A5070953775- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Parasite Biology and Host Interactions
- Long-Term Effects of COVID-19
- Parasitic Infections and Diagnostics
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Coccidia and coccidiosis research
- Parasites and Host Interactions
- Viral Infections and Vectors
- COVID-19 and healthcare impacts
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Vagus Nerve Stimulation Research
- Animal Virus Infections Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Research on Leishmaniasis Studies
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Helminth infection and control
Sam Houston State University
2020-2025
California Northstate University
2018
University of Illinois Urbana-Champaign
2015-2016
University of Illinois Chicago
2012-2016
Illinois College
2015-2016
Jesse Brown VA Medical Center
2015-2016
Rush University Medical Center
2014-2015
Cairo University
2014
Immune sera from convalescent patients have been shown to be effective in the treatment of infected with Severe Acute Respiratory Syndrome Virus (SARS-CoV) making passive immune therapy human monoclonal antibodies an attractive strategy for SARS. Previously, using Xenomouse (Amgen British Columbia Inc), we produced a panel neutralizing Human (HmAbs) that could specifically bind ectodomain SARS-CoV spike (S) glycoprotein. Some HmAbs were S1 domain specific, while some not. In this study,...
ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) and Ebola, Hendra, Nipah viruses are members of different viral families known causative agents fatal diseases. These depend on cathepsin L for entry into their target cells. The glycoproteins need to be primed by protease cleavage, rendering them active fusion with the host cell membrane. In this study, we developed a novel high-throughput screening assay based peptides, derived from aforementioned viruses, which contain...
Objective Levels of Toll‐like receptor 7 (TLR‐7) are elevated in rheumatoid arthritis (RA), but the impact on RA is unknown because endogenous ligand for TLR‐7 has not been identified. The aim this study was to identify a and determine its role pathogenesis RA. Methods presence an ligand, microRNA let‐7b (miR‐let‐7b), examined by real‐time polymerase chain reaction (PCR) analysis. Using knockdown cells, TLR‐7–knockout mice, or antagonist, specificity miR‐let‐7b as potential tested. mechanism...
Abstract Antibiotic-resistant Escherichia coli ( E. ) are common in retail poultry products. In this study, we aimed to isolate and characterize multidrug resistant (MDR) raw chicken meat samples collected from shops Sylhet division, Bangladesh, as well determine correlation between resistance phenotype genotype. A total of 600 swabs (divided equally broiler layer farms, n = 300 each) were the isolates identified 381) selected. Disc diffusion antimicrobial susceptibility assay showed these...
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Millions of cases and deaths to date have resulted in global challenge for healthcare systems. COVID-19 has high mortality rate, especially elderly individuals with pre-existing chronic comorbidities. There are currently no effective therapeutic approaches prevention treatment COVID-19. Therefore, identification therapeutics necessity. Terpenes...
Podocyte injury and loss mark an early step in the pathogenesis of various glomerular diseases, making these cells excellent targets for therapeutics. However, cell-based high-throughput screening assays rational development podocyte-directed therapeutics are currently lacking. Here, we describe a novel high-content screening-based phenotypic assay that analyzes thousands podocytes per condition 96-well plates to quantitatively measure dose-dependent changes multiple cellular features. Our...
In rheumatoid arthritis (RA), elevated serum interleukin-34 (IL-34) levels are linked with increased disease severity. IL-34 binds to 2 receptors, macrophage colony-stimulating factor receptor (M-CSFR) and syndecan 1, which coexpressed in RA macrophages. Expression of both 1 is strikingly the synovium, yet their mechanisms action remain undefined. This study was undertaken investigate mechanism RA.
Giardiasis is a major diarrheal disease affecting approximately 2.5 million children annually in developing countries. Several studies have reported the resistance of Giardia lamblia (G. lamblia) to multiple drugs. Therefore, identifying an effective drug for giardiasis necessity. This study examined antiparasitic effect Punica granatum (pomegranate) and evaluated its therapeutic efficacy rats infected with G. lamblia. In vitro showed high pomegranate peel ethanolic extract killing cysts as...
Studies were performed to uncover the significance of obesity in rheumatoid arthritis (RA) and preclinical models.Preclinical models used examine impact on disease onset remission. Conditioned media from RA adipose tissues investigate mechanism contributing joint neutrophil influx M1 macrophage differentiation observed early remission phases arthritis.We report that mice fed with high fat diet (HFD) have an earlier collagen-induced (CIA) compared regular diet. However, differences CIA...
Earlier, we have shown that GM-CSF derived bone marrow (BM) dendritic cells (G-BMDCs) can expand Foxp3+ regulatory T-cells (Tregs) through a TCR-independent, but IL-2 dependent mechanism required OX40L/OX40 interaction. While some reports suppression of autoimmunity upon treatment with an OX40 agonist, others exacerbation autoimmune disease instead. To better understand the basis for these differing outcomes, compared effects OX40L in 6-week-old pre-diabetic and 12-week-old near diabetic NOD...
Background: The COVID-19 pandemic has imposed several challenges on different populations all around the world, with stress being identified as one of major challenges. This study aims to investigate impact COVID-19-induced prevalence and severity anxiety and/or depression, factors that predict development coping strategies in Egyptian population during COVID 19 outbreak. Subjects Methods: is an observational cross-sectional online study. questionnaire our included five sections: demographic...