A5031915406- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- AI in cancer detection
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Carcinogens and Genotoxicity Assessment
- Acute Myeloid Leukemia Research
- Air Quality and Health Impacts
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cervical Cancer and HPV Research
- Nutrition, Genetics, and Disease
- Cancer survivorship and care
- Cancer, Lipids, and Metabolism
- Survey Methodology and Nonresponse
- Patient-Provider Communication in Healthcare
- Male Breast Health Studies
- COVID-19 and healthcare impacts
University of Illinois Chicago
2016-2025
University of Vermont
2016-2025
Kaiser Permanente Washington Health Research Institute
2016-2025
University of Washington
2016-2025
Dartmouth College
2025
Fred Hutch Cancer Center
2025
University of California, Davis
2017-2025
Dartmouth Institute for Health Policy and Clinical Practice
2018-2025
Huntsman Cancer Institute
2025
Illinois Department of Public Health
2012-2024
Purpose To establish performance benchmarks for modern screening digital mammography and assess trends over time in U.S. community practice. Materials Methods This HIPAA-compliant, institutional review board–approved study measured the of interpreted by 359 radiologists across 95 facilities six Breast Cancer Surveillance Consortium (BCSC) registries. The included 1 682 504 mammograms performed between 2007 2013 792 808 women. Performance measures were calculated according to American College...
Objectives. A community trial was undertaken to evaluate the effectiveness of North Carolina Breast Cancer Screening Program, a lay health advisor network intervention intended increase screening among rural African American women 50 years and older. Methods. stratified random sample 801 completed baseline (1993–1994) follow-up (1996–1997) surveys. The primary outcome self-reported mammography use in previous 2 years. Results. associated with an overall 6 percentage point (95% confidence...
BACKGROUND The role of adjuvant chemotherapy in patients with stage II colon cancer remains to be elucidated and its use varies between institutions. Currently, clinical guidelines suggest discussing for high‐risk disease the absence conclusive randomized controlled trial data. To further investigate this relationship, objective current study was determine whether an association exists overall survival (OS) stratified by age pathological risk features. METHODS Data from National Cancer Base...
Background: Black and Hispanic women are diagnosed at a later stage of breast cancer than white women. Differential access to specialists, diffusion technology, affiliation with an academic medical center may be related this disparity. Methods: We analyzed data from mammography facility survey for the metropolitan region Chicago, Illinois, assess in part whether quality imaging services were equally accessed by non-Hispanic white, black, without private insurance. Of 49 screening facilities...
Digital mammography (DM) and digital breast tomosynthesis (DBT) are used for routine cancer screening. There is minimal evidence on performance outcomes by age, screening round, density in community practice.To compare DM vs DBT baseline subsequent category.This comparative effectiveness study assessed 1 584 079 examinations of women aged 40 to 79 years without prior history cancer, mastectomy, or augmentation undergoing at 46 participating Breast Cancer Surveillance Consortium facilities...
Purpose To establish contemporary performance benchmarks for diagnostic digital mammography with use of recent data from the Breast Cancer Surveillance Consortium (BCSC). Materials and Methods Institutional review board approval was obtained active or passive consenting processes to obtain a waiver consent enroll participants, link data, perform analyses. Data were six BCSC registries (418 radiologists, 92 radiology facilities). Mammogram indication assessments prospectively collected women...
Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations and biological significance cancer-associated epigenetic need further elucidation. Pyrosequencing was done on bisulfite-treated from formalin-fixed, paraffin-embedded sections containing invasive tumor paired samples histologically normal tissue adjacent to cancers as well control reduction mammoplasty unaffected women. The regions studied were promoters (BRCA1, CD44, ESR1,...
Whole-breast ultrasonography has been advocated to supplement screening mammography improve outcomes in women with dense breasts.To determine the performance of plus compared alone community practice.Observational cohort study. Two Breast Cancer Surveillance Consortium registries provided prospectively collected data on vs without same-day breast from January 1, 2000, December 31, 2013. The dates analysis were March 2014 2018. A total 6081 examinations 3386 propensity score matched 1:5 30...
