Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular process allows formation three CC bonds in one operation through CH activation/carbopalladation/CH activation sequence.

Direct benzylation of carboxylic acids with toluene has been developed via palladium-catalyzed C-H acyloxylation under 1 atm oxygen. This reaction demonstrates good functional group tolerance and high yields, providing a facile, atom-economic, efficient method for the synthesis benzyl esters.

Lantibiotics are antimicrobial peptides produced by bacteria. Some employed for food preservation, whereas others have therapeutic potential due to their activity against organisms resistant current antibiotics. They ribosomally synthesized and posttranslationally modified dehydration of serine threonine residues followed attack thiols cysteines form monosulfide lanthionine methyllanthionine rings, respectively. Chemical synthesis peptide analogues is a powerful method verify stereochemistry...

Abstract Bacteria and fungi are core microorganisms in diverse ecosystems, their cross‐kingdom interactions considered key determinants of microbiome structure ecosystem functioning. However, how bacterial‐fungal mediate soil organic carbon (SOC) dynamics remains largely unexplored the context artificial forest ecosystems. Here, we characterised bacterial fungal communities four successive planting Eucalyptus compared them to a neighbouring evergreen broadleaf forest. Carbon (C)...

Lactocin S is a lantibiotic peptide with potent antibacterial activity against range of Gram-positive bacteria. Because challenges in obtaining sufficient quantities this compound from natural sources, the stereochemistry lanthionine residues lactocin had not been confirmed. This report describes chemical synthesis on chlorotrityl polystyrene resin 10% overall yield using intramolecular cyclization to form rings and employing fragment coupling for two N-terminal residues. represents first...

Abstract This microreview is divided into four parts: introduction, benzylic monofluorination, difluorination and summary. Each procedure (base‐mediated, transition‐metal‐catalyzed, radical‐initiated fluorination) described for the cases of both electrophilic nucleophilic fluorine sources, with exception difluorination, which only in case literature. Moreover, specifically fluorination, procedures are further classified according to nature radical initiators used.

Porcine epidemic diarrhea (PED) caused by porcine virus (PEDV) is one of the most devastating diseases in global pig industry due to its high mortality rate piglets. Maternal vaccines can effectively enhance gut-mammary gland-secretory IgA axis boost lactogenic immunity and passive protection nursing piglets against PEDV challenge. From 2017 2021, we collected 882 samples from 303 farms China investigate epidemiology PEDV. The result showed that about 52.15% (158/303) were positive for with...

Hepatocellular carcinoma is a fatal malignancy that lacking specific therapies. Homeobox B4 (HOXB4) was negatively correlated with poor prognosis in cancers, but its role hepatocellular has not been elucidated. We confirmed HOXB4 downregulated tissues and lower expression associated prognosis. Gain- loss-of function experiments were performed to understand the functional consequences. revealed overexpression inhibited proliferation metastasis of cells, accompanied decrease...

Nach einem modularen Ansatz wurden tetrasubstituierte helicale Alkene hergestellt. Dabei ermöglicht eine intermolekulare, Pd-katalysierte und Norbornen-vermittelte Dominoreaktion die Bildung dreier C-C-Bindungen in einzigen Arbeitsschritt über Sequenz aus C-H-Aktivierung, Carbopalladierung erneuter C-H-Aktivierung. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...

A highly modular and stereoselective synthesis of tetrasubstituted helical alkenes is accomplished by a Pd-catalyzed norbornene-mediated domino reaction. This protocol features the rapid assembly four C–C bonds via sequential C–H activations carbopalladations along with efficient access to enantiopure bromoalkyl aryl alkyne precursors using homologative alkynylation as key transformation. Three distinct elements stereoselectivity were observed in preparation chiral alkenes: retention...

Abstract Our ongoing effort towards the development of highly selective transition‐metal‐catalysed C–H activation processes has led to expansion Catellani reaction. In a Pd 0 /Pd II IV ‐catalysed domino reaction, an aryl iodide, alkyl iodide and tert ‐butyl acrylate were combined synthesize carbon framework novel lignan (+)‐linoxepin. The enantioselective synthesis highlights work accomplished in our group provides excellent procedure for reliable scalable architecturally complex scaffolds....

