A5057940370- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Sulfur-Based Synthesis Techniques
- Electrocatalysts for Energy Conversion
- Fuel Cells and Related Materials
- Advanced biosensing and bioanalysis techniques
- Synthesis and Reactions of Organic Compounds
- Freezing and Crystallization Processes
- Carbohydrate Chemistry and Synthesis
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Synthesis of heterocyclic compounds
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Advanced Memory and Neural Computing
Nanyang Technological University
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2002-2024
Xi'an Jiaotong University
2024
South China University of Technology
2023-2024
Yantai University
2019-2024
Harbin Engineering University
2023
University of Hawaii at Hilo
2013-2016
Shanghai Institute of Organic Chemistry
2011-2013
Chinese Academy of Sciences
2011-2012
Xinjiang Petroleum Society
2006
To further our understanding on the antibacterial activity of single-walled carbon nanotubes (SWCNTs), high purity SWCNTs with average diameter 0.83 nm and (7,5) chirality as dominate (n,m) structure were dispersed in a biocompatible surfactant solution. Ultraviolet−visible−near-infrared radiation absorption spectroscopy was employed to monitor aggregation SWCNTs. The results demonstrated that individually more toxic than SWCNT aggregates toward bacteria (gram-negative Escherichia coli,...
The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.
Abstract A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This features the first NHC‐catalyzed addition of to acetylenic acylazolium intermediates eventually set up C−N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups are feasible for further transformations.
A carbene-catalyzed reductive coupling reaction of carboxylic esters and substituted Hantzsch is disclosed. Key steps this include one-electron reduction a carbene catalyst-bound acyl azolium intermediate to generate the corresponding radical for subsequent alkylation reactions. The promoted by irradiation with visible light without involvement transition-metal photocatalysts. Mechanistic studies suggest that direct photoexcitation in situ formed likely responsible light-induced...
A simple, rapid and convenient SERS-based competitive lateral flow assay was developed for highly sensitive detection of PCA3 mimic DNA.
Three stereogenic centers in a row: The unconventional activation of enal compounds mediated by an N-heterocyclic carbene (NHC) has generated three consecutive reactive carbon that undergo highly regio- and stereoselective annulations with di(enone)s to generate benzotricyclic products containing multiple (see scheme). Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions such transformations are attractive but challenging. A direct catalytic activation simple N-heterocyclic carbene organocatalysts to generate enolate intermediates for highly enantioselective reactions reported.
An NHC-catalyzed activation of acetic esters to afford enolate intermediates is disclosed. The catalytically generated triazolium serve as two-carbon nucleophiles that undergo highly enantioselective reactions with enones and α,β-unsaturated imines give α-unsubstituted δ-lactones lactams, respectively.
Abstract A carbene‐catalyzed intermolecular C−N bond formation, which initiates a highly selective cascade reaction for the synthesis of pyrrolidine fused β‐lactones, is disclosed. The nitrogen‐containing bicyclic β‐lactone products are obtained with good yields and excellent stereoselectivities. Synthetic transformations into useful functional molecules, such as amino catalysts, can be efficiently realized under mild conditions. Mechanistically, this study provides insights modulating...
To facilitate the extensive adoption of proton exchange membrane fuel cells (PEMFCs), it is important to address issues electrochemical corrosion and weak interaction with platinum (Pt) caused by carbon support. Herein, a strong metal–support (SMSI) effect was constructed Pt nanoparticles loaded in porous chromium nitride (CrN) nanogrids (labeled as Pt/CrN). The CrN are synthesized via Maillard nitridation method, better support size obtained controlling average diameter adjusting proportion...
Two trifluoromethyl-substituted building blocks β-(trifluoromethyl)vinyl sulfonium salts 1 and 2 were developed. Reactions of salt with active methylene compounds containing electron-withdrawing groups using DBU as the base in DMSO occurred to give cyclopropane derivatives 7 major products. In contrast, reactions migration one products 8 when NaH was used DMSO. Moreover, THF/CH(2)Cl(2) at -78 °C, reaction gave 2,3-dihydrofuran 9 A working mechanism proposed explain different behaviors or...
Uneven ionomer coverage in the cathode catalyst layer of proton exchange membrane fuel cells (PEMFCs) impedes conduction and oxygen diffusion, particularly at low platinum loadings. Here, a functionalized polymer-scaffold is designed constructed by using hydroxy-pyridine polybenzimidazole (PyOHPBI) with abundant hydrogen-bond sites, thereby proposing synergistic strategy to address challenges optimizing distribution enhancing transport protons gas through layer. By integrating molecular...
Abstract We describe the Suzuki coupling reaction of ( E )‐(β‐trifluoromethyl)vinyldiphenylsulfonium salts with arylboronic acid. The highly efficient and selective provides a useful mild method for synthesis trifluoromethylated alkenes dienes. Subsequent DFT studies showed that oxidative addition transition state vinyl C–S bond is much more favorable (11.7 kcal mol –1 ) than aryl bond.
A highly enantioselective method for quick access to dihydrocoumarins is reported. The reaction involves a cooperative catalytic process with carbene and in situ generated Brønsted acid as the catalysts. α-Chloro aldehyde readily available stable o-hydroxybenzhydryl amine substrates were used generate reactive azolium ester enolate ortho-quinone methide (o-QM) intermediates, respectively, form exceptionally high diastereo- enantioselectivities. products can be easily transformed valuable...
A new mode of carbene-catalyzed heteroatom activation and asymmetric reactions is disclosed. The reaction starts with addition a carbene catalyst to (benz)imidazole-derived aldimine substrate. Subsequent oxidation proton transfer lead the formation catalyst-bound triaza-diene as key intermediate, in which nitrogen atom at site remote catalyst-substrate bond activated. This unusual intermediate then undergoes highly enantioselective activated ketones through concerted asynchronous pathway,...
Abstract A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This features the first NHC‐catalyzed addition of to acetylenic acylazolium intermediates eventually set up C−N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups are feasible for further transformations.
Disclosed here is NHC-catalyzed direct intermolecular trapping of the ketone oxygen atom with acyl azolium intermediate. The overall reaction a dynamic kinetic resolution process that converts to corresponding enol ester well-controlled axial chirality. Our eventually affords non-C2-symmetric binaphthyl derivatives important applications, such as in area asymmetric catalysis.