To evaluate comparative associations of breast magnetic resonance imaging (MRI) background parenchymal enhancement (BPE) and mammographic density with subsequent cancer risk.
The coronavirus disease 2019 (COVID-19) pandemic led to a near-total cessation of mammography services in the United States mid-March 2020. It is unclear if screening and diagnostic volumes have recovered prepandemic levels whether use has varied by women's characteristics.We collected data on 461 083 mammograms 112 207 conducted during January through July 2020 at 62 radiology facilities Breast Cancer Surveillance Consortium. We compared monthly before stratified age, race ethnicity, breast...
Diagnostic delays in breast cancer detection may be associated with later-stage disease and higher anxiety, but data on multilevel factors diagnostic delay are limited.To evaluate individual-, neighborhood-, health care-level differences time from abnormal screening to biopsy among racial ethnic groups.This prospective cohort study used women aged 40 79 years who had results mammograms conducted 109 imaging facilities across 6 US states between 2009 2019. Data were analyzed February 21...
Black women with hormone receptor-positive breast cancer experience the greatest racial disparity in survival of all subtypes. The relative contributions social determinants health and tumor biology to this are uncertain.
Despite similar on-site availability, differences existed in the distribution of some standard-of-care, advanced, and same-day diagnostic services biopsies for Black White patients after undergoing screening mammography.
Psychological stress can contribute to health disparities in populations that are confronted with the recurring of everyday life. A number biomarkers have been shown be affected by psychological stress. These include allostatic load, which is a summary measure cumulative biological burden repeated attempts adapt daily Allostatic load includes effects on hypothalamic-pituitary axis, sympathetic nervous system and cardiovascular system. turn affect immune via bidirectional signaling pathways....
Abstract Background: Despite current recommendations for women to be screened breast cancer with mammography every 1 2 years, less than half of all newly diagnosed cancers are initially detected through screening mammography. Prompt medical attention a new symptom can result in earlier stage at diagnosis, yet many patients delay seeking care after becoming aware symptom. Methods: In population-based study cancer, we examined factors potentially associated patient health among 436 symptomatic...
Racial/ethnic disparities exist along the breast cancer continuum, including time to a diagnosis. Previous research has largely focused on patient-level factors, and less is known about role that health care facilities may play in delayed care.We examined racial/ethnic diagnosis for Breast Cancer Care Chicago Study estimated potential mediating effects of facility factors.Breast patients (N=606) contributed interview medical record data as part population-based study.Race/ethnicity was...
Purpose To compare screening magnetic resonance (MR) imaging performance in the Breast Cancer Surveillance Consortium (BCSC) with Imaging Reporting and Data System (BI-RADS) benchmarks. Materials Methods This study was approved by institutional review board compliant HIPAA included BCSC MR examinations collected between 2005 2013 from 5343 women (8387 examinations) linked to regional Surveillance, Epidemiology, End Results program registries, state tumor pathologic information databases that...
Abstract Background: Overweight/obesity and dense breasts are strong breast cancer risk factors whose prevalences vary by race/ethnicity. The population attributable proportions (PARP) explained these across racial/ethnic groups unknown. Methods: We analyzed data collected from 3,786,802 mammography examinations (1,071,653 women) in the Breast Cancer Surveillance Consortium, associated with 21,253 invasive cancers during a median of 5.2 years follow-up. HRs for body mass index (BMI) density,...
Abstract Background Estimating advanced breast cancer risk in women undergoing annual or biennial mammography could identify who may benefit from less more intensive screening. We developed an actionable model to predict cumulative 6-year (prognostic pathologic stage II higher) according screening interval. Methods included 931 186 aged 40-74 years the Breast Cancer Surveillance Consortium 2 542 382 (prior mammogram within 11-18 months) 752 049 19-30 mammograms. The prediction includes age,...
We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer an ethnically diverse group of patients the Breast Cancer Care Chicago (BCCC) study and using data from The Genome Atlas (TCGA). was extracted formalin-fixed, paraffin-embedded samples on 75 (21 White, 31 African-American, 23 Hispanic) (training dataset) enrolled BCCC. Hormone receptor status defined as negative if tumors for both estrogen progesterone (ER/PR)...