A5029053138- Peripheral Nerve Disorders
- Orthopedic Surgery and Rehabilitation
- Nerve Injury and Rehabilitation
- Periodontal Regeneration and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Oral microbiology and periodontitis research
- Shoulder and Clavicle Injuries
- Dental materials and restorations
- Oral and Maxillofacial Pathology
- Fatty Acid Research and Health
- Endodontics and Root Canal Treatments
- Natural Antidiabetic Agents Studies
- Vascular anomalies and interventions
- Phytoestrogen effects and research
- Electromagnetic Fields and Biological Effects
- Vascular Procedures and Complications
- Foot and Ankle Surgery
- melanin and skin pigmentation
- Phytochemicals and Medicinal Plants
- Tendon Structure and Treatment
- Dental Radiography and Imaging
- Immunotherapy and Immune Responses
- Microtubule and mitosis dynamics
- Birth, Development, and Health
- Shoulder Injury and Treatment
Manipal Academy of Higher Education
2014-2025
Yenepoya University
2025
Kasturba Medical College, Manipal
2009-2024
Western Kentucky University
2024
University of Kentucky
2024
Ras al-Khaimah Medical and Health Sciences University
1970-2023
College of Medical Sciences
1970-2023
Advanced Dermatology
2023
Shri Mata Vaishno Devi University
2017
Father Muller Medical College Hospital
2015
Abstract The MAGE-A, MAGE-B, and MAGE-C protein families comprise the class-I MAGE/cancer testes antigens, a group of highly homologous proteins whose expression is suppressed in all normal tissues except developing sperm. Aberrant class I MAGE occurs melanomas many other malignancies, have long been recognized as tumor-specific targets; however, their functions largely unknown. Here, we show that suppression induces apoptosis Hs-294T, A375, S91 MAGE-positive melanoma cell lines members...
We previously showed that the calcium-binding protein S100A4 is overexpressed during progression of prostate cancer (CaP) in humans and TRAMP (transgenic adenocarcinoma mouse prostate) model. tested a hypothesis gene plays role invasiveness human CaP may be associated with its metastatic spread. observed siRNA-mediated suppression significantly reduced proliferative invasive capability highly cells PC-3. evaluated mechanism through which controls by using macroarray containing 96 well...
Abstract Purpose: Notch, a type 1 transmembrane protein, plays key role in the development of many tissues and organ types. Aberrant Notch signaling, found wide variety human cancers, contributes to tumor development. Because Notch1 was be overexpressed prostate cancer (PCa) cells PCa tissue, we therefore tested our hypothesis that overexpression promotes invasion. Experimental Design: expression evaluated tissues. were transiently transfected with Notch1-specific small interfering RNAs...
Diabetic retinopathy (DR) stands as a prevalent complication in the eye resulting from diabetes mellitus, predominantly associated with high blood sugar levels and hypertension individuals age. DR is severe microvascular of both type I II mellitus leading cause vision impairment. The critical approach to combatting halting advancement lies effectively managing glucose pressure diabetic patients; however, this seldom achieved. Both human animal studies have revealed intricate nature condition...
Transient receptor potential melastatin (TRPM) is a subfamily of ion channels that are involved in sensing taste, ambient temperature, low pH, osmolarity, and chemical ligands. Melastatin 1/TRPM1, the founding member, was originally identified as melanoma metastasis suppressor based on its expression normal pigment cells skin eye but not aggressive, metastasis-competent melanomas. The role TRPM1 regulation melanocytes progression understood. Here, we studied relationship to growth...
To evaluate the effects of petroleum ether extract Cissus quadrangularis on proliferation rate bone marrow mesenchymal stem cells, differentiation cells into osteoblasts (osteoblastogenesis) and extracellular matrix calcification. This study also aimed to determine additive effect osteogenic media proliferation, calcification.MSCs were cultured in with or without for 4 weeks then stained alkaline phosphatase. Extracellular calcification was confirmed by Von Kossa staining. cultures control...
