A5101434926- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Animal Virus Infections Studies
- Rough Sets and Fuzzy Logic
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bacteriophages and microbial interactions
- Geological and Geochemical Analysis
- Business Strategy and Innovation
- Bone Tissue Engineering Materials
- Carbon dioxide utilization in catalysis
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Machine Learning in Bioinformatics
- Physiological and biochemical adaptations
- Planarian Biology and Electrostimulation
- Andrographolide Research and Applications
- Effects and risks of endocrine disrupting chemicals
- vaccines and immunoinformatics approaches
- Innovation and Knowledge Management
Dezhou University
2022-2024
Institute of Biophysics
2024
North China University of Science and Technology
2019-2024
Hebei Agricultural University
2020-2024
Liaoning Normal University
2004-2024
Bioscience (China)
2024
Taiyuan Central Hospital
2024
Northwestern Polytechnical University
2019-2023
East China Normal University
2022-2023
Sichuan University
2007-2023
The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While developing novel drugs and vaccines long, repurposing existing against can yield treatments with known preclinical, pharmacokinetic, pharmacodynamic, toxicity profiles, which rapidly enter clinical trials. In this study, we present network-based drug platform to identify candidates for treatment of COVID-19. At time initial outbreak, knowledge about was lacking, but based on its similarity other viruses,...
Volatile organic compounds (VOCs) in urine are valuable biomarkers for noninvasive disease diagnosis. Herein, a facile coordination-driven modular assembly strategy is used developing library of gas-sensing materials based on porous MXene frameworks (MFs). Taking advantage modules with diverse composition and tunable structure, our MFs-based can provide more choices to satisfy demands. Meanwhile, the laser-induced graphene interdigital electrodes array microchamber laser-engraved...
Postmenopausal osteoporosis (PMOP) is a major public health concern worldwide. The present study aimed to provide evidence assist in the development of specific novel biomarkers for PMOP. Differentially expressed genes (DEGs) were identified between PMOP and normal controls by integrated microarray analyses Gene Expression Omnibus (GEO) database, optimal diagnostic gene with LASSO Boruta algorithms. Classification models, including support vector machine (SVM), decision tree random forests...
Benefiting from the development of network pharmacology, Traditional Chinese Medicine (TCM) shows great potential in modern drug discovery. Recently, more and TCM-related databases have been established for both academic industry research, but they are still insufficient data standardization, integrity, precision. To better accelerate TCM research overcome these shortcomings, we construct a web-based platform, LTM-TCM, which is currently most comprehensive database that includes following...
The COVID-2019 disease caused by the SARS-CoV-2 virus (aka 2019-nCoV) has raised significant health concerns in China and worldwide. While novel drug discovery vaccine studies are long, repurposing old drugs against epidemic can help identify treatments, with known preclinical, pharmacokinetic, pharmacodynamic, toxicity profiles, which rapidly enter Phase 3 or 4 be used directly clinical settings. In this study, we presented a network based platform to potential for treatment of COVID-2019....
Porcine epidemic diarrhea (PED) caused by porcine virus (PEDV) is one of the most devastating diseases in global pig industry due to its high mortality rate piglets. Maternal vaccines can effectively enhance gut-mammary gland-secretory IgA axis boost lactogenic immunity and passive protection nursing piglets against PEDV challenge. From 2017 2021, we collected 882 samples from 303 farms China investigate epidemiology PEDV. The result showed that about 52.15% (158/303) were positive for with...
Abstract Motivation: B-cell epitope is a small area on the surface of an antigen that binds to antibody. Accurately locating epitopes critical importance for vaccine development. Compared with wet-lab methods, computational methods have strong potential efficient and large-scale prediction candidates at much lower cost. However, it still not clear which features are good determinants accurate prediction, leading unsatisfactory performance existing methods. Method results: We propose more...