// Lili Huang 1 , Ming Shen Rongxin Li Xiangyu Zhang Ying Sun Pei Gao Hao Fu Hongqiang Liu 2 Yang He Yuqing Du 3 Jun Cao Yourong Duan State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School Medicine, Shanghai, China Department Interventional Oncology, Dahua Xuhui District, Radiology, Pudong New District Punan Correspondence to: Duan, email: yrduan@shsci.org Cao, juncao11@sina.com Du, du_yqsh@sina.cn Keywords:...

Abstract Benzothiazole‐doped porous organic polymers ( POP‐MBTS ) were synthesized from a copolymerization reaction of 2‐(6‐(4‐vinylphenyl)pyridin‐2‐yl)benzo[ d ]thiazole with divinylbenzene. The corresponding POP‐MBTS‐Ir was obtained and fully characterized using SEM, TEM, EDS, TGA, XPS, N 2 sorption isotherms, which disclosed that this catalyst has high surface area, hierarchical porosity, thermodynamic stability. Importantly, revealed catalytic activity for ten different kinds borrowing...

An electrochemical cross-dehydrogenative coupling of indoles with xanthenes has been established at room temperature. This reaction could proceed in the absence any catalyst or external oxidant, and generate indole derivatives moderate yields. Mechanistic experiments support that a radical pathway maybe involved this system.

Regio- and stereoselective aziridine ring opening with oxygen nucleophiles derived from serine threonine provides a route to stereochemically pure 4-oxa-2,6-diaminopimelic acid (oxa-DAP) its methyl-substituted derivatives. Oxa-DAP is substrate of DAP epimerase, key enzyme for biosynthesis l-lysine formation peptidoglycan precursors. Orthogonally protected analogues lanthionine β-methyllanthionine wherein replaces sulfur were prepared that could be used solid-supported peptide synthesis make...

Neopetrosiamides A and B (2) from the marine sponge Neopetrosia sp. are two diastereomeric tricyclic peptides that inhibit tumor cell invasion associated with metastasis. The reported structures were chemically synthesized using solid-phase peptide synthesis sequential stepwise disulfide bond formation in solution. connectivity of originally proposed was revised confirmed by chemical together a combination HPLC analysis, mapping, biological activity testing. This methodology also utilized to...

Abstract Background Although DNA vaccine holds a great potential for cancer immunotherapy, effective long-lasting antitumoral immunity sufficient to induce durable responses in patients remains be achieved. Considering the pivotal role of dendritic cells (DC) antigen processing and presentation, we prepared DC-targeting vaccines by fusing tumor-associated HER2/neu ectodomain single chain antibody fragment (scFv) from NLDC-145 specific DC-restricted surface molecule DEC-205 (scFv ), explored...

An oxidatively stable analogue 3 of lacticin 3147 A2 (2), wherein the sulfur atoms are replaced with oxygens, was synthesized using solution phase peptide synthesis and sequential on-resin cyclizations. Biological evaluation suggests that oxa-lacticin (3) retains independent antimicrobial activity against Gram-positive bacteria but lacks synergistic natural A1 is characteristic native peptide.

Abstract A kind of amino‐functionalized ionic liquid has been prepared and investigated as ligand base for the Heck reactions between aryl iodides bromides with olefins in presence a catalytic amount Pd submicron powder [Bmim]PF 6 . The generated corresponding products excellent yields under mild reaction conditions. generality this system to different substrates also gave satisfactory results. key feature is that species liquids were easily recovered reused six times constant activity....

Abstract The copper‐catalyzed decarboxylative methylation of aromatic carboxylic acids was developed by using PhI(OAc) 2 to provide a new strategy for the aryl through decarboxylation alkyl acids. mechanism and roles each reactant in reaction were investigated extensively.