Smoking, which is an important risk factor for periodontitis, induces oxidative stress in the body and causes imbalance between reactive oxygen species (ROS) antioxidants, such as superoxide dismutase (SOD). In present study, influence of smoking on periodontium was determined by estimating levels SOD light heavy smokers with periodontitis.Seventy subjects age range 20 to 55 years, including 60 10 non-smokers (controls), were selected. Clinical parameters recorded plaque index (PI), probing...
The interaction of mobile phone radio-frequency electromagnetic radiation (RF-EMR) with the brain is a serious concern our society.We evaluated effect RF-EMR from phones on passive avoidance behaviour and hippocampal morphology in rats.Healthy male albino Wistar rats were exposed to by giving 50 missed calls (within 1 hour) per day for 4 weeks, keeping GSM (0.9 GHz/1.8 GHz) vibratory mode (no ring tone) cage. After experimental period, studied.Passive was significantly affected...
It has been established that human dental pulp and periodontal ligament contain a population of mesenchymal stem cells (MSCs). However, the phenotypic analysis in terms putative cell markers expressed by these populations is incomplete. relevant to understand whether derived from closely related tissues are programmed differently. The aim present study analyze depict distinct characteristics gaining insight into differences their immunophenotype. Dental tissue samples were obtained extracted...
A comparative evaluation of the gingival depigmentation by using Tetrafluoroethane cryosurgery and abrasion technique - 2 years follow up.Ten systemically healthy patients who were aged 18 to 36 selected for study. was used cryosurgical a coarse flame shaped bur. The presence or absence pigmentation tabulated, based on GPI (Gingival Pigmentation Index). For statistical analysis, Freidman's test used.The keratinization completed within week after application cryogen about 10 days done....
Whilst the world sees tremendous growth of mobile phone technology, radiofrequency electromagnetic radiation (RF-EMR) induced possible health effects have emerged as a topic recent day debate. The current study is designed to test hypothesis that chronic 900MHz exposure would potentially dysregulate stress response system (HPA axis) in vivo, via, its non-thermal mechanisms, leading alterations microarchitecture adrenal gland, vulnerable brain regions such hippocampus which may results...
Chronic neuroinflammation is a consequence of disease pathogenesis underlying neurological disorders at large. While the immune response that triggers inflammatory signaling cascades unresolved, its progression could cause functional damage to neurons and glial cells, including astrocytes, microglia, oligodendrocytes. Controlling neuroinflammatory early stage critical prevent irreversible tissue necrosis. application anti-inflammatory drugs standard practice, their protracted use known...
Melastatin 1 (MLSN1), originally identified as melanoma metastasis suppressor, represents a TRPM subfamily of transient receptor potential (TRP) proteins which serve diverse biological roles in wide variety cell types. Down-regulation MLSN1 expression human cutaneous melanoma, indicated by situ hybridization, appears to be prognostic marker for metastasis. However, the exact physiological function(s) MLSN1, mechanism(s) involved regulation its and role tumour progression are not yet clear....
The increasing incidence of postmenopausal osteoporosis and its related fractures have become global health issues in the recent days. Postmenopausal is most frequent metabolic bone disease; it characterized by a rapid loss mineralized tissue. Hormone replacement therapy has proven efficacious preventing but not desirable to many women due side-effects. Therefore we are need search natural compounds for treatment symptoms with no toxic effects. In present study, evaluated effect...
Dental esthetic needs of patients are increasing with a greater demand on pleasing look. This gets fulfilled not only by having healthy set dentition but also esthetically improved gingival component. Gingival melanin pigmentation is one the factors which determine smile an individual. Based available literature can vary depending whether it physiological or pathological. Its importance depends skin complexion patient and most important for determining treatment pigmentation. It necessary to...
Abstract Aim To describe the diagnosis and management of tooth 22 with a necrotic pulp severe periodontal destruction associated deep palatogingival groove extending to root apex. Summary Palatogingival grooves are uncommon in maxillary lateral incisors, but when present may contribute pathogenesis endodontic lesions. In case, prognosis was considered poor, as patient presented probing defect, advanced bone loss grade III mobility 22. Root canal treatment performed, followed by surgery,...