A5030382731- Digital Radiography and Breast Imaging
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- AI in cancer detection
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Autophagy in Disease and Therapy
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Acute Lymphoblastic Leukemia research
- Acute Kidney Injury Research
- MRI in cancer diagnosis
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and related disorders
- Ubiquitin and proteasome pathways
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
First Affiliated Hospital of Zhengzhou University
2018-2025
Northwest University
2025
Xuzhou Medical College
2025
University of California, San Diego
2024
Nanjing University of Chinese Medicine
2019-2024
Jiangsu Province Hospital
2019-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Kaiser Permanente Washington Health Research Institute
2012-2023
Yuhuangding Hospital
2018-2023
Regulatory CD4(+)CD25(Hi) T cells (Treg) and programmed death-1 (PD-1) molecule have emerged as pivotal players in immune regulation. However, the underlying mechanisms by which they impact antigen-specific CD8(+) responses cancer patients how interact with each other under physiologic conditions remain unclear. Herein, we examined relationship of PD-1 its abrogation to function Treg melanoma using short-term vitro assays generate melanoma-specific cells. We identified circulation vaccinated...
Twenty-one states have laws requiring that women be notified if they dense breasts and advised to discuss supplemental imaging with their provider.To better direct discussions of by determining which combinations breast cancer risk Breast Imaging Reporting Data System (BI-RADS) density categories are associated high interval rates.Prospective cohort.Breast Cancer Surveillance Consortium (BCSC) facilities.365,426 aged 40 74 years who had 831,455 digital screening mammography...
The AKT/PKB kinase is a key signaling component of one the most frequently activated pathways in cancer and major target drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH (PI3K) or loss Phosphatase Tensin homolog (PTEN). We uncovered that growth factors binding to RTKs lead non-receptor tyrosine kinase, Ack1 (also known as ACK TNK2), which directly phosphorylates AKT at an evolutionarily conserved 176 domain....
<h3>Importance</h3> Broad-based genomic sequencing is being used more frequently for patients with advanced non–small cell lung cancer (NSCLC). However, little known about the association between broad-based and treatment selection or survival among NSCLC in a community oncology setting. <h3>Objective</h3> To compare clinical outcomes who received vs control group of routine testing for<i>EGFR</i>mutations and/or<i>ALK</i>rearrangements alone. <h3>Design, Setting, Participants</h3>...
<h3>Importance</h3> Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed widespread implementation, particularly in rural and underserved populations lacking ready access to treatment. <h3>Objective</h3> To evaluate the effectiveness telephone CBT-I vs education-only control (EOC) older adults with moderate severe osteoarthritis pain. <h3>Design, Setting, Participants</h3> This is a randomized clinical trial 327 participants 60...
Abstract BACKGROUND Androgen receptor (AR) plays a critical role in the progression of both androgen‐dependent and androgen‐independent prostate cancer (AIPC). Ligand‐independent activation AR AIPC or castration resistant (CRPC) is often associated with poor prognosis. Recently, tyrosine kinase Ack1 has been shown to regulate activity by phosphorylating it at 267 this event was be for growth. However, whether small molecule inhibitor that can mitigate sufficient abrogate on regulated...
Pancreatic cancer is a significant cause of mortality worldwide as the disease has advanced significantly in patients before symptoms are evident. The signal transduction pathways that promote this rapid progression not well understood. Ack1 or TNK2, an ubiquitously expressed oncogenic non–receptor tyrosine kinase, integrates signals from ligand-activated receptor kinases to modulate intracellular signaling cascades. In present study, we investigated activation profile pancreatic tumor...
Abelmoschus manihot (L.) Medik. (Malvaceae) is a herb used in traditional Chinese medicine to treat some kidney diseases. To date, the detailed mechanisms by which A. improves kinds of renal disease are not fully understood. In this study, we established Adriamycin-induced NRK-52E cells, normal rat epithelial cell line, injury, and Sprague-Dawley rats with nephropathy evaluate role total extracts flower (TEA) both vitro vivo. We found that TEA ameliorated cellular morphological changes,...
