A5036587108- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Sarcoidosis and Beryllium Toxicity Research
- Renal Transplantation Outcomes and Treatments
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Eosinophilic Disorders and Syndromes
- Genomics and Rare Diseases
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis C virus research
- Sleep and related disorders
- Genetic Associations and Epidemiology
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
New York Medical College
2020-2025
Westchester Medical Center
2020-2024
Health Net
2024
NYU Langone Health
2015-2023
Association Clinique et Thérapeutique Infantile du Val de Marne
2022-2023
Stanford University
2012-2022
New York University
2016-2020
Institute of Cardiology
2015
Stanford Medicine
2011-2014
CVPath Institute
2013
The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. study returns results to probands and, when indicated, relatives. While both American College Medical Genetics and Genomics/Association for Molecular Pathology ClinGen's MYH7-cardiomyopathy specifications provide relevant guidance variant interpretation, further gene- disease-specific considerations were required cardiomyopathy. To this end, we tailored ClinGen...
<h3>Importance</h3> Idiopathic dilated cardiomyopathy (DCM) aggregates in families, and early detection at-risk family members can provide opportunity to initiate treatment prior late-phase disease. Most studies have included only White patients, yet Black patients with DCM higher risk of heart failure–related hospitalization death. <h3>Objective</h3> To estimate the prevalence familial among probands age-specific cumulative first-degree relatives across race ethnicity groups. <h3>Design,...
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Background. Scarcity of donor hearts continues to be a challenge for heart transplantation (HT). The recently Food and Drug Administration–approved Organ Care System (OCS; Heart, TransMedics) ex vivo organ perfusion enables extension situ intervals thus may expand the pool. Because postapproval real-world outcomes OCS in HT are lacking, we report our initial experience. Methods. We retrospectively reviewed consecutive patients who received at institution post–Food Administration approval...
Importance Black patients with dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, but most DCM genetic data are from patients. Objective To compare the rare variant architecture of by genomic ancestry within a diverse population DCM. Design Cross-sectional study enrolling who self-identified as non-Hispanic Black, Hispanic, or June 7, 2016, to March 15, 2020, at 25 US advanced heart failure programs. Variants in 36 genes were adjudicated...
Re-endothelialization is delayed after drug-eluting stent (DES) implantation. In this setting, neointima more prone to become lipid laden and develop neoatherosclerosis (NA), potentially increasing plaque vulnerability.Optical coherence tomography near-infrared spectroscopy with intravascular ultrasound were used characterize NA in 65 (51 DES 14 bare-metal stents) consecutive symptomatic patients in-stent restenosis. Median duration poststent implantation was 33 months. Optical...
The clinical significance of variants in genes associated with inherited cardiomyopathies can be difficult to determine because uncertainty regarding population genetic variation and a surprising amount tolerance the genome even loss-of-function variants. We hypothesized that cardiomyopathy might particularly resistant accumulation variation.We analyzed rates single nucleotide all known from exomes >5000 individuals National Heart, Lung, Blood Institute's Exome Sequencing Project, as well...
Background: Coronary angiography to identify coronary artery disease has been foundational distinguish the cause of dilated cardiomyopathy (DCM), including assignment idiopathic or ischemic cardiomyopathy. Late gadolinium enhancement (LGE) with cardiovascular magnetic resonance (CMR) emerged as an approach myocardial scar and etiology. Methods: The DCM Precision Medicine Study included patients left ventricular dilation dysfunction attributed DCM, after expert clinical review excluded other...
Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy limited by pathological vascular remodeling. Using a systems approach, we identified role network hub gene glutathione peroxidase-1 (GPX1) in remodeling following human blood vessel stenting. Constitutive deletion of Gpx1 atherosclerotic mice recapitulated phenotype increased smooth muscle cell (VSMC) proliferation plaque formation. In an independent patient cohort, variant pair...
The impact of the new heart allocation policy, which prioritizes acutely ill patients on temporary mechanical circulatory support and provides broader sharing donor organs, patient graft survival in combined kidney transplantation (HKT) is unknown.In United Network for Organ Sharing data, were divided groups before after policy change (OLD, January 1, 2015 to October 17, 2018, N=533; NEW, 18, 2018 December 31, 2020, N=370). Propensity score matching was performed utilizing recipient...
BACKGROUND: Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or heart transplant (LVAD/HT). DCM is known have genetic basis, but the association of rare variant genetics with has not been studied. METHODS: We analyzed clinical and sequence data from patients enrolled between 2016 2021 in US multisite Precision Medicine Study, which was geographically diverse, multiracial, multiethnic cohort. Clinical...
ObjectiveTo review the outcomes of axillary artery (AX) and femoral (FA) cannulation for veno-arterial extracorporeal membraneous oxygenation (VA-ECMO).MethodsFrom 2009 to 2019, 371 patients who were supported with VA-ECMO cardiogenic shock compared based on arterial site: AX (n = 218) versus FA 153).ResultsPatients in group older (61 years vs 58 years, P .011), had a greater prevalence peripheral vascular disease (13.8% 5.2%, .008), less likely have undergone cardiopulmonary resuscitation...