Introduction Porcine viral diarrhea is a common clinical disease, which results in high mortality and economic losses the pig industry. epidemic virus (PEDV), porcine rotavirus (PoRV), deltacoronavirus (PDCoV) are important viruses herds. The similarities of their symptoms pathological changes make it difficult to distinguish these three clinically. Therefore, there need for highly sensitive specific method simultaneously detect differentiate viruses. Methods A multiplex real-time PCR assay...
Credit risk assessment is an important process in bank financial management. Traditional machine-learning methods cannot solve the problem of data islands and high error rate two-way decisions, which not conducive to banks’ accurate credit users. To this end, paper establishes a federated three-way decision incremental naive Bayes user model (FTwNB) that supports asymmetric encryption, uses learning break down barriers between banks, encryption protect security for processes. At same time,...
Aiming at the problems of dynamic increase in data real life and that naive Bayes (NB) classifier only accepts or rejects sample processing results, resulting a high error rate when dealing with uncertain data, this paper combines three-way decision incremental learning, new (3WD-INB) is proposed. First, NB established, distribution fitting carried out according to minimum residual sum squares (RSS) for continuous so 3WD-INB can process both discrete then carry an learning operation, select...
SUMO post-translational modification of proteins or SUMOylation ensures normal cell function. Disruption dynamics prompts various pathophysiological conditions, including cancer. The burden deSUMOylating the large SUMO-proteome rests on 6 full-length mammalian SUMO-proteases SENP. While multiple SENP isoforms exist, function these remains undefined. We now delineate biological role a novel SENP7 isoform SENP7S in mammary epithelial cells. is predominant transcript human epithelia but...
Breast cancer is an aggressive disease with high morbidity and mortality rates among women globally. Tumor protein D52 (TPD52) oncogene in breast cancer; however, its physiological function remains elusive. This study set out to obtain a deeper understanding of the functions TPD52 pathophysiology by exploring effects on cell proliferation migration.Bioinformatics analysis was performed predict bonding nuclear paraspeckle assembly transcript 1 (NEAT1) miR-218-5p. The NEAT1 miR-218-5p were...
// Feng-Ming Lin 1 , Santosh Kumar 2 Jing Ren Samaneh Karami Shaymaa Bahnassy Yue Li 3 Xiaofeng Zheng 4 Wang and Tasneem Bawa-Khalfe Department of Cardiology, The University Texas MD Anderson Cancer Center, Houston, TX, USA Center for Nuclear Receptors Cell Signaling, Biology Biochemistry, Integrative Pharmacology, Health Science at Bioinformatics Computational Biology, Correspondence to: Bawa-Khalfe, email: Keywords : SUMO, SENP7, HP1α, ncRNA, Rad51C Received March 31, 2016 Accepted April...
Abstract Background Porcine epidemic diarrhea (PED) is a contagious intestinal disease caused by porcine virus (PEDV) characterized vomiting, diarrhea, anorexia, and dehydration, which have huge economic losses around the world. At present, vaccine immunity still most effective method to control spread of PED. In this study, we constructed novel recombinant L. casei-OMP16-PEDVS strain expressing PEDVS protein PEDV OMP16 Brucella abortus strain. To know immunogenicity candidate vaccine, it...
Summary Length of hospital stay (LOS) asthma can be a reflection the disease burden faced by patients, and it is also sensitive to air pollution. This study aims at estimating validating effects pollution readmission on LOS for those who have asthma, considering their history, minimum temperature, threshold pollutants. In addition, sex, age, season were constructed stratification achieve more precise specific results. The results show that no significant PM 2.5 NO 2 observed in any but there...
Abstract Background Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs prompts incurable metastatic disease. Hence, ET-resistant (ET-R) HR+ BCa presents a therapeutic challenge. Previous studies show elevated androgen (AR) that supports ET tamoxifen correlates with metastasis. Yet surprisingly, AR-blocker enzalutamide (Enz) in ET-R present conflicting results....