A5053202206- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mechanisms of cancer metastasis
- Plant Genetic and Mutation Studies
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Neuroblastoma Research and Treatments
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Boron Compounds in Chemistry
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Medical Imaging Techniques and Applications
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Histone Deacetylase Inhibitors Research
- Cerebrospinal fluid and hydrocephalus
- CNS Lymphoma Diagnosis and Treatment
Roswell Park Comprehensive Cancer Center
2016-2025
University at Buffalo, State University of New York
2013-2024
Jacobs (United States)
2017-2024
Jacobs Institute
2019
University at Albany, State University of New York
2016
Sidney Kimmel Comprehensive Cancer Center
2015
Fox Chase Cancer Center
2015
Smilow Cancer Hospital
2015
UCSF Helen Diller Family Comprehensive Cancer Center
2015
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2015
Primary and metastatic tumors of the central nervous system are a heterogeneous group neoplasms with varied outcomes management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy radiation as new standard for treating patients pure or mixed anaplastic oligodendroglioma harboring 1p/19q codeletion. For disease, increasing evidence supports efficacy stereotactic radiosurgery multiple lesions but low overall tumor volume. These...
For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations patients demonstrated prognostic value histologic phenotype, variability in outcomes within groups limited utility this system. Nonetheless, histology was only proven widely accessible tool available at time, thus it used for clinical trial entry criteria, therefore determined recommended treatment options. Research to identify molecular changes that underlie...
PURPOSE Despite intensive treatment with surgery, radiation therapy, temozolomide (TMZ) chemotherapy, and tumor-treating fields, mortality of newly diagnosed glioblastoma (nGBM) remains very high. SurVaxM is a peptide vaccine conjugate that has been shown to activate the immune system against its target molecule survivin, which highly expressed by cells. We conducted phase IIa, open-label, multicenter trial evaluating safety, immunologic effects, survival patients nGBM receiving plus...
Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been reported to antitumor activity in different malignancies and immunomodulatory effects. Herein, we report Tregs-targeting immune-promoting effect a class I specific HDAC inhibitor, entinostat, combination with either IL-2 murine renal cell carcinoma (RENCA) model or survivin-based vaccine therapy (SurVaxM) castration resistant prostate cancer (CR...
The gene encoding EGFR often is amplified in human gliomas, and the receptor itself has been considered as a potential target for specific delivery of therapeutic agents to brain tumors. purpose present study was investigate use chimeric MoAb cetuximab (IMC-C225), which directed against EGFRvIII, boron agent neutron capture therapy (NCT) As determined by 125I-cetuximab radioligand binding assays, F98 rat glioma cells, had transfected with (F98EGFR), expressed 1.60 ± 0.13 × 105 sites/cell Ka...
Abstract Recent evidence suggests that the thyroid hormone l-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin αVβ3. The contribution this recently described for and receptor-based stimulation cellular mitogen-activated protein kinase [MAPK; extracellular signal-regulated 1/2 (ERK1/2)] activity, to enhancement cell proliferation by was quantitated functionally immunologic means in three glioma lines exposed T4. At concentrations 1 100 nmol/L, T4...
Survivin is an anti-apoptotic protein that highly expressed in many cancers, including malignant gliomas. Preclinical studies established the conjugated survivin peptide mimic SurVaxM (SVN53-67/M57-KLH) could stimulate anti-tumor immune response against murine glioma vivo, as well human cells ex vivo. The current clinical study was conducted to test safety, immunogenicity and effects of vaccine. Recurrent patients whose tumors were survivin-positive, who had either HLA-A*02 or HLA-A*03 MHC...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Central Nervous System (CNS) Cancers provide interdisciplinary recommendations managing adult CNS cancers. Primary and metastatic brain tumors are a heterogeneous group of neoplasms with varied outcomes management strategies. These Insights summarize the Panel's discussion highlight notable changes 2015 update. This article outlines data provides insight into panel decisions regarding adjuvant radiation chemotherapy...
In 2010, an estimated 22,020 new cases of primary brain and other nervous system neoplasms were diagnosed in the United States, 1 approximately 13,140 deaths occurred from these tumors.The incidence malignant tumors has been increasing over past 30 years, especially elderly persons. 2 Metastatic disease to central (CNS) occurs much more frequently, with 10 times that tumors.Between 20% 40% patients systemic cancer will develop metastases.
The NCCN Guidelines for Central Nervous System Cancers provide multidisciplinary recommendations the clinical management of patients with cancers central nervous system. These Insights highlight recent updates regarding metastatic brain tumors using radiation therapy. Use stereotactic radiosurgery (SRS) is no longer limited to 3 or fewer lesions, because data suggest that total disease burden, rather than number predictive survival benefits associated technique. SRS increasingly becoming an...
Abstract Purpose: The abundance and biological contribution of cancer-associated fibroblasts (CAF) in glioblastoma (GBM) are poorly understood. Here, we aim to uncover its molecular signature, cellular roles, potential tumorigenesis implications. Experimental Design: We first applied single-cell RNA sequencing (RNA-seq) bioinformatics analysis identify characterize stromal cells with CAF transcriptomic features human GBM tumors. Then, performed functional enrichment vitro assays investigate...
In the year 2005, an estimated 18,500 new cases of primary brain and nervous system neoplasms will be diagnosed in United States. These tumors responsible for approximately 12,760 deaths. The incidence malignant has been increasing over past 25 years, especially elderly persons (rates are at about 1.2% each year). Metastatic disease to central (CNS) occurs much more frequently, with 10 times that tumors. It is between 20% 40% patients systemic cancer develop metastases. For most recent...
