A5073218187- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Regulation of Appetite and Obesity
- Neurobiology and Insect Physiology Research
- Lipid metabolism and biosynthesis
- Phytochemistry and Biological Activities
- Apelin-related biomedical research
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Angiogenesis and VEGF in Cancer
- Phytochemical compounds biological activities
- Gastrointestinal motility and disorders
- Histone Deacetylase Inhibitors Research
- GDF15 and Related Biomarkers
- Ovarian function and disorders
- Clinical Nutrition and Gastroenterology
University of Illinois Chicago
2022-2024
Northwest A&F University
2024
South China Agricultural University
2016-2023
Key Laboratory of Guangdong Province
2017
Article18 July 2019Open Access Transparent process Succinate induces skeletal muscle fiber remodeling via SUCNR1 signaling Tao Wang Guangdong Province Key Laboratory of Animal Nutritional Regulation, College Science, South China Agricultural University, Guangzhou, Guangdong, Search for more papers by this author Ya-Qiong Xu Ye-Xian Yuan Ping-Wen Division Endocrinology, Department Medicine, The University Illinois at Chicago, IL, USA Cha Zhang Fan Li Li-Na Cong Yin Lin Xing-Cai Cai Can-Jun...
Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, demonstrated the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse model, which are independent OXGR1. We also showed effectively decreased blood hepatic gluconeogenesis DIO mice. By using transcriptomic liver-specific
Abstract Metabolites derived from the intestinal microbiota play an important role in maintaining skeletal muscle growth, function, and metabolism. Here, we found that D -malate (DMA) is produced by mouse microorganisms its levels increase during aging. Moreover, observed dietary supplementation of 2% DMA inhibits metabolism mice, resulting reduced mass, strength, number blood vessels, as well fiber type I/IIb ratio. In vitro assays demonstrate decreases proliferation vascular endothelial...
Article27 February 2020Open Access Source DataTransparent process Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation Yexian Yuan Guangdong Laboratory of Lingnan Modern Agriculture, Province Key Animal Nutritional Regulation National Engineering Research Center for Breeding Swine Industry, College Science, South China Agricultural University, Guangzhou, Search more papers by this author Pingwen Xu Division Endocrinology,...
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for beige-to-white transition. Beige lacking Cdkn2a exhibit prolonged lifespan, male mice confer long-term metabolic protection from diet-induced obesity, along with enhanced energy expenditure improved glucose...
Abstract Skeletal muscle weight loss is accompanied by small fiber size and low protein content. Alpha-ketoglutarate (AKG) participates in nitrogen metabolism. The effect of AKG on skeletal hypertrophy has not yet been tested, its underlying mechanism to be determined. In this study, we demonstrated that (2%) increased the gastrocnemius diameter mice. Our vitro study also confirmed dose synthesis C2C12 myotubes, which could effectively blocked antagonists Akt mTOR. effects were independent...
Skeletal muscle atrophy due to excessive protein degradation is the main cause for dysfunction, fatigue, and weakening of athletic ability. Endurance exercise effective attenuate atrophy, but underlying mechanism has not been fully investigated. a-Ketoglutarate (AKG) a key intermediate tricarboxylic acid cycle, which generated during endurance exercise. Here, we demonstrated that AKG effectively attenuated corticosterone-induced rescued dysfunction in Duchenne muscular dystrophy mouse model....
Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during contraction metabolism, characterized as a marker exercise exhaustion. However, physiological effects Hx on remain unknown. Herein, we demonstrate that chronic treatment with through dietary supplementation resulted fatigue impaired performance mice without affecting their growth development. uncoupling protein 2 (UCP2) expression muscle, led to...
There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT. CCL22 injection iWAT effectively promotes while blocking with antibodies prevent it. Mechanistically, the receptor, receptor 4 (CCR4), eosinophils its downstream focal adhesion...
Fibroblast growth factors (FGFs) have been known to be potent stimulators of vascular endothelial cell proliferation and angiogenesis. Recent experimental evidence indicates that basic FGF (bFGF) is also involved in modulation arterial pressure. In this study, we investigated the effects acidic (aFGF) bFGF on muscle microcirculation using isolated arterioles intact cremaster muscles at. microvessels, aFGF (10(-12)-10(-8) M) significantly increased arteriolar diameter a dose-dependent...
Endurance training and explosive strength training, with different contraction protein energy metabolism adaptation in skeletal muscle, are both beneficial for physical function quality of life. Our previous study found that chronic succinate feeding enhanced the endurance exercise mice by inducing muscle fiber-type transformation. The purpose this is to investigate effect acute administration on its potential mechanism. Succinate was injected mature explore strength. And C2C12 cells were...
It is well known that endurance training effective to attenuate skeletal muscle atrophy. Succinate a typical TCA metabolite, of which exercise could dramatically increase the content. The present study aimed investigate effect succinate on protein synthesis in muscle, and try delineate underlying mechanism. vitro revealed dose‑dependently increased C2C12 myotube along with enhancement phosphorylation levels AKT Serine/Threonine Kinase 1(Akt), mammalian target rapamycin, S6, eukaryotic...
Abstract Background Gut microbiota and their metabolites play a regulatory role in skeletal muscle growth development, which be known as gut-muscle axis. 3-phenylpropionic acid (3-PPA), metabolite produced by colonic microorganisms from phenylalanine the gut, presents large quantities blood circulation. But few study revealed its function development. Results Here, we demonstrated beneficial effects of 3-PPA on mass increase myotubes hypertrophy both vivo vitro. Further, discovered...
Laminarin, a type of β-glucan isolated from brown seaweeds, exhibits verity physiological activities, which include immunology modulation and antitumor function. To investigate the effect laminarin on energy homeostasis, mice were orally administrated with to test food intake, fat deposition, glucose homeostasis. Chronically, treatment significantly decreases high-fat-diet-induced body weight gain deposition reduces blood level tolerance. Acutely, enhances serum glucagon-like peptide-1...
Although the widely used anticoagulant drug heparin has been shown to have many other biological functions independent of its role, effects on energy homeostasis are unknown. Here, we demonstrate that level is negatively associated with nutritional states and treatment increases food intake body weight gain. By using electrophysiological, pharmacological, molecular biological, chemogenetic approaches, provide evidence by stimulating AgRP neurons increasing release. Our results support a...
Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) oleanolic (OA) from wild loquat were previously found capable of suppressing the proliferation A549 cells in vitro. In current study, nude mice to determine inhibitory effect UA OA on tumor formation vivo. The results demonstrate that reduced mice, increased expression Bid while...
Infertility is a global concern attributed to genetic defects, lifestyle, nutrition, and any other factors that affect the local metabolism niche microenvironment of reproductive system. 2-Oxoglutarate receptor 1 (OXGR1) abundantly expressed in testis; however, its cellular distribution biological function OXGR1 male system remain unclear. In current study, we demonstrated primarily epididymal smooth muscle cells (SMCs). Aging heat stress significantly reduced expression epididymis. Using...
Heparin, a widely used antithrombotic drug has many other anticoagulant-independent physiological functions. Here, we elucidate novel role of heparin in glucose homeostasis, suggesting an approach for developing heparin-targeted therapies diabetes.For serum levels and correlation analysis, 122 volunteer's plasma, DIO (4 weeks HFD) db/db mice serums were collected spectrophotometric determination. OGTT, ITT, 2-NBDG uptake muscle GLUT4 immunofluorescence detected chronic intraperitoneal...