A5021921003- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Biblical Studies and Interpretation
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Renal Transplantation Outcomes and Treatments
- CAR-T cell therapy research
- Christian Theology and Mission
- Childhood Cancer Survivors' Quality of Life
- Multiple Myeloma Research and Treatments
- Catholicism and Religious Studies
- Theology and Philosophy of Evil
- Chronic Lymphocytic Leukemia Research
- Reformation and Early Modern Christianity
- Theology and Canon Law Studies
- Neutropenia and Cancer Infections
- American Constitutional Law and Politics
- Religion, Society, and Development
- Pentecostalism and Christianity Studies
- Religion and Society Interactions
- Neurological Complications and Syndromes
- Immune Cell Function and Interaction
- Cancer-related cognitive impairment studies
- Cytomegalovirus and herpesvirus research
University of Illinois Chicago
2004-2025
Incyte (United States)
2021-2025
University of Illinois System
2025
Northwestern Medical Faculty Foundation
2024
Northwestern University
1999-2023
Northwestern Medicine
2016-2022
Northwestern Memorial Hospital
2015-2018
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2013-2018
University College Cork
2004-2018
APC Microbiome Institute
2018
In Brief Nineteen subjects have more than 18 months’ follow-up in a phase IIb tolerance protocol HLA–mismatched recipients of living donor kidney plus facilitating cell enriched hematopoietic stem allografts (FCRx). Reduced intensity conditioning preceded allograft, followed the next day by FCRx. Twelve achieved stable chimerism and been successfully taken off immunosuppression (IS). We prospectively evaluated immune reconstitution immunocompetence. Return CD4+ CD8+ T central effector memory...
Highlights•Ruxolitinib can be integrated as pretransplantation treatment for patients with myelofibrosis.•A tapering strategy before transplantation did not result in any withdrawal-related side effects.•Graft failure and nonrelapse mