A5033792942- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Vitamin D Research Studies
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Advanced Nanomaterials in Catalysis
- Air Quality and Health Impacts
- CRISPR and Genetic Engineering
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Diet and metabolism studies
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Telomeres, Telomerase, and Senescence
- Climate Change and Health Impacts
- Ginseng Biological Effects and Applications
- Mycotoxins in Agriculture and Food
- Electrochemical sensors and biosensors
- Dietary Effects on Health
Zhengzhou University
2015-2024
First Affiliated Hospital of Zhengzhou University
2022-2024
Nanjing University of Posts and Telecommunications
2023
Henan Institute of Education
2023
State Council of the People's Republic of China
2019
Southerners on New Ground
2018
Sichuan Agricultural University
2013
Jilin University
2009-2010
Neuromorphic electronics, being inspired by how the brain works, hold great promise to successful implementation of smart artificial systems. Among several neuromorphic hardware issues, a robust device functionality under extreme temperature is particular importance for practical applications. Given that organic memristors synapse applications are demonstrated room temperature, achieving performance at extremely low or high still utterly challenging. In this work, issue addressed tuning...
The prevalence of dyslipidemia continue to increase in recent decades China, however, little is known about the prevalence, awareness, treatment, control, and potential risk factors rural areas China. A total 39,207 participants aged 18–79 years were recruited for epidemiological research from Henan Rural Cohort study. age- sex-adjusted means (95% confidence intervals, CI) serum lipid levels or percentages control overall various population subgroups estimated compared by multiple linear...
Inspired by a fungicide, we designed 5-vinyloxazolidine-2,4-diones as new precursors of π-allylpalladium zwitterionic intermediates and developed palladium-catalyzed asymmetric (5 + 3) cycloaddition with azomethine imines (3 2) 1,1-dicyanoalkenes. Both reactions proceeded smoothly under mild reaction conditions to produce various chiral heterocyclic compounds in high yields excellent enantioselectivities. These results revealed that were type suitable precursor for palladium catalysis will...
Benzo-fused cyclic carbonates were designed and synthesized as a novel type of precursor π-allylpalladium zwitterionic intermediates.
Abstract Objective: The present study aimed to evaluate the validity and reproducibility of a thirteen-item FFQ regarding identification dietary conditions in rural population China. Design: A repeated first (FFQ1) approximately 4 weeks later (FFQ2). evaluated mean three consecutive 24 h diet recalls as reference measure. Setting: Cross-sectional study. Participants: Residents area Henan Province, which is located central region Results: total 295 individuals participated In addition, 123...
MicroRNA (miRNA) has emerged as a promising biomarker for disease diagnosis and potential therapeutic targets drug development. The detection of miRNA can serve noninvasive tool in diseases predicting prognosis. CRISPR/Cas12a system great nucleic acid due to its high sensitivity specificity, which been developed be versatile acid-based various fields. However, conversion from RNA DNA with or without amplification operation is necessary based on system, because dsDNA containing PAM sequence...
The precise determination of DNA methylation at specific sites is critical for the timely detection cancer, as closely associated with initiation and progression cancer. Herein, a novel ratiometric fluorescence method based on methylation-sensitive restriction enzyme (MSRE), CRISPR/Cas12a, catalytic hairpin assembly (CHA) amplification were developed to detect site-specific high sensitivity specificity. In detail, AciI, one commonly used MSREs, was employed distinguish methylated target from...
Elevated expression of let-7a-5p contributes to suppression lung cancer, in which let-7a-5p, as exosome cargo, can be transported from macrophages cancer cells, yet the role remains unclear. Utilizing bioinformatics methods and cellular experiments, this study was designed conducted identify regulatory network cancer. Bioinformatics analysis Kaplan-Meier survival revealed that could directly target BCL2L1, aberrant affects patients, confirmed A549 cells using luciferase reporter assay....
The phosphine-catalyzed tandem annulation of allenylic alcohols with 1,1-dicyanoalkenes has been developed, giving various bicyclic tetrahydrocyclopentafuran derivatives in 40-89% yields moderate to excellent diastereoselectivities. fused ring was furnished through a sequential (3 + 2) annulation/nucleophilic addition reaction. unusual nucleophilic an alkoxide ion cyano group led formation tetrahydrofuran having imino substituent.
Peanuts are usually with high moisture after harvest and must be dried to prevent mildew. Hot air drying is the most commonly used method for peanut drying. The purpose of this study was evaluate temperatures on qualities. In paper, fresh peanuts were solar radiation (control group) hot at 35-60°C until content reduced below 10%. physical (texture, damaged percentage red testa breakage kernel), physiological (germination) biochemical (the contents vitamin E aflatoxin B1; acidity values,...
Abstract Aims We aimed to investigate the association of serum testosterone with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) calculate proportion explained by obesity status on relationship. Materials Methods A case‐control study including 2775 participants was performed. Serum quantified liquid chromatography‐tandem mass spectrometry. Conditional logistic regression multivariable linear were performed estimate relationships between different status. Waist...
Population-based studies on the associations of long-term exposure to particulate matter (PM) with androgen and progesterone are still scant. Residential greenness is benefits health by promoting physical activity, reducing air pollution, improving mental health, but it remains unclear whether related levels among humans.This study aimed explore individual interactive effects PM residential serum testosterone rural Chinese adults.A total 6017 subjects were recruited from baseline Henan Rural...
Although exposure to ambient air pollution (AAP) increases the risk for arteriosclerotic cardiovascular disease (ASCVD), evidence on association of solid fuel use with ASCVD and its modified by remains limited.A total 16,779 adults were derived from Henan Rural Cohort Study. Concentrations pollutants (PM1, PM2.5, PM10, NO2) estimated a spatiotemporal model based satellites data. Solid was assessed self-reported questionnaire. The associations high 10-year explored using logistic regression...
The 5-allenyloxazolidine-2,4-diones had been synthesized as novel precursors of π-allyl palladium zwitterion and were applied in a palladium-catalyzed enantioselective (3 + 2) annulation by using barbiturate-derived alkenes the reaction partner presence an axially chiral phosphoramidite ligand. This proceeded smoothly under mild conditions, affording highly functionalized spirobarbiturate-γ-lactam derivatives excellent yields along with high diastereo- enantioselectivities. scale-up further...
A growing number of applications require simultaneous detection multiplexed nucleic acid targets in a single reaction, which enables higher information density combination with reduced assay time and cost. Clustered regularly interspaced short palindromic repeats (CRISPR) the CRISPR-Cas system have broad for acids due to their strong specificity, high sensitivity, excellent programmability. However, realizing is still challenging nonspecific collateral cleavage activity, limited signal...