analyzed data from 200 survivors during period. The initial LVEF was...
Calcineurin/NFAT signaling is involved in multiple aspects of skeletal muscle development and disease. The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5, MRF4 specify the lineage. Here we show that calcineurin/NFAT (nuclear factor activated T cells) required for primary myogenesis by transcriptional cooperation with MyoD. myogenin expression differentiating myoblasts, where regulatory MyoD synergistically cooperates NFATc2/c3 at promoter. Using gel shift...
Abstract Aims This study was designed to evaluate the safety, tolerability and haemodynamic effects of BMS ‐986231, a novel second‐generation nitroxyl donor with potential inotropic, lusitropic vasodilatory in patients hospitalized decompensated heart failure reduced ejection fraction ( HFrEF ). Methods results Forty‐six were enrolled into four sequential dose‐escalation cohorts this double‐blind, randomized, placebo‐controlled Phase 2a study. Patients baseline pulmonary capillary wedge...
ABSTRACT Aims The REDUCE‐LAP II trial demonstrated adverse outcomes after interatrial shunt device (IASD) placement in heart failure with preserved ejection fraction (HFpEF) attributed to latent pulmonary vascular disease (PVD). We hypothesized that exercise stress cardiovascular magnetic resonance (CMR) imaging could provide non‐invasive characterization of cardiac and physiology for improved patient selection. Methods results HFpEF‐Stress prospectively enrolled 75 patients exertional...