A5045842631- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Nuclear Structure and Function
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Imaging and Diagnostics
- Thyroid Disorders and Treatments
- Pharmacological Effects and Assays
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- Hormonal Regulation and Hypertension
- Ion channel regulation and function
- Acute Myocardial Infarction Research
University of Bari Aldo Moro
2016-2025
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2024
Presidio Ospedaliero
2024
East Carolina University
2007
Case Western Reserve University
2006
Université Laval
2006
Ministero della Salute
2005
Fondazione Salvatore Maugeri
1996-2003
Istituti di Ricovero e Cura a Carattere Scientifico
1998-1999
Ospedale San Paolo
1998
Brugada syndrome is associated with a high risk of sudden cardiac death and caused by mutations in the voltage-gated sodium channel gene. Previously, R282H-SCN5A mutation gene was identified patients syndrome. In family carrying mutation, an asymptomatic individual had common H558R-SCN5A polymorphism on separate chromosomes. Therefore, we hypothesized that could rescue mutation.In heterologous cells, expression alone did not produce current. However, coexpressing produced significantly...
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Background —Depressed baroreflex sensitivity obtained by means of a phenylephrine test plays prognostic role in patients with previous myocardial infarction. Our purpose was to evaluate the correlation and agreement between that two noninvasive methods: α-index sequence analysis. Methods Results —The measured spectral analysis RR systolic blood pressure variabilities both high- low-frequency bands; sequences were identified from simultaneously recorded time series which concurrently...
To obtain data relating to the reproducibility of time and frequency domain measurements obtained from 10-min ECG recordings.Eighteen normal volunteers underwent evaluations heart rate variability 2 weeks 7 months after baseline analysis. The parameters were mean NN, standard deviation NN intervals, percentage successive intervals > 50 ms root square difference intervals. (total power, low frequency, high frequency) made by means both Fast Fourier Transform algorithm (FFT) autoregressive...
Objective: The aims of this study were to determine the relationships between oscillations in systolic blood pressure and heart period at different breathing frequencies investigate role sympathetic contribution relationship. Methods: Fourteen healthy volunteers underwent three randomized periods controlled 6, 10 16 breaths/min. ECG (RR), respiratory signal (RESP) (SBP) continuously recorded. component RR SBP related respiration (RRResp SBPResp) was defined by means uni- bivariate spectral...
Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients cardiovascular disease. Aim. To evaluate the prognostic role of function deficiency chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients stable CHF receiving conventional therapy, all whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, Na+, hemoglobin, NT-proBNPs,...
Aims To evaluate the independent prognostic role of two‐dimensional (2D) strain measures reflecting global longitudinal left ventricular ( LV ) systolic function in outpatients affected by chronic heart failure CHF ). Methods and results Global GLS was assessed 308 , analyzing standard views with 2D speckle tracking technique. During a mean follow‐up 26 ± 13 months 37 patients died (29 due to cardiovascular causes), 10 underwent transplantation, 75 experienced at least 1 episode...
Raising the suspicion of amyloid cardiomyopathy (AC) is essential to orient additional tests and achieve an early diagnosis before development clinically overt disease.1,2 Notably, echocardiography technique with greatest potential raise AC by detecting specific signs ('red-flags') cardiac infiltration.3 However, epidemiology echocardiographic red-flags in general population patients referred without clinical their diagnostic accuracy remain unknown.4,,5 This a national, multicentre,...
Postzygotic activating PIK3CA variants cause several phenotypes within the PIK3CA-related overgrowth spectrum (PROS). Variant strength, mosaicism level, specific tissue involvement and overlapping disorders are responsible for disease heterogeneity. We explored these factors in 150 novel patients an expanded cohort of 1007 PIK3CA-mutated patients, analysing our new data with previous literature to give a comprehensive picture.We performed ultradeep targeted next-generation sequencing (NGS)...
Cardiomyopathies are a heterogeneous group of primary diseases the myocardium, including hypertrophic cardiomyopathy (HCM), dilated (DCM), and arrhythmogenic right ventricular (ARVC), with higher morbidity mortality. These genetically diverse associated rare mutations in large number genes, many which overlap among phenotypes. To better investigate genetic between these three phenotypes to identify new genotype-phenotype correlations, we designed custom gene panel consisting 115 genes known...
Mutations in the lamin A/C gene (LMNA) were associated with dilated cardiomyopathy (DCM) and, recently, related to severe forms of arrhythmogenic right ventricular (ARVC). Both genetic and phenotypic overlap between DCM ARVC was observed; molecular pathomechanisms leading cardiac phenotypes caused by LMNA mutations are not yet fully elucidated. This study involved a large Italian family, spanning 4 generations, different phenotypes, including ARVC, DCM, system conduction defects,...
Mutations in the LMNA (lamin A/C) gene have been associated with neuromuscular and cardiac manifestations, but clinical implications of these signs are not well understood.To learn more about natural history LMNA-related disease.Observational study.13 centers Italy from 2000 through 2018.164 carriers an mutation.Detailed cardiologic neurologic evaluation at study enrollment for a median 10 years follow-up.The age was 38 years, 51% participants were female. Neuromuscular manifestations...
The use of beta-blocker therapy in cardiac amyloidosis (CA) is debated. We aimed at describing patterns prescription through a nationwide survey.From 11 referral centres, we retrospectively collected data CA patients with first evaluation after 2016 (n = 642). Clinical characteristics and last were collected, focus on medical therapy. For whom was started, stopped, or continued between evaluation, the main reason for management requested. Median age study population 77 years; 81% men....
(1) Background: Glucagone-Like Peptide-1 Receptor Agonists (GLP-1 RAs) are incretine-based medications recommended in the treatment of type 2 Diabetes Mellitus (DM2) with atherosclerotic cardiovascular disease (ASCVD) or high very (CV) risk. However, knowledge direct mechanism GLP-1 RAs on cardiac function is modest and not yet fully elucidated. Left ventricular (LV) Global Longitudinal Strain (GLS) Speckle Tracking Echocardiography (STE) represents an innovative technique for evaluation...