A5108147846- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Prostate Cancer Treatment and Research
- Particle Detector Development and Performance
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Dark Matter and Cosmic Phenomena
- S100 Proteins and Annexins
- Microscopic Colitis
- Estrogen and related hormone effects
- Radiopharmaceutical Chemistry and Applications
- Neutrino Physics Research
- Cancer, Lipids, and Metabolism
- Natural Antidiabetic Agents Studies
- FOXO transcription factor regulation
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Epigenetics and DNA Methylation
- Computational Physics and Python Applications
- Colorectal Cancer Surgical Treatments
- Cosmology and Gravitation Theories
- Protease and Inhibitor Mechanisms
University of Alabama at Birmingham
2022-2025
Universiti Sains Malaysia
2024
Budapest University of Technology and Economics
2024
Sulaimani Polytechnic University
2024
Abbott (Sweden)
2024
Islamic University of Madinah
2024
University of the Punjab
2013-2023
Kidney Centre
2022-2023
Jamia Millia Islamia
2023
Advanced Dermatology
2023
Abstract Chemoprevention has come of age as an effective cancer control modality; however, the search for novel agent(s) armamentarium chemoprevention continues. We argue that agents capable intervening at more than one critical pathway in carcinogenesis process will have greater advantage over other single‐target agents. Pomegranate fruit extract (PFE) derived from tree Punica granatum possesses strong antioxidant and antiinflammatory properties. was extracted with acetone analyzed based on...
Accumulating evidence suggests that codeletion of the tumor suppressor genes Pten and p53 plays a crucial role in development castration-resistant prostate cancer vivo. However, molecular mechanism underlying Pten-/p53-deficiency-driven tumorigenesis remains incompletely understood. Building upon insights gained from our studies with Pten-/p53-deficient mouse embryonic fibroblasts (MEFs), we report here hexokinase 2 (HK2) is selectively upregulated by combined loss cells. Mechanistically,...
Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms stroma cell contributions pathogenesis which may advance subtype-specific therapeutic development. We interrogate racially diverse human CRC samples analyze multiple independent external cohorts for a total 487,829 single cells enabling...
Delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, possesses antioxidant, anti-inflammatory, antiangiogenic properties. In this study, we provide evidence that it could be developed as novel agent against human prostate cancer (PCa). We observed delphinidin treatment to PCa LNCaP, C4-2, 22Rnu1, PC3 cells resulted dose-dependent inhibition of cell growth without having any substantial effect on normal epithelial cells. selected test model system because their...
Abstract Purpose: Cyclooxygenase-2 (COX-2) inhibitors hold promise for cancer chemoprevention; however, recent toxicity concerns suggest that new strategies are needed. One approach to overcome this limitation is use lower doses of COX-2 in combination with other established agents complementary mechanisms. In study, the effect (−)epigallocatechin-3-gallate (EGCG), a promising chemopreventive agent from green tea, was tested alone and specific on growth human prostate cells both vitro vivo....
We previously showed that the calcium-binding protein S100A4 is overexpressed during progression of prostate cancer (CaP) in humans and TRAMP (transgenic adenocarcinoma mouse prostate) model. tested a hypothesis gene plays role invasiveness human CaP may be associated with its metastatic spread. observed siRNA-mediated suppression significantly reduced proliferative invasive capability highly cells PC-3. evaluated mechanism through which controls by using macroarray containing 96 well...
Abstract Purpose: Notch, a type 1 transmembrane protein, plays key role in the development of many tissues and organ types. Aberrant Notch signaling, found wide variety human cancers, contributes to tumor development. Because Notch1 was be overexpressed prostate cancer (PCa) cells PCa tissue, we therefore tested our hypothesis that overexpression promotes invasion. Experimental Design: expression evaluated tissues. were transiently transfected with Notch1-specific small interfering RNAs...
Abstract Background: Matriptase, a type II transmembrane serine protease is involved in angiogenesis, degradation of extracellular matrix, and the progression some epithelial cancers. Here, we establish clinical significance matriptase its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), during human prostate cancer (CaP). Methods: The expression patterns HAI-1 were determined primary cultures normal (NHPE) cells, CaP cells LNCaP, DU-145, CWR22Rν1, PC-3, tissue samples 172...
Pancreatic cancer is an exceptionally aggressive disease, the treatment of which has largely been unsuccessful due to higher resistance offered by pancreatic cells conventional approaches such as surgery, radiation and/or chemotherapy. The aberration Ras oncoprotein linked induction multiple signaling pathways and apoptosis. Therefore, there a need for development new effective chemotherapeutic agents can target induce responsiveness death signals. In this study, human adenocarcinoma AsPC-1...
Abstract Purpose: Poor prognosis of metastatic melanoma mandates the development novel strategies for its treatment and prevention. In this study, effect lupeol, a diet-based triterpene, was determined on growth tumorigenicity human cells in vitro vivo. Experimental Design: Normal melanocytes, (451Lu) nonmetastatic (WM35) were treated with lupeol; growth, proliferation, apoptosis evaluated. Further athymic nude mice bearing 451Lu cell–originated tumors administered lupeol thrice week, tumor...
Abstract In prostate cancer, a fine balance between cell proliferation and apoptotic death is lost, resulting in increased cellular mass tumor progression. One approach to redress this imbalance control malignancy its preventive intervention through the use of dietary natural agents. Here, we investigated growth-inhibitory effect associated mechanisms Lupeol, triterpene present fruits vegetables, androgen-sensitive human cancer cells. Lupeol treatment resulted significant inhibition...
Death receptors of the tumor necrosis factor (TNF) receptor super family have been implicated in constitutive activation nuclear factor-kappa B (NF-kappaB) pancreatic cancer (PaC) cells. In this study, we demonstrate that fisetin, a natural flavonoid, induces apoptosis and inhibits invasion chemoresistant PaC AsPC-1 cells through suppression DR3-mediated NF-kappaB activation. Fisetin treatment resulted dose-dependent inhibition cell growth proliferation with concomitant induction apoptosis....
Overexpression of cellular FLICE-like inhibitory protein (cFLIP) is reported to confer chemoresistance in pancreatic cancer (PaC) cells. This study was designed investigate the effect lupeol, a dietary triterpene, on (a) apoptosis tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) therapy-resistant PaC cells overexpressing cFLIP and (b) growth human xenografts vivo. The lupeol treatment proliferation TRAIL/caspase-8/cFLIP machinery investigated. Next, cFLIP-overexpressing...
Abstract Purpose: Conventional therapies to treat prostate cancer (CaP) of androgen-dependent phenotype (ADPC) and castration-resistant (CRPC) are deficient in outcome which has necessitated a need identify those agents that could target AR for both disease types. We provide mechanism-based evidence lupeol (Lup-20(29)-en-3b-ol) is potent inhibitor androgen receptor (AR) vitro vivo. Experimental Design: Normal epithelial cell (RWPE-1), LAPC4 (wild functional AR/ADPC), LNCaP (mutant...