A5000887404- Estrogen and related hormone effects
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Phytoestrogen effects and research
- Cardiovascular Health and Disease Prevention
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Signaling Pathways in Disease
- Breast Cancer Treatment Studies
- Advanced Glycation End Products research
- Exercise and Physiological Responses
- Prostate Cancer Treatment and Research
- Trace Elements in Health
- Gene expression and cancer classification
- Stress Responses and Cortisol
- Long-Term Effects of COVID-19
- Sirtuins and Resveratrol in Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vitamin D Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Cairo University
2025
University of Illinois Chicago
2015-2024
University of Illinois Urbana-Champaign
2024
Menoufia University
2024
Agricultural Research Center
2023
Ain Shams University
2022
London Rebuilding Society
2022
Assiut University
1995-2018
University of Delaware
2017
Newcastle University
2012
Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations and biological significance cancer-associated epigenetic need further elucidation. Pyrosequencing was done on bisulfite-treated from formalin-fixed, paraffin-embedded sections containing invasive tumor paired samples histologically normal tissue adjacent to cancers as well control reduction mammoplasty unaffected women. The regions studied were promoters (BRCA1, CD44, ESR1,...
The glycocalyx is crucial for normal endothelial function. It also tethers extracellular superoxide dismutase (SOD3), which protects the endothelium against oxidative damage. Proteolytic enzymes [matrix metalloproteinases (MMPs)] are capable of disrupting cell surface proteins, such as syndecans, resulting in derangements glycocalyx. We sought to test role MMPs stress-mediated disruption and examine effect pharmacological inhibition on mitigating this detrimental effect. examined histone...
Hyperinsulinemia is a hallmark of insulin resistance-associated metabolic disorders. Under physiological conditions, maintains balance between nitric oxide (NO) and, the potent vasoconstrictor, endothelin-1 (ET-1). We tested hypothesis that acute hyperinsulinemia will preferentially augment ET-1 protein expression, disrupt equilibrium expression and endothelial NO synthase (eNOS) activation, subsequently impair flow-induced dilation (FID) in human skeletal muscle arterioles. Skeletal...
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for beige-to-white transition. Beige lacking Cdkn2a exhibit prolonged lifespan, male mice confer long-term metabolic protection from diet-induced obesity, along with enhanced energy expenditure improved glucose...
Blocking the androgen receptor (AR) activity is main goal of therapies for advanced prostate cancer (PCa). However, relapse with a more aggressive, hormone refractory PCa arises, which harbors restored AR activity. One mechanism such reactivation occurs through acquisition mutations that enable its activation by various steroidal and non-steroidal structures. Thus, natural chemical compounds contribute to inappropriate (androgen-independent) become an area intensive research. Here, we...
There is a high prevalence of hyperhomocysteinemia that has been linked to cardiovascular risk in obese individuals and could be attributed poor nutritional status folate vitamin B12. We sought examine the association between blood homocysteine (Hcy) folate, B12 levels vascular dysfunction morbidly adults using novel ex vivo flow-induced dilation (FID) measurements isolated adipose tissue arterioles. Brachial artery flow-mediated (FMD) was also measured. Subcutaneous visceral biopsies were...
Obesity is a major risk factor for cardiovascular disease. Blood-detected epigenetic profiles may serve as non-invasive clinically relevant biomarkers. Therefore, we investigated DNA methylation of genes involved in inflammation peripheral blood obese subjects and lean controls their correlation with cardiometabolic measurements. We obtained adipose tissue (AT) samples from bariatric patients (n = 24) control adults 24). AT-isolated arterioles were tested flow-induced dilation (FID)...
Vitamin D (VD) deficiency is a hallmark of obesity and vascular dysfunction. We sought to test the hypothesis that VD may contribute obesity-related dysfunction by inducing adipokine hypomethylation augmented expression. To this end, we collected blood adipose tissues (ATs) from cohort 77 obese participants who were classified as having mild, moderate, or severe deficiency. The body composition, reactivity, cardiometabolic profiles, DNA methylation 94 inflammation-related adipokines...
(1) Background: Persistent post-COVID-19 headaches are emerging as a significant post-infection symptom. This study investigates the clinical characteristics of persistent and potential role pro-inflammatory cytokines. (2) Methods: We conducted pilot case–control involving 84 participants divided into three groups: post-COVID with headache (n = 28), without healthy controls 28). The detailed characteristics, including pain intensity, were assessed using Visual Analog Scale (VAS). serum...
<p>GR recruitment to chromatin in key genes within statistically significant pathway from Figure 3E.</p>
<p>Supplementary methods, expanded version of sequencing methodology.</p>
<p>GR recruitment to chromatin in key genes correlated with neighborhood violence.</p>