A5084489929- Optical Imaging and Spectroscopy Techniques
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Infrared Thermography in Medicine
- Cell Adhesion Molecules Research
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Non-Invasive Vital Sign Monitoring
- Male Breast Health Studies
- Periodontal Regeneration and Treatments
- Metastasis and carcinoma case studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Body Contouring and Surgery
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Screening and Detection
- Body Composition Measurement Techniques
Dartmouth College
2012-2025
Dartmouth–Hitchcock Medical Center
2015-2025
Huntsman Cancer Institute
2025
University of Vermont
2025
Kaiser Permanente Washington Health Research Institute
2025
Fred Hutch Cancer Center
2025
University of California, Davis
2025
Dartmouth Institute for Health Policy and Clinical Practice
2025
University of Washington
2025
University of Illinois Chicago
2025
Breast cancer screening examinations using digital breast tomosynthesis (DBT) has been shown to be associated with decreased false-positive test results and increased detection compared mammography (DM). Little is known regarding the size stage of types detected their association age density.To determine whether DBT detect cancers that are an improved prognosis compare rates by patient density.This retrospective analysis prospective cohort data from 3 research centers in Population-based...
The response of human endothelial cell migration to various extracellular matrix components and growth factors has been assessed. Human cells demonstrate increased chemotaxis chemokinesis when placed in a modified Boyden chamber with factor (ECGF) used at concentration 10(-9) M. Anti-ECGF antibody inhibits the chemotactic response. Heparin (10(-8) 10(-10) M) was also shown potentiate activity ECGF. Although laminin, fibronectin, polypeptide (epidermal, fibroblast, nerve) factors, collagen...
One objective of periodontal therapy after resolution the infectious process is to facilitate a new connective tissue attachment root dentin surface. Here we report that selective advantage for and growth can be conferred on human gingival fibroblasts by biochemical manipulation Tetracycline HCL treatment surface increases binding fibronectin. The adsorbed fibronectin stimulates fibroblast growth, while suppressing epithelial cell growth. This may provide useful approach periodontally involved teeth.
Selective use of tetracycline HCl was studied to evaluate a potential treatment methodology. Tetracycline adsorbed dentin surfaces, binding 4.7 μg/mm 2 after 5 min exposure 50 mg/ml solution. Desorption in discontinuous flow assay maintained biologically active concentrations the fluid phase for at least 48 h. The bound, and subsequently released from retained antimicrobial activity with an ID 3.7 μg/ml. conditioning removed amorphous surface layer, thereby exposing open tubules, as...
Despite similar on-site availability, differences existed in the distribution of some standard-of-care, advanced, and same-day diagnostic services biopsies for Black White patients after undergoing screening mammography.
Abstract Purpose: To determine whether pretreatment biomarkers obtained from diffuse optical spectroscopic tomographic (DOST) imaging predicts breast tumor response to neoadjuvant chemotherapy (NAC), which would have value potentially eliminate delays in prescribing definitive local regional therapy that may occur a standard complete 6- 8-month course of NAC. Experimental Design: Nineteen patients undergoing NAC were imaged with DOST before, during, and after treatment. The images total...
Background Prior cross-sectional studies have observed that breast cancer screening with digital tomosynthesis (DBT) has a lower recall rate and higher detection compared mammography (DM). Purpose To evaluate outcomes DBT versus DM on successive rounds. Materials Methods In this retrospective cohort study, data from 58 imaging facilities in the Breast Cancer Surveillance Consortium were collected. Analysis included women aged 40-79 years undergoing or 2011 to 2020. Absolute differences by...
Polymorphonuclear neutrophils (PMN) traverse basement membrane to reach sites of infection. We have studied the role laminin, a specific component, in this process using three assay systems. In Boyden chamber, laminin was found stimulate chemotaxis while fibronectin did not. Co-incubation cells with antibody blocked chemotaxis, without effect. human amnion system, were shown penetrate through tissue when peptide chemoattractant f-Met-Leu-Phe placed on opposing side. Antibody but not...
A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal malignant breast tissues.FD acquisitions were confined wavelengths less than 850 nm because of detector limitations, whereas light from longer (up 948 nm) measured in CW mode with CCD-coupled spectrometer detection. The two data sets combined processed a single spectrally constrained reconstruction map concentrations hemoglobin, water, lipid, as well scattering...
Digital breast tomosynthesis (DBT) has reduced recall and increased cancer detection compared with digital mammography (DM), depending on women's age density. Whether DBT screening access use are equitable across groups of women based race/ethnicity socioeconomic characteristics is uncertain.To determine to race/ethnicity, educational attainment, income.This cross-sectional study included 92 geographically diverse imaging facilities 5 US states, at which a total 2 313 118 examinations were...
Background It is important to establish screening mammography performance benchmarks for quality improvement efforts. Purpose To digital breast tomosynthesis (DBT) and evaluate trends over time in U.S. community practice. Materials Methods In this retrospective study, DBT examinations were collected from five Breast Cancer Surveillance Consortium (BCSC) registries between 2011 2018. Performance measures included abnormal interpretation rate (AIR), cancer detection (CDR), sensitivity,...
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as the most common chronic disease, is soon to be leading indication for transplantation; however, diagnosis may remain occult decades. There a need biomarkers that identify patients at risk MASLD and progression optimize patient management outcomes. Lymph node adiposity (LNA) novel marker of identified within axillary lymph nodes on screening mammography. Recent studies have demonstrated...
The chaotic vascular network surrounding malignant tumors leads to pulsatile blood flow patterns that differ from those in benign regions of the breast. This study aimed determine if high-speed electrical impedance tomography (EIT) is able detect conductivity changes associated with cyclic blood-volume and gauge potential using these signatures differentiate within EIT imaging pulsating latex membranes submerged saline baths provided initial validation its use for tracking temporally varying...
Introduction: Tumor hypoxia confers both a poor prognosis and increased resistance to oncologic therapies, therefore modification during anti-cancer treatment is desirable. The OxyChip an implantable oxygen sensor that can detect tumor levels using electron paramagnetic resonance (EPR) oximetry. We report initial safety feasibility outcomes after implantation in first-in-humans clinical trial (NCT02706197, www.clinicaltrials.gov). Materials Methods: Twenty-four patients were enrolled....
Objective The overall objective of this clinical study was to validate an implantable oxygen sensor, called the ‘OxyChip’, as a clinically feasible technology that would allow individualized tumor-oxygen assessments in cancer patients prior and during hypoxia-modification interventions such hyperoxygen breathing. Methods Patients with any solid tumor at ≤3-cm depth from skin-surface scheduled undergo surgical resection (with or without neoadjuvant therapy) were considered eligible for study....
Using screening mammography, this study investigated the association between obesity and axillary lymph node (LN) size morphology.We conducted a retrospective review of 188 females who underwent mammography at an academic medical centre. Length width LN hilum were measured in largest, mammographically visible node. The hilo-cortical ratio (HCR) was calculated as hilar divided by cortical width. Measurements performed board certified breast radiologist resident radiology physician....