Digital breast tomosynthesis (DBT) has reduced recall and increased cancer detection compared with digital mammography (DM), depending on women's age density. Whether DBT screening access use are equitable across groups of women based race/ethnicity socioeconomic characteristics is uncertain.To determine to race/ethnicity, educational attainment, income.This cross-sectional study included 92 geographically diverse imaging facilities 5 US states, at which a total 2 313 118 examinations were...
Breast density is associated with breast cancer risk in women aged 40 to 65 years, but there limited evidence of its association among years or older.To compare the between and invasive 74 vs 75 older evaluate whether modified by body mass index (BMI).This prospective cohort study used data from Cancer Surveillance Consortium January 1, 1996, December 31, 2012, for US who underwent screening mammography. Data were analyzed 2018, 2020.Breast Imaging Reporting System category, age, BMI.The...
Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy with high incidence rate and poor prognosis. Enolase-1 (ENO1), a key glycolytic enzyme, has been implicated in the tumorigenesis of various cancers. However, its diagnostic value clinical significance HCC are unclear. Methods: Data 374 tissues 50 nontumor were retrieved from The Cancer Genome Atlas database, expression level ENO1 mRNA was evaluated. In addition, meta-analysis 12 cohorts deposited Gene Expression Omnibus...
This study aims to investigate the correlation between dietary inflammatory index (DII) and mortality resulting from all-cause cardiovascular diseases (CVD) in adults affected by metabolic syndrome (MetS). The focus of this was analyze information 13,751 who had been diagnosed with MetS. DII scores were computed based on a 24-hour intake at start study. By implementing both Cox regression analysis restricted cubic spline(RCS) analysis, we examined score mortality. After mean follow-up...
Abstract Macrophages play important roles in maintaining intestinal homeostasis and the pathogenesis of inflammatory bowel diseases (IBDs). However, underlying mechanisms that govern macrophage-mediated inflammation are still largely unknown. In this study, we report RNF128 is downregulated proinflammatory macrophages. deficiency leads to elevated levels effector cytokines vitro accelerates progression IBD mouse models. Bone marrow transplantation experiments revealed bone cells contributes...
Prostate Tumor Overexpressed 1 (PTOV1) is overexpressed and associated with malignant phenotypes in various types of tumors. However, the detailed roles PTOV1 its underlying mechanism CRC remain unclear. The clinical significance was assessed databases samples. effects on tumor-associated were detected by several vitro assays vivo mouse models. Immunoprecipitation (IP) combined protein mass spectrometry Co-Immunoprecipitation (Co-IP) used to identify p53 interacting PTOV1. Immunofluorescence...
Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role hepatocellular has not been elucidated. We confirmed HOXB4 downregulated tissues and lower expression associated prognosis. Gain- loss-of function experiments were performed to understand the functional consequences. revealed overexpression inhibited proliferation metastasis of cells, accompanied decrease...
Given the heightened focus on high-risk populations, this study aimed to provide insights into early susceptibility and preventive strategies for colorectal cancer (CRC) by focusing populations. In research, fecal samples from 1,647 individuals across three discovery cohorts nine external validation were sequenced using whole-genome metagenomic sequencing. A prediction model based random forest was constructed independently validated with cohorts. disease probability (POD) microbial...
This study evaluated the impact of health system-based outreach and reminders on human papillomavirus (HPV) vaccine series initiation completion. Parents 10 to 12 year olds (n = 1805) were randomized receive either (1) an letter brochure recommending HPV vaccination followed by automated or (2) usual care. We interviewed a subset 50 parents assess program acceptability. Outcomes during period on-time Rates (July 2015 August 2016) similar between intervention control groups, but within 120...
Abstract Background The suicide risk was higher in kidney cancer patients than the general population. purpose of this study to characterize rates among and identify potential factors associated with from Surveillance, Epidemiology, End Results (SEER) database. Methods Kidney were identified SEER database during 1973‐2015. Suicide standardized mortality ratios (SMRs) population calculated, US 1981‐2015 chosen as a reference. Univariable multivariable Cox regression performed find out...