A5100449854- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antimicrobial Peptides and Activities
- NF-κB Signaling Pathways
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Genetic Syndromes and Imprinting
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial metabolism and enzyme function
- Cancer Mechanisms and Therapy
- Glutathione Transferases and Polymorphisms
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Chemical Synthesis and Analysis
- Immune cells in cancer
- MXene and MAX Phase Materials
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2023
Zhengzhou University
2020
China Medical University
2019-2020
C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-regulated in serum and tumor tissues different cancers including hepatocellular carcinoma (HCC). However, the functions of CLEC3B HCC remains elucidated. The aim this study to analyze roles HCC. expression genes was evaluated by immunohistochemistry, western blot, real-time PCR, enzyme-linked immunosorbent assays, analysis on TCGA-LIHC database gene omnibus. Transmission electron microscopy immunofluorescence were applied detect...
Peptide stapling, by employing a stable, preformed alpha-helical conformation, results in the production of peptides with improved membrane permeability and enhanced proteolytic stability, compared to original peptides, provides an effective solution accelerate rapid development peptide drugs. Various reviews present stapling chemistries, anchoring residues one- or two-component cyclization, however, therapeutic stapled have not been systematically summarized, especially focusing on various...
TP53 is the most frequently mutated gene in human cancer, whereas tumors with wild-type develop alternative strategies to survive. Identifying new regulators of p53 reactivation would greatly contribute development cancer therapies. After screening entire genome liver cells, we identified lysyl oxidase-like 4 (LOXL4) as a novel regulator for activation. We found that 5-azacytidine (5-aza-CR) induces LOXL4 upregulation, subsequently binding basic domain via its low-isoelectric point region....
Circular RNA (circRNA) plays an essential role in the development and progression of various cancers. However, functions mechanisms circRNA colorectal liver metastasis have not been fully elucidated. We performed microarray analysis to screen differentially expressed pathology metastasis. Quantitative real‐time PCR was used detect expression hsa_circ_102049 (circ102049) cancer (CRC) samples. CRC cells were transfected with circ102049 overexpression vector or small interfering (si)RNA assess...
ABSTRACT Glioma, characterized by significant heterogeneity and aggressiveness, poses a formidable therapeutic challenge. Cuproptosis, newly identified form of regulated cell death driven copper imbalance, has recently emerged as pivotal factor in tumor biology. However, its role IDH1‐mutant gliomas remains poorly understood. Through comprehensive bioinformatics analysis publicly available datasets, we two distinct subtypes based on cuproptosis regulator expression profiles. Subtype G1...
Abstract Circular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs CRC is still its infancy. Herein, we discovered differential expressed (DECs) between tissues matched adjacent using deep sequencing further confirmed DECs expression by combining with another Gene Expression Omnibus dataset. Furthermore, validated top four upregulated...
An <italic>in situ</italic> detection of plasma exosomal microRNA for lung cancer diagnosis using duplex-specific nuclease and molybdenum disulfide nanosheets.
Owing to the aggressiveness and treatment-refractory nature of cancer, ideal candidates for early diagnosis treatment are needed. Golgi transport 1B (GOLT1B) has been associated with cellular malignant behaviors immune responses in colorectal lung but a systematic pan-cancer analysis on GOLT1B not conducted.The expression status clinical association The Cancer Genome Atlas (TCGA) were analyzed. Genetic methylation alterations explored. relationship between cell infiltration was also...
The genomic alterations of intrahepatic cholangiocarcinoma (ICC) in the Chinese population have not been fully revealed. Molecular profiling may provide a reference for clinical management, especially targeted therapy.A retrospective study was conducted 122 ICC patients. All patients' samples underwent next-generation sequencing (NGS), which analyzed 417 genes. genetic characteristics, management and therapeutic responses were analyzed.The most commonly mutated genes TP53 (34%), KRAS (25%)...
Hepatocellular carcinoma (HCC) is a highly lethal cancer and its underlying etiology remains understudied. The immense diversity complexity of the transcriptome hold potential to yield tumor‐specific transcripts (TSTs). Here, we showed that hundreds TSTs are frequently expressed in HCC by an assembling spliced junction analysis RNA sequencing raw data from approximately 1,000 normal tissues. Many were found be unannotated noncoding RNAs. We observed intergenic generated transcription...
Abstract β-1,4-N-acetylgalactosaminyltransferase I (B4GALNT1) is a key glycosyltransferase for gangliosides. Its aberrant expression has been observed in various cancers, and its potential roles tumor immunity were suggested recently. However, how B4GALNT1 regulate progression remains largely unknown. In this study, we aimed to investigate the of hepatocellular carcinoma (HCC), particularly reshaping immune microenvironment, evaluate beneficial effects targeting immunotherapy. Our data...
ZEB1 (a positive enhancer) and KLF5 negative silencer) affect transcription factors play inherently conserved roles in tumorigenesis multidrug resistance. In humans, the rs2295080T-allele at mTOR promoter locus has been associated with human cancer risk; however, 63 bp spacing of another SNP rs2295079 not identified. Here, we discovered, for first time, that (-78C/G) rs2295080 (-141G/T) formed linkage haplotypes, Ht1 (-78C/-141G) Ht2 (-78G/-141T) being dominant, which were distinct...
Background: Although immune checkpoint inhibitors (ICI) have revolutionized liver cancer treatment, some patients experience early tumor progression after therapy, missing the window for other potential treatments, such as neoadjuvant therapy. Therefore, identifying predictive factors is critical timely therapeutic adjustment and optimization of patient outcomes. Methods: This retrospective study enrolled with who received their first ICI combined targeted therapy at Fifth Medical Center PLA...
The prognosis of low-grade glioma (LGG) is highly variable and requires more accurate predictors. Ferroptosis, a newly discovered programmed cell death, has been demonstrated to play crucial role in some types tumors. However, prognostic prediction based on ferroptosis-related genes (FRGs) the influence tumor microenvironment (TME) LGG remains elusive. We derived expression profiles for from public databases. Based 25 FRGs LGG, two independent subtypes risk model were successfully...