A visible-light initiated oxidative cyclization of phenyl propiolates with sulfinic acids has been developed at room temperature under metal-free conditions.

The recent advances in photochemical or electrochemical C–F bond activation and functionalization have been summarized discussed.

An electrophilic spirocyclization of N-benzylacrylamides with N-halosuccinimides (NXS) as the halogenating reagents has been developed. This reaction is carried out at room temperature under simple conditions without relying on metal reagents, photochemistry, or electrochemistry, providing a fast and efficient route to synthesize wide variety 4-halomethyl-2-azaspiro[4.5]decanes satisfactory yields. The approach further highlighted through gram-scale synthesis diverse transformations spiro products.

An electrochemical electrophilic bromination/spirocyclization of N -benzyl-acrylamides to brominated 2-azaspiro[4.5]decanes with 2-bromoethan-1-ol as the brominating reagent has been developed.

A visible-light-induced radical relay cyclization/C-C bond formation of quinoxalin-2(1

Azobenzenes were readily acylated at the 2-position through a Pd-catalyzed C-H functionalization from simple aromatic azo compounds and aldehydes in good yields. The obtained azobenzenes could be efficiently converted into corresponding indazole derivatives nearly quantitative

In this paper, indium(III) chloride was found to be a highly effective catalyst for the three-component coupling reactions of aldehydes, alkynes, and amines (A(3)-coupling) via C-H activation. The could applied both aromatic aliphatic aldehydes alkynes. Nearly quantitative yields desired products were obtained in most cases. No cocatalyst or activator is required, water only byproduct reactions. Furthermore, tentative mechanism InCl(3)-catalyzed one-pot, aldehyde, alkyne, amine proposed.

Abstract A highly efficient, air‐ and moisture‐stable easily recoverable magnetic nanoparticle‐supported palladium catalyst has been developed for the Suzuki, Sonogashira Heck reactions. wide range of substrates was coupled successfully under aerobic conditions. In particular, performance separation very it is possible to recover reuse at least eight times without significant loss its catalytic activity.

A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y Pd dual catalytic system. This reaction shows broad substrate scope and good functional group tolerance, an array ortho-acylacetanilides can be afforded in high yields under mild conditions.

A hypervalent iodine(iii) reagent catalyzed carbonylarylation of acrylamides with α-oxocarboxylic acids driven by visible-light without a photoredox catalyst has been developed. The reactions generate the corresponding products in good yields at room temperature. Experiments indicate that blue LED (450-455 nm) is most effective energy for cleavage oxygen-iodine bond to initiate reaction. Mechanistic studies further demonstrate reaction undergoes cascade decarboxylative radical...

Easy access to o-acyl acetanilides: A new Pd-catalyzed ortho-acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a CH activation process. In the presence tert-butyl hydroperoxide (TBHP) as ideal oxidant, this reaction provides an efficient ortho-acyl in good yields (see scheme). Detailed facts importance specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available...

A novel and simple method for the direct amidation of azoles with formamides has been developed. The reaction could occur smoothly in presence tert-butyl perbenzoate (TBPB) as an oxidant under metal- base-free conditions. Direct dehydrogenative cross-coupling generated corresponding products good yields.

A palladium-catalyzed ortho-acylation reaction of azoxybenzenes with α-oxocarboxylic acids was developed in the presence K2S2O8. The established methodology provides a direct approach to obtain acylated good yields.

A novel and efficient Cu-promoted decarboxylative direct C3-acylation of N-substituted indoles with α-oxocarboxylic acids for the synthesis 3-acylindoles was developed.

Benzo[b]furans were prepared in one pot based on the addition/palladium-catalyzed C–H bond functionalization of phenols with bromoalkynes. The addition reactions to bromoalkynes generated (Z)-2-bromovinyl phenyl ethers high yields excellent regio- and stereoselectivity. obtained subsequently proceeded by intramolecular cyclization afford 2-substituted benzo[b]furans good through palladium-catalyzed direct functionalizations. It is important note that transformation into could be carried out...

Avoiding additives: A highly efficient and mild Pd-catalyzed decarboxylative ortho-acylation of azobenzenes with α-oxocarboxylic acids was developed that provides an alternative route to acylated azo compounds. This acylation process completed in the absence any additives at ambient temperature, afford moderate good yields.

An efficient C-H acylation of azo- and azoxybenzenes with α-keto acids has been developed by a combination palladium catalysis visible-light photoredox at room temperature under 1.5 W blue LED irradiation. This method tolerates variety disubstituted azoxybenzenes, as well regardless the nature substituents. A number aryl ketones were obtained in good yields mild reaction conditions.

A novel iron-promoted tandem reaction of anilines with styrene oxides via C–C cleavage and C–H activation has been developed. The utilizes an inexpensive FeCl3 as promoter is suitable for forming a variety 3-arylquinolines from the simple readily available starting materials.

A simple and efficient method for the preparation of α-arylthioethers through a visible-light-induced direct thiolation at α-C(sp3)–H ethers with diaryl disulfides was developed using acridine red as novel photocatalyst. The reactions occurred ambient conditions generated corresponding products in good to excellent yields, ignoring steric effect disulfides.

A simple and efficient protocol for nickel-catalyzed regioselective C–H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope provides a facile useful access to the corresponding C5-functionalized difluoromethylated quinolines in good excellent yields.

A photoinduced oxidative formylation of N,N-dimethylanilines with molecular oxygen in the absence an external photocatalyst was developed and provided corresponding formamides good yields under mild reaction conditions. Investigations indicated that both starting material product act as photosensitizers 1O2 coexists O2•– during through energy transfer single electron process.

A novel and efficient photoinduced synthesis of C6-polyfunctionalized phenanthridines from three-component reactions isocyanides, alkynes sulfinic acids was developed. The generated the corresponding products with high selectivity through photochemical activity formed electron donor–acceptor (EDA) complex during reaction via a radical tandem process under mild conditions.

A thiyl radical catalyzed synthesis of diaryl 1,2-diketones from diarylalkynes by molecular oxygen under visible-light irradiation without a photocatalyst was developed.

A site-selective electrochemical C–H bromination of (hetero)arenes with 2-bromoethan-1-ol by releasing available ethylene oxide and hydrogen through paired electrolysis has been developed.