A5065033494- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Migraine and Headache Studies
- Sympathectomy and Hyperhidrosis Treatments
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- Estrogen and related hormone effects
- Autophagy in Disease and Therapy
- Trigeminal Neuralgia and Treatments
University of Illinois Chicago
2021-2024
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for beige-to-white transition. Beige lacking Cdkn2a exhibit prolonged lifespan, male mice confer long-term metabolic protection from diet-induced obesity, along with enhanced energy expenditure improved glucose...
There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT. CCL22 injection iWAT effectively promotes while blocking with antibodies prevent it. Mechanistically, the receptor, receptor 4 (CCR4), eosinophils its downstream focal adhesion...
Abstract Migraine is one of the most common neurological disorders characterized by recurrent attacks typically throbbing and unilateral headaches, affecting up to 20% population worldwide. Despite high prevalence severity this primary headache disorder, it remains be a challenge fully understand treat migraine headaches. By characterizing validating mouse model, study aimed investigate functional contribution protein kinase C (PKC) isoforms in migraine. In study, we identified presence...
ABSTRACT De novo brown adipogenesis holds potential in combating the epidemics of obesity and diabetes. However, identity adipocyte progenitor cells (APCs) their regulation have not been extensively studied. Here through vivo lineage tracing, we observed that PDGFRβ+ pericytes give rise to developmental adipocytes, but those adult homeostasis. In contrast, TBX18+ contribute throughout both stages, though a depot-specific manner. Mechanistically, Notch inhibition promotes downregulation...
SUMMARY A potential therapeutic target to curb the obesity and diabetes epidemic is thermogenic beige adipocytes. However, adipocytes quickly transition into white upon removing stimuli. Here, we define critical role of Cdkn2a as a molecular pedal for beige-to-white transition. Beige lacking exhibit prolonged lifespan, mice are more resistant diet-induced obesity, along with enhanced energy expenditure improved glucose tolerance. Mechanistic studies demonstrate that promotes expression...