A5038655872- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Social Policy and Reform Studies
- Electoral Systems and Political Participation
- Management of metastatic bone disease
- Boron Compounds in Chemistry
- Public Policy and Administration Research
- Meningioma and schwannoma management
- Policy Transfer and Learning
- Nuclear Physics and Applications
- European Union Policy and Governance
- Political Influence and Corporate Strategies
- Lung Cancer Research Studies
- Political and Economic history of UK and US
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Corporate Identity and Reputation
- Lymphoma Diagnosis and Treatment
- Pharmaceutical industry and healthcare
- Lung Cancer Diagnosis and Treatment
- Disaster Management and Resilience
Reichman University
2024
Hebrew University of Jerusalem
2013-2023
The University of Texas MD Anderson Cancer Center
2005-2022
Radiation Oncology Associates
2014
Fox Chase Cancer Center
2006-2012
RTOG Foundation
1985-2012
Hershey (United States)
2012
University of Houston
1985-2007
Sidney Kimmel Cancer Center
2006
Moffitt Cancer Center
2006
Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients locally advanced laryngeal cancer. The value of adding and optimal timing are unknown.
Purpose To report the long-term results of Intergroup Radiation Therapy Oncology Group 91-11 study evaluating contribution chemotherapy added to radiation therapy (RT) for larynx preservation. Patients and Methods with stage III or IV glottic supraglottic squamous cell cancer were randomly assigned induction cisplatin/fluorouracil (PF) followed by RT (control arm), concomitant cisplatin/RT, alone. The composite end point laryngectomy-free survival (LFS) was primary point. Results Five...
PURPOSE: To describe both the common and less frequently encountered magnetic resonance (MR) imaging features of radiation therapy– chemotherapy-induced brain injury, with particular emphasis on necrosis. MATERIALS AND METHODS: A cohort 148 adult patients underwent surgical resection malignant (glial) tumors were subsequently entered into a research protocol that consisted accelerated therapy carboplatin followed by chemotherapy procarbazine, lomustine, vincristine. Patients typically...
<h3>Objective</h3> To evaluate the incidence of morbidity, mortality, and disease control for patients requiring salvage total laryngectomy (TL) following organ preservation therapy. <h3>Design</h3> Patients entered into a 3-arm randomized prospective multi-institutional trial laryngeal who required TL initial treatment. <h3>Setting</h3> The Radiation Therapy Oncology Group 91-11 preservation. <h3>Patients</h3> From 1992 to 2000, 517 evaluable were receive chemotherapy followed by radiation...
Object. The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I/II study stereotactic body radiotherapy (SBRT) for spinal metastatic tumors. Methods. Sixty-three cancer patients underwent near-simultaneous computed tomography–guided SBRT. Spinal magnetic resonance imaging was conducted at baseline each follow-up visit. National Cancer Institute Common Toxicity Criteria 2.0 assessments were used to evaluate toxicity. Results. median tumor...
Primary and metastatic tumors of the central nervous system are a heterogeneous group neoplasms with varied outcomes management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy radiation as new standard for treating patients pure or mixed anaplastic oligodendroglioma harboring 1p/19q codeletion. For disease, increasing evidence supports efficacy stereotactic radiosurgery multiple lesions but low overall tumor volume. These...
YKL-40 is a secreted protein that has been reported to be overexpressed in epithelial cancers and gliomas, although its function unknown. Previous data smaller sample set suggested was marker associated with poorer clinical outcome genetically defined subgroup of glioblastoma. Here we test these findings larger series patients glioblastoma, particular, determine if tumor expression radiation response.Patients (n=147) subtotal resections were studied for imaging-assessed changes size serial...
Thirty-four patients with stages IE and IIE gastric lymphoma were treated chemotherapy radiotherapy combinations without stomach resection. In 20 patients, the diagnosis was established by endoscopic biopsy only; other 14 had laparotomy biopsy. No patient a gastrectomy before treatment. Nineteen stage disease 15 IIE. Lymphoma diagnoses were: diffuse large-cell, 26; immunoblastic, three; well-differentiated, nodular mixed, one; unclassified, one. The treatment plan to deliver an initial four...
In order to assess the effects of various cancer treatments on neuropsychological functioning, 74 long-term survivors childhood were examined. A comprehensive battery tests was administered two CNS treatment groups (irradiated and nonirradiated leukemia lymphoma patients) a control group (solid tumor Hodgkin disease patients receiving no treatment). The CNS-irradiated obtained lower scores than other groups, with significant differences in visual-motor fine motor skills, spatial memory,...
5517 Background: The 2-year results of Intergroup RTOG 91–11 were published in 2003 (NEJM 349:2091–8,2003). We now present the 5-year (after median follow-up for surviving patients 6.9 years) 515 eligible pts with resectable stage III or IV (excluding T1 and high volume T4), cancer glottic supraglottic larynx. Methods: Patients randomized to induction cisplatin/5-FU (CF) responders then receiving RT (I+RT) (n = 173); concurrent cisplatin (100 mg/m 2 q 21 days × 3) (CRT) 171); alone (R) 171)....
To what extent and how do agencies manage their reputations through the strategic use of communication? Under conditions are regulators inclined to respond external judgments performance, when they disposed keep silent? Based on a comprehensive data set quantitative content analysis Israeli banking regulator's responses public expressions opinion between 1998 mid-2009, we show this agency tends silent issues regarding which it generally enjoys strong reputation, that lie outside its distinct...
OBJECTIVE Whether to administer or omit adjuvant whole-brain radiation therapy in conjunction with stereotactic radiosurgery (SRS) the initial management of patients one three newly diagnosed brain metastases is subject debate. This report provides data from a pilot study which neurocognitive function (NCF) was prospectively measured for treated SRS alone. METHODS Fifteen were Assessment NCF and magnetic resonance imaging scans performed. RESULTS At baseline, 67% had impairment on more tests...
How does the content of public allegations impact regulatory communication strategies? Employing a multinomial logistic regression analysis and an original data set, this article analyzes Israeli banking regulator's nuanced responses to expressions opinion between 1996 2012. We demonstrate agency's greater propensity acknowledge problems, yet mostly shift blame others when faced with claims that regulation is overly lenient, deny excessive. These findings, although based on one institution,...
In 2010, an estimated 22,020 new cases of primary brain and other nervous system neoplasms were diagnosed in the United States, 1 approximately 13,140 deaths occurred from these tumors.The incidence malignant tumors has been increasing over past 30 years, especially elderly persons. 2 Metastatic disease to central (CNS) occurs much more frequently, with 10 times that tumors.Between 20% 40% patients systemic cancer will develop metastases.