Garrie J. Haas
A5001119371- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Atrial Fibrillation Management and Outcomes
- Adrenal and Paraganglionic Tumors
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
The Ohio State University
2014-2025
Lung Institute
2004-2025
The Ohio State University Wexner Medical Center
2011-2024
Tufts Medical Center
2023
Tufts University
2023
Christchurch Hospital
2010
University of Otago
2010
The Alfred Hospital
2010
Scripps Clinic
2010
Auckland City Hospital
2010
BACKGROUND Endothelin is a family of potent vasoconstrictor peptides vascular endothelial origin. Although it has been proposed that the effects endothelin are produced at local level, increased plasma concentration identified in cardiovascular disorders. METHODS AND RESULTS We tested whether immunoreactive endothelin-1 could be detected by radioimmunoassay congestive heart failure patients and levels correlated with hemodynamic characteristics. Twenty (New York Heart Association class...
Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study physician-directed patient self-management system targeting left atrial pressure.Forty patients with reduced or preserved ventricular ejection fraction and history New York Heart Association class III IV failure acute decompensation were implanted an investigational pressure monitor, readings acquired twice daily....
An interatrial shunt may provide an autoregulatory mechanism to decrease left atrial pressure and improve heart failure (HF) symptoms prognosis.
The relative sensitivity and unexplained detection rate of changes in intrathoracic impedance has not been compared with standard heart failure (HF) monitoring using daily weight changes. Fluid Accumulation Status Trial (FAST) prospectively followed 156 HF patients implanted cardioverter-defibrillator or cardiac resynchronization therapy defibrillator devices modified to record a blinded fashion for 537±312 days. Daily were used calculate fluid index that could be prespecified threshold....
The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. study returns results to probands and, when indicated, relatives. While both American College Medical Genetics and Genomics/Association for Molecular Pathology ClinGen's MYH7-cardiomyopathy specifications provide relevant guidance variant interpretation, further gene- disease-specific considerations were required cardiomyopathy. To this end, we tailored ClinGen...
<h3>Importance</h3> Idiopathic dilated cardiomyopathy (DCM) aggregates in families, and early detection at-risk family members can provide opportunity to initiate treatment prior late-phase disease. Most studies have included only White patients, yet Black patients with DCM higher risk of heart failure–related hospitalization death. <h3>Objective</h3> To estimate the prevalence familial among probands age-specific cumulative first-degree relatives across race ethnicity groups. <h3>Design,...
This study was performed to examine cognitive function in patients with end-stage heart failure, identify possible cardiovascular factors associated function, and evaluate changes a subgroup of who received transplantation. An extensive battery neuropsychological tests were given 62 cardiac failure as part their evaluation for Most consecutive referrals, not selected because complaints. A small transplanted (n = 7) non-transplanted 4) repeat examination. At initial examination, approximately...
Importance Black patients with dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, but most DCM genetic data are from patients. Objective To compare the rare variant architecture of by genomic ancestry within a diverse population DCM. Design Cross-sectional study enrolling who self-identified as non-Hispanic Black, Hispanic, or June 7, 2016, to March 15, 2020, at 25 US advanced heart failure programs. Variants in 36 genes were adjudicated...
Abstract Aims This study was designed to evaluate the safety, tolerability and haemodynamic effects of BMS ‐986231, a novel second‐generation nitroxyl donor with potential inotropic, lusitropic vasodilatory in patients hospitalized decompensated heart failure reduced ejection fraction ( HFrEF ). Methods results Forty‐six were enrolled into four sequential dose‐escalation cohorts this double‐blind, randomized, placebo‐controlled Phase 2a study. Patients baseline pulmonary capillary wedge...
Background— The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype considered to have a genetic component. We hypothesize that most DCM, whether or nonfamilial, has basis, in which case genetics-driven approach identifying at-risk family members for clinical screening and early intervention could reduce morbidity mortality. Methods— On the basis this hypothesis, we launched National Heart, Lung, Blood Institute- Human Genome Research...
Background: Coronary angiography to identify coronary artery disease has been foundational distinguish the cause of dilated cardiomyopathy (DCM), including assignment idiopathic or ischemic cardiomyopathy. Late gadolinium enhancement (LGE) with cardiovascular magnetic resonance (CMR) emerged as an approach myocardial scar and etiology. Methods: The DCM Precision Medicine Study included patients left ventricular dilation dysfunction attributed DCM, after expert clinical review excluded other...
BACKGROUND: Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or heart transplant (LVAD/HT). DCM is known have genetic basis, but the association of rare variant genetics with has not been studied. METHODS: We analyzed clinical and sequence data from patients enrolled between 2016 2021 in US multisite Precision Medicine Study, which was geographically diverse, multiracial, multiethnic cohort. Clinical...
Abstract Background Peripartum cardiomyopathy (PPCM) presents substantial risk of maternal mortality, but underlying cause remains unsettled. Methods We compared the prevalence dilated (DCM)-relevant genetic variants in 452 female patients (probands) African and European ancestry (AA, EA) with PPCM or DCM who had been pregnant at least once. Pathogenic likely pathogenic (P/LP) were identified DCM-associated genes. Risk partial DCM, defined as left ventricular enlargement a ejection fraction...
BACKGROUND: Whether prolonged and excessive alcohol consumption contributes to dilated cardiomyopathy (DCM) remains uncertain. This study aimed describe the prevalence of use in patients with DCM their first-degree relatives (FDRs) determine if cumulative exposure associates DCM/partial or modifies association DCM-relevant rare variants. METHODS: All probands had DCM; FDRs were classified as without partial DCM. Alcohol was measured Use Disorder Identification Test-Consumption questionnaire...
BACKGROUND: Previous studies have speculated that a viral infection may act as trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe frequency patients with DCM who reported experiencing symptoms flu-like illness before their diagnosis and examine if this experience modified association between genetics DCM. METHODS: We analyzed data from family-based cross-sectional Study conducted 2016 2021. Self-reported...
Abstract Introduction The impact of induction immunosuppression on long‐term survival in heart transplant recipients is unclear. Over the past three decades, practices have varied as agents changed and experiences grew. We sought to evaluate effect contemporary with primary endpoint survival, utilizing national registry data. Methods queried United Network for Organ Sharing ( UNOS ) data all transplants from 1987 2012. restricted our analysis adult (≥18 yr) performed 2001–2011 (to allow...