A5009759231- Neuroblastoma Research and Treatments
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- Cyclization and Aryne Chemistry
- Diversity and Career in Medicine
- Health and Medical Research Impacts
- Innovations in Medical Education
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Alzheimer's disease research and treatments
- Child and Adolescent Health
- Virus-based gene therapy research
- Electron Spin Resonance Studies
- 14-3-3 protein interactions
- Clinical Reasoning and Diagnostic Skills
- Mitochondrial Function and Pathology
- Neurology and Historical Studies
- Adolescent and Pediatric Healthcare
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- RNA regulation and disease
Office of Extramural Research
2023-2024
National Institutes of Health
2018-2024
ORCID
2024
Office of the Director
2024
National Institute of Neurological Disorders and Stroke
2018-2023
University of Rochester Medical Center
2010-2022
Children's Hospital of Philadelphia
2022
Harvard University
1987-2022
University of Pennsylvania
2022
Massachusetts General Hospital
2022
The aborted trial of semagacestat has led some to invoke unanticipated effects γ-secretase inhibition on formation amyloid β. However, the many substrates for γ-secretases and varied biological each resultant cleavage products make ascribing causality much more complex than that.
To test the hypotheses that women in medical school dean-level (decanal) positions occupy lower-rank and more image- education-focused than men, state woman-led schools have decanal positions.Data were collected on September 10-18, 2016, from Web sites of 136 allopathic, U.S. accredited by Liaison Committee Medical Education represented roster MD programs United States with full accreditation as June 22, 2016. Statistical significance differences between comparison groups was assessed using...
An increasing number of medical schools have implemented or are considering implementing scholarly activity programs as part their undergraduate curricula. The goal these is to foster students' analytical skills, enhance self-directed learning and oral written communication ultimately train better physicians. In this article, the authors describe approach activities at a school that requires where it elective. Both dealt with significant challenges including orienting students complex...
Prevention by nerve growth factor (NGF) of apoptotic death in neural cells has been variously ascribed to binding NGF its low-affinity (p75) or high-affinity (trkA) receptor a cooperative interaction between the two. In series studies using, turn, neuroblastoma cell lines that express only p75, mutant species bind selectively either p75 trkA, and polyclonal antibody binds NGF-binding domain we demonstrate is both necessary sufficient for abrogation apoptosis treated with antimitotic agents.
Hypoxia-induced gene expression is a critical determinant of neuron survival after stroke. Understanding the cell autonomous genetic program controlling adaptive and pathological transcription could have important therapeutic implications. To identify factors that modulate delayed neuronal apoptosis hypoxic injury, we developed an in vitro culture model recapitulates these divergent responses characterized sequence changes using microarrays. Hypoxia induced disproportionate number bZIP...
Abstract Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number cancers, making PRMTs potential therapeutic targets. But it remains not well understood how impact specific oncogenic pathways. We previously identified as important regulators cell growth neuroblastoma, deadly childhood tumor the sympathetic nervous system. Here, we demonstrate critical role for PRMT1 neuroblastoma survival. depletion decreased ability murine sphere cells to grow and...
Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells. In the present study, we examine mechanisms of this and demonstrate its relevance for in vivo situation. Four hours after NCS treatment, 23-kDa cleavage product was detected whole cell lysates <i>bcl-2</i>–transfected contrast, <i>bcl-2</i> transfection protected cells cisplatin-induced apoptosis, cisplatin treatment did not result...
Many U.S. medical schools offer students the opportunity to undertake laboratory or clinical research another form of scholarly project over summer months, yet few require this as a prerequisite for graduation, and even fewer provide comprehensive didactic material in preparation performance such an integrated component their curricula. The authors describe Scholarly Project Initiative University Pittsburgh School Medicine, novel, longitudinal, required program. program will aim all with...
Amplification or overexpression of MYCN is associated with poor prognosis human neuroblastoma. We have recently defined a MYCN-dependent transcriptional signature, including protein arginine methyltransferase 1 (PRMT1), which identifies subgroup patients high-risk disease. Here we provide several lines evidence demonstrating PRMT1 as novel regulator and implicating potential therapeutic target in neuroblastoma pathogenesis. First, observed strong correlation between levels primary tumors....
The dopamine analogue 6-hydroxydopamine (6-OHDA) is selectively toxic to catecholaminergic neurons. Because of its selectivity for neuroblastic cells in the sympathetic nervous system lineage, 6-OHDA has been suggested as a chemotherapeutic agent targeted treatment patients with neuroblastoma. We tested hypothesis that toxicity caused by interaction serum ferric transferrin (Fe-TF) resulting release iron. further hypothesized this iron, through redox-cycling 6-OHDA, triggers generation...
✓ The authors report an unusual case of a 2-year-old boy with 3-month history episodic rightward anterolateral head tilt and large-amplitude positional anteroposterior bobbing reminiscent bobble—head doll syndrome. This child experienced sudden onset drop attacks then, within several hours, deep coma. causative lesion was contrast-enhancing, partially cystic third ventricular mass, which ultimately obstructed the aqueduct, producing profound obstructive hydrocephalus. An emergency...