The single-copy gene encoding the alpha subunit of glycoprotein hormones is expressed in pituitaries all mammals and placentas only primates horses. We have systematically analyzed promoter-regulatory elements human bovine alpha-subunit genes to elucidate molecular mechanisms underlying their divergent patterns tissue-specific expression. This analysis entailed use transient expression assays a chorionic gonadotropin-secreting choriocarcinoma cell line, protein-DNA binding assays, chimeric...
In order for boron neutron capture therapy (BNCT) to be successful, a large number (∼109) of 10B atoms must delivered each cancer cell in sustain lethal 10B(n, α)7Li reaction. The majority high grade gliomas express an amplified epidermal growth factor receptor (EGFR) gene, and increased numbers EGFR are found on the surface. If sufficiently could attached EGF, resulting bioconjugates might useful targeting brain tumors. accomplish this, we have boronated fourth-generation starburst...
Abstract Purpose: The purpose of the present study was to evaluate anti–epidermal growth factor monoclonal antibody (mAb) cetuximab (IMC-C225) as a delivery agent for boron neutron capture therapy (BNCT) human epidermal receptor (EGFR) gene-transfected rat glioma, designated F98EGFR. Experimental Design: A heavily boronated polyamidoamine dendrimer chemically linked by means heterobifunctional reagents N-succinimidyl 3-(2-pyridyldithio)-propionate and N-(k-maleimido undecanoic...
Abstract Purpose: The purpose of the present study was to evaluate anti–epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), cetuximab, (IMC-C225) and anti-EGFRvIII mAb, L8A4, used in combination as delivery agents for boron neutron capture therapy (BNCT) a rat glioma composed mixture cells expressing either wild-type (F98EGFR) or mutant receptors(F98npEGFRvIII). Experimental Design: A heavily boronated polyamidoamine dendrimer (BD) linked by heterobifunctional reagents produce...
A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to immunosuppressive microenvironment that promotes tumor growth metastasis. Tasquinimod a novel antitumor agent currently at an advanced stage clinical development treatment castration-resistant prostate cancer. target tasquinimod inflammatory protein S100A9, has been...
Glioblastoma (GBM) is the most common central nervous system malignancy in adults. Despite decades of developments surgical management, radiation treatment, chemotherapy, and tumor treating field therapy, GBM remains an ultimately fatal disease. There currently no definitive standard care for patients with recurrent glioblastoma (rGBM) following failure initial management.
Background and Objective: A versatile biomarker, survivin, is highly expressed in proliferating cells of multiple cancers humans animals. It an apoptosis-regulating protein, engaging a cascade reactions that involve several other genes protein interactions. Currently, researchers are investigating its therapeutic potential due to the evidence linking overexpression advanced-stage lung cancer. This review centered around examining survivin-related molecular mechanisms role specifically Our...
Object. In this study the authors describe secular trends in incidence of three glial tumors—glioblastoma multiforme (GBM), astrocytoma not otherwise specified (ANOS), and anaplastic (AA)—in New York state from 1976 through 1995. They also effect age sex on relative risk (RR) for these tumors, specifically GBM. Methods. Crude, age-, sex-specific rates were calculated each tumor type to 1995 by using data State Cancer Registry. Age-adjusted direct standardization procedure, which 1970 United...
Abstract Purpose: The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron neutron capture therapy (BNCT) receptor-positive rat glioma, F98npEGFRvIII. Experimental Design: A heavily polyamido amine (PAMAM) dendrimer (BD) chemically linked L8A4 by two heterobifunctional reagents, N-succinimidyl 3-(2-pyridyldithio)propionate and N-(k-maleimidoundecanoic acid)hydrazide. For in vivo studies, F98 wild-type receptor-negative or EGFRvIII...
A RETROSPECTIVE STUDY of subdural empyema and epidural abscess spanning 11 years encompassing 41 patients was performed, demonstrating that the clinical characteristics intracranial suppuration have changed over time. Sinusitis otitis media, previously predominant etiologies, were predisposing factors in only 29% patients. prior craniotomy had been performed 66% cases most common risk factor for development. The postoperative subjected to detailed analysis. Patients who undergone a notable...
// Phillip M. Galbo Jr 1 , Michael J. Ciesielski 1, 5, 6 Sheila Figel Orla Maguire 2 Jingxin Qiu 3 Laura Wiltsie 4, Hans Minderman and Robert A. Fenstermaker Department of Neurosurgery, Roswell Park Cancer Institute, Buffalo, New York, 14263 USA Flow Image Cytometry, Pathology, 4 Pediatrics, 5 Center for Immunotherapy, Jacobs School Medicine Biomedical Sciences, State University 14214 Correspondence to: Fenstermaker, email: robert.fenstermaker@roswellpark.org Keywords: exosome; glial...
The single-copy gene encoding the alpha subunit of glycoprotein hormones is expressed in pituitaries all mammals and placentas only primates horses. We have systematically analyzed promoter-regulatory elements human bovine alpha-subunit genes to elucidate molecular mechanisms underlying their divergent patterns tissue-specific expression. This analysis entailed use transient expression assays a chorionic gonadotropin-secreting choriocarcinoma cell line, protein-DNA binding assays, chimeric...