A5040238670- Smoking Behavior and Cessation
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- School Health and Nursing Education
- Global Cancer Incidence and Screening
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Boron Compounds in Chemistry
- Health disparities and outcomes
- Radiopharmaceutical Chemistry and Applications
- T-cell and B-cell Immunology
- Food Security and Health in Diverse Populations
- Air Quality and Health Impacts
- Public Health Policies and Education
- Substance Abuse Treatment and Outcomes
- Cervical Cancer and HPV Research
- Noise Effects and Management
- HIV-related health complications and treatments
- COVID-19 and Mental Health
- Viral-associated cancers and disorders
- Pediatric health and respiratory diseases
- Cardiac Health and Mental Health
- Congenital Heart Disease Studies
- Human-Animal Interaction Studies
- Media Influence and Health
East Carolina University
2025
Hunter College
2025
The Ohio State University
2015-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2009-2020
Old Dominion University
2018
James Cook University
2018
National Heart Lung and Blood Institute
2015
Johns Hopkins University
2015
National Institutes of Health
2015
Rush University Medical Center
2015
Depression predicts morbidity and mortality among individuals who have coronary heart disease (CHD), there is increasing evidence that depression may also act as an antecedent to CHD. The studies reported a relationship between CHD incidence or either were restricted men only analyzed women together. present investigation was conducted evaluate the differential effect on in men.We data from 5007 2886 enrolled first National Health Nutrition Examination Survey (NHANES I) free of at 1982-1984...
Human natural killer (NK) cells originate from CD34(+) hematopoietic progenitor cells, but the discrete stages of NK cell differentiation in vivo have not been elucidated. We identify and functionally characterize, human lymph nodes tonsils, four developmental intermediates spanning continuum a to mature cell. Analyses each intermediate stage for CD34, CD117, CD94 surface expression, lineage potentials, capacity cytokine production cytotoxicity, ETS-1, GATA-3, T-BET expression provide...
To determine the impact of longer periods between biopsy-confirmed breast cancer diagnosis and initiation treatment (Dx2Tx) on survival.This study was a noninterventional, retrospective analysis adult female North Carolina Medicaid enrollees diagnosed with from January 1, 2000, through December, 31, 2002, in linked Central Cancer Registry-Medicaid Claims database. Follow-up data were available July 2006. Cox proportional hazards regression models constructed to evaluate survival delaying ≥...
Objective Prior studies of quality life among cardiac patients have examined mostly men. This study evaluated gender differences in and the degree to which social support was associated with life. Methods A sample 536 (35% women) recruited during a 14-month period from inpatient cardiology service University-based hospital. Participants completed assessments at baseline 3-month intervals over subsequent 12 months, for total 5 assessments. Measures each assessment included [Mental Component...
We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting an in-frame partial tandem duplication (PTD) exons 5 through 11 in the absence partner gene, occurring approximately 4%-7% patients with acute myeloid (AML) normal cytogenetics, associated poor prognosis. The mechanism by which MLL PTD contributes to aberrant hematopoiesis and/or is unknown. To examine this, we generated mouse knockin model murine Mll were targeted...
Abstract Purpose: The purpose of the present study was to evaluate anti–epidermal growth factor monoclonal antibody (mAb) cetuximab (IMC-C225) as a delivery agent for boron neutron capture therapy (BNCT) human epidermal receptor (EGFR) gene-transfected rat glioma, designated F98EGFR. Experimental Design: A heavily boronated polyamidoamine dendrimer chemically linked by means heterobifunctional reagents N-succinimidyl 3-(2-pyridyldithio)-propionate and N-(k-maleimido undecanoic...
The U.S. Public Health Service smoking cessation clinical practice guideline is the accepted gold standard for treatment. It offers evidence-based treatment recommendations all clinicians to deliver patients at each visit. Despite release of and publication Healthy People 2010, health care providers still may not appropriately counsel quit smoking. Furthermore, disparities exist among smokers who are assisted by their providers. present study tested an association between selected...
Abstract Our preclinical work showed a dramatic synergy between interleukin-12 (IL-12) and trastuzumab for stimulation of natural killer cell cytokine secretion. We aimed to determine the safety profile IL-12 when given in combination with paclitaxel patients metastatic HER2-overexpressing cancers. Paclitaxel was i.v. at 175 mg/m2 every 3 weeks. Trastuzumab on day 1 each week (4 mg/kg initially 2 thereafter) injections days 5 starting cycle 2. This trial accrued 21 HER2-positive tumors...
Abstract BACKGROUND: The objectives of this study were to evaluate survival among current smokers, former and never smokers who are diagnosed with non–small cell lung cancer (NSCLC). METHODS: included patients participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, former, compared respect overall by fitting Cox regression models. RESULTS: Data from 4200 examined, including 618 1483 380 quit 1 12 months before diagnosis, 1719 >12 diagnosis. Among stage...
Screening for breast and colorectal cancer has resulted in reductions mortality; however, questions remain regarding how these interventions are being diffused to all segments of the population. If an intervention is less amenable diffusion, it could be associated with disparities mortality rates, especially rural vs urban areas.
Abstract Purpose: The incidence of non-Hodgkin's lymphoma (NHL), the fifth most common malignancy in United States, has increased over 70% last 30 years. Fifty percent to 75% patients with low-grade or follicular NHL respond rituximab therapy. However, responses are generally limited duration, and complete rare. Preclinical work suggests that human recombinant interleukin-2 (rIL-2; aldesleukin, Proleukin) enhances efficacy. Antibody-dependent cellular cytotoxicity (ADCC) is an important...
Abstract Purpose: The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron neutron capture therapy (BNCT) receptor-positive rat glioma, F98npEGFRvIII. Experimental Design: A heavily polyamido amine (PAMAM) dendrimer (BD) chemically linked L8A4 by two heterobifunctional reagents, N-succinimidyl 3-(2-pyridyldithio)propionate and N-(k-maleimidoundecanoic acid)hydrazide. For in vivo studies, F98 wild-type receptor-negative or EGFRvIII...
Tomato and soy products are hypothesized to reduce the risk of prostate cancer or enhance efficacy therapy. A study was completed determine if men with active will adhere a dietary intervention rich in tomato protein supplement (n = 41) recurrent, asymptomatic were randomized among 2 groups: Group 20) consumed (no soy) for Weeks 0 through 4, targeting minimum 25 mg lycopene/day. B 21) tomatoes) providing 40 g protein/day. For 4 8, all combined tomato-rich diet supplements. No grade II IV...
As future physicians capable of controlling tobacco dependence in the population, medical students are considered a main target for control interventions.This cross-sectional study reported on prevalence use (cigarettes and waterpipes) associated knowledge behaviour among 6th-year 2009-2010 from 6 schools Lebanon.The self-administered questionnaire based Global Health Professional Survey (GHPSS) core questions also enquired about training cessation approaches.All enrolled were asked to...
Not all smokers receive tobacco cessation advice from health care providers (HCPs) and, although factors associated with receiving HCP to quit smoking and the effectiveness of such have been examined, no recent study has explored differences between types HCPs (eg, physicians vs dentists). Our objective was determine prevalence HCP-delivered characteristics patients who any separately, a physician or dentist.This used data Sample Adult Core questionnaire, Family Cancer Control Module 2010...
Abstract Objective Although burnout has been linked to negative workplace‐level effects, prior studies have primarily focused on individuals rather than job‐related characteristics. This study sought evaluate variation in between agencies and quantify the relationship demands/resources among emergency medical services (EMS) professionals. Methods An electronic questionnaire was sent all licensed, practicing EMS professionals South Carolina. Work‐related measured using Copenhagen Burnout...