A5045797338- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Diversity and Career in Medicine
- Non-Invasive Vital Sign Monitoring
- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
The Ohio State University Wexner Medical Center
2014-2024
The Ohio State University
2013-2022
Lung Institute
2004-2022
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2019
Columbus Oncology and Hematology Associates
2019
Ohio State University Hospital
1991-2017
Gwinnett Medical Center
2017
University of Colorado Anschutz Medical Campus
2017
Azusa Pacific University
2017
Denver Health Medical Center
2017
The assessment of myocardial viability has been used to identify patients with coronary artery disease and left ventricular dysfunction in whom coronary-artery bypass grafting (CABG) will provide a survival benefit. However, the efficacy this approach is uncertain.In substudy who were enrolled randomized trial medical therapy or without CABG, we single-photon-emission computed tomography (SPECT), dobutamine echocardiography, both assess on basis prespecified thresholds.Among 1212 trial, 601...
BACKGROUND Endothelin is a family of potent vasoconstrictor peptides vascular endothelial origin. Although it has been proposed that the effects endothelin are produced at local level, increased plasma concentration identified in cardiovascular disorders. METHODS AND RESULTS We tested whether immunoreactive endothelin-1 could be detected by radioimmunoassay congestive heart failure patients and levels correlated with hemodynamic characteristics. Twenty (New York Heart Association class...
Abstract Behavioral contexts can evoke a variety of autonomic modes response, characterized by reciprocal, coactive, or independent changes in the divisions. In present study, we investigated reactive control heart response to psychological stressors, using quantitative methods for analyzing single and double blockades, through use noninvasive indices based on period variability systolic time intervals. Analysis effects pharmacological blockades revealed an overall pattern increased...
Heart period, systolic time intervals, low and high frequency heart period variability, blood pressure, respiration were measured in female subjects under three drug conditions (saline, atropine sulfate, metoprolol) while sitting standing on consecutive days. Following preinfusion baseline recordings, saline, metoprolol (14 mg), or sulfate (2 mg) was infused for 15 min (by using a double-blind procedure). Recordings taken during postinfusion response to an orthostatic stressor (standing...
Successful autologous skeletal myoblast transplantation into infarcted myocardium in a variety of animal models has demonstrated improvement cardiac function. We evaluated the safety and feasibility transplanting myoblasts patients undergoing concurrent coronary artery bypass grafting (CABG) or left ventricular assist device (LVAD) implantation. In addition, we sought to gain preliminary information on graft survival any associated changes function.Thirty with history ischemic cardiomyopathy...
Abstract Purpose: This phase II study was undertaken to assess objective response and toxicity of histone deacetylase inhibitor depsipeptide in patients with neuroendocrine tumors. Experimental Design: A total 15 metastatic tumors received a 4-hour i.v. infusion at 14 mg/m2 on days 1, 8, every 28 days. Tumor assessed 8-week intervals using Response Evaluation Criteria Solid Tumors. Most were chemo-naïve (n = 12) but receiving long-acting octreotide for carcinoid syndrome 11). All had...
Background— Human gene variants affecting ion channel biophysical activity and/or membrane localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism for many human arrhythmia remains undefined despite more than a decade of investigation. Posttranslational modulation proteins is essential normal function. Importantly, aberrant myocyte signaling has been defects in posttranslational modifications and disease. We recently identified novel pathway regulation...
The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. study returns results to probands and, when indicated, relatives. While both American College Medical Genetics and Genomics/Association for Molecular Pathology ClinGen's MYH7-cardiomyopathy specifications provide relevant guidance variant interpretation, further gene- disease-specific considerations were required cardiomyopathy. To this end, we tailored ClinGen...
There is conflicting evidence as to the impact of mental health treatment on outcomes in patients with heart disease. The aim this study was examine whether individuals who received for anxiety or depression after being hospitalized ischemic disorders failure had a reduced frequency rehospitalizations, emergency department visits, mortality compared those did not receive treatment.
The following topics are dealt with: the next era of examination and management patient with cardiovascular disease; importance technology in rehabilitation; wearable applications Parkinson's sensor for functional assessment after stroke.
The role of IKCa in cardiac repolarization remains controversial and varies across species. relevance the current as a therapeutic target is therefore undefined. We examined cellular electrophysiologic effects blockade controls, chronic heart failure (HF) HF with sustained atrial fibrillation. used perforated patch action potential recordings to maintain intrinsic calcium cycling. blocker (apamin 100 nM) was examine ventricular myocytes. A canine tachypacing induced model (1 4 months, n = 5...
Background Chimeric antigen receptor T-cell (CAR-T) infusion is associated with early toxicity. Yet, whether toxicity development holds ramifications for long-term outcomes unknown. Methods From a large cohort of consecutive adult patients treated CAR-T therapies relapsed or refractory lymphomas from 2016 to 2019, we assessed progression-free survival (PFS), by (cytokine release syndrome (CRS), neurotoxicity, cardiotoxicity]. We also the relationship objective disease response, and overall...
Objectives The voltage-dependent L-type calcium channel α-subunit 1c (Cav1.2, CACNA1C) undergoes extensive mRNA splicing, leading to numerous isoforms with different functions. blockers are used in the treatment of hypertension and arrhythmias, but response varies between individuals. We have studied interindividual variability expression splicing CACNA1C, 65 heart tissue samples, taken from transplant recipients. Methods Splice variants were measured quantitatively by polymerase chain...
Successful autologous skeletal myoblast transplantation into infarcted myocardium in a variety of animal models has demonstrated improvement cardiac function. We evaluated the safety and feasibility transplanting myoblasts patients undergoing concurrent coronary artery bypass grafting (CABG) or left ventricular assist device implantation (LVAD). In addition, we sought to gain preliminary information on graft survival any potential Eighteen with history ischemic cardiomyopathy participated...
Background— The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity health and disease. In fact, human mutations cytoskeletal elements are tightly linked to pathologies, including myopathies, aortopathies, dystrophies. Conversely, the link between protein dysfunction electric activity is not well understood often overlooked arrhythmia field. Methods Results— Here, we uncover a new mechanism for regulation of membrane excitability. We report that βII spectrin, an...