A5085972671- Financial Risk and Volatility Modeling
- Stochastic processes and financial applications
- Stochastic processes and statistical mechanics
- Caveolin-1 and cellular processes
- Mathematical Dynamics and Fractals
- Market Dynamics and Volatility
- Complex Systems and Time Series Analysis
- Cytokine Signaling Pathways and Interactions
- Noise Effects and Management
- Nitric Oxide and Endothelin Effects
- Coal Properties and Utilization
- Rheumatoid Arthritis Research and Therapies
- Probability and Risk Models
- Ion Transport and Channel Regulation
- Wound Healing and Treatments
- Renin-Angiotensin System Studies
- Insurance, Mortality, Demography, Risk Management
- Hearing Loss and Rehabilitation
- Cell Adhesion Molecules Research
- Statistical Methods and Bayesian Inference
- Monetary Policy and Economic Impact
- Blood Coagulation and Thrombosis Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Statistical Methods and Inference
- Geometry and complex manifolds
Zhejiang Gongshang University
2016-2025
Guangxi Medical University
2025
Wuhan Prevention and Treatment Center for Occupational Diseases
2011-2024
Hubei University of Medicine
2024
University of Illinois Chicago
2013-2023
Beth Israel Deaconess Medical Center
2022-2023
Harvard University
2023
Sinopec (China)
2011-2022
China National Petroleum Corporation (China)
2021
State Key Laboratory of Food Science and Technology
2019
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of Editor-in-Chief. Molecular Therapy is retracting this article. After a reader raised concerns about article, Editor-in-Chief found that Figure 1 was reused without attribution to authors' previous work (Sun et al., 2018, Aging (Albany NY) 10, 973-987, https://dx.doi.org/10.18632/aging.101441) (although pan-cancer analysis E2F family...
Endothelial nitric oxide synthase (eNOS)-mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds an inactive conformation; however, mechanism Cav-1-mediated inhibition activated is unclear. Here Src-dependent Cav-1 phosphorylation negative feedback investigated. Using fluorescence resonance energy transfer (FRET) coimmunoprecipitation analyses, we observed increased interaction between following...
This paper describes the application of a novel multiobjective self-adaptive differential evolution (MOSADE) algorithm for simultaneous optimization component sizing and control strategy in parallel hybrid electric vehicles (HEVs). Based on an assist strategy, HEV optimal design problem is formulated as nonlinear constrained with competing noncommensurable objectives fuel consumption emissions. The driving performance requirements are considered constraints. proposed MOSADE approach adopts...
Caveolin 1 (Cav1) is a required structural component of caveolae, and its phosphorylation by Src associated with an increase in caveolae-mediated endocytosis. Here we demonstrate, using quantitative live-cell 4D, TIRF, FRET imaging, that endocytosis trafficking caveolae are Cav1 Tyr-14 phosphorylation-dependent conformational change, which spatially separates, or loosens, molecules within the oligomeric caveolar coat. When tracked TIRF spinning-disk microscopy, cells expressing...
We hypothesized that the maintenance of vascular homeostasis is critically dependent on expression and reciprocal regulation caveolin-1 (Cav-1) endothelial nitric oxide synthase (eNOS) in cells (ECs). Skeletal muscle biopsies from subjects with type 2 diabetes showed 50% less Cav-1 eNOS than those lean healthy controls. The Cav-1:eNOS ratio was 200:1 primary culture human ECs. small interfering RNA (siRNA) reduced protein gene association a twofold increase phosphorylation nitrate production...
Objective Levels of Toll‐like receptor 7 (TLR‐7) are elevated in rheumatoid arthritis (RA), but the impact on RA is unknown because endogenous ligand for TLR‐7 has not been identified. The aim this study was to identify a and determine its role pathogenesis RA. Methods presence an ligand, microRNA let‐7b (miR‐let‐7b), examined by real‐time polymerase chain reaction (PCR) analysis. Using knockdown cells, TLR‐7–knockout mice, or antagonist, specificity miR‐let‐7b as potential tested. mechanism...
E2F is a group of genes that encode family transcription factors (TFs) in higher eukaryotes and participate cell cycle regulation DNA synthesis mammalian cells. Evidence from lines, mouse models, human tissues indicates TFs are implicated lung cancer (LC) tumorigenesis. However, the diverse expression patterns prognostic values eight E2Fs have yet to be elucidated. In current study, we examined transcriptional survival data patients with LC ONCOMINE, GEPIA, Kaplan-Meier Plotter, cBioPortal...
Endothelial cells (ECs) control vascular permeability by forming a monolayer that is sealed extracellular junctions. Various mediators modulate the endothelial barrier acting on junctional protein complexes and therewith connected F-actin cytoskeleton. Different Rho GTPases participate in this modulation, but their mechanisms are still partly resolved. Here, we aimed to elucidate whether opening closure of associated with distinct localized RhoA activities at subcellular level.Live...
Hyperinsulinemia is a hallmark of insulin resistance-associated metabolic disorders. Under physiological conditions, maintains balance between nitric oxide (NO) and, the potent vasoconstrictor, endothelin-1 (ET-1). We tested hypothesis that acute hyperinsulinemia will preferentially augment ET-1 protein expression, disrupt equilibrium expression and endothelial NO synthase (eNOS) activation, subsequently impair flow-induced dilation (FID) in human skeletal muscle arterioles. Skeletal...
Although the role of IL-7 and IL-7R has been implicated in pathogenesis rheumatoid arthritis (RA), majority studies have focused on effect IL-7/IL-7R T cell development function. Our novel data, however, document that patients with RA greater disease activity higher levels IL-7, IL-7R, TNF-α monocytes, suggesting a feedback regulation between cascades myeloid cells is linked to chronic progression. Investigations into involved mechanism showed potent chemoattractant attracts IL-7R(+)...
In the present study, we tested hypothesis that chronic inflammation and oxidative/nitrosative stress induce caveolin 1 (Cav-1) degradation, providing an underlying mechanism of endothelial cell activation/dysfunction pulmonary vascular remodeling in patients with idiopathic arterial hypertension (IPAH). We observed reduced Cav-1 protein despite increased messenger RNA expression also nitric oxide synthase (eNOS) hyperphosphorylation human artery cells (PAECs) from IPAH. control lung...
Our aim was to examine the impact of TLR5 ligation in rheumatoid arthritis (RA) and experimental pathology. Studies were conducted investigate role on RA mouse myeloid cell chemotaxis or osteoclast formation, addition, uncover significance TNF-α function TLR5-mediated pathogenesis. Next, vivo mechanism action determined collagen-induced (CIA) local joint models. Last, evaluate importance RA, we used anti-TLR5 Ab therapy CIA mice. We show that agonist, flagellin, can promote monocyte...
Abstract Objective Data on noise-induced hearing loss (NIHL) in the automotive industry are rare. This pilot study aimed to investigate prevalence and determinants of NIHL among workers China. Methods A cross-sectional survey was conducted with 6557 participants from industry. The questionnaire administered, individual noise exposure level (LAeq.8h) were measured. Results Of participants, 96.43% male; median age 27.0 years 28.82% had defined as adjusted high-frequency (AHFNIHL). Concerning...
Type 2 diabetes mellitus (T2DM) is a risk factor for the development of late-onset Alzheimer's disease (AD). However, mechanism underlying AD largely unknown. Here we show that levels endothelial-enriched protein caveolin-1 (Cav-1) are reduced in brains T2DM patients compared with healthy aging, and inversely correlated β-amyloid (Aβ). Depletion Cav-1 recapitulated db/db ( Lepr db ) diabetic mice corresponds recognition memory deficits as well upregulation amyloid precursor (APP), BACE-1,...
Amid the widespread promotion of ESG concept, this study seeks to examine influence on high-frequency exchange rate volatility forecasting. Considering extensive utilization intraday information fin models, along with asymmetry effect and long-memory characteristics forecasting, robustness tests, we demonstrate that integrating into models significantly improves market This research contributes advancing theoretical understanding Realized-GARCH-type offers new insights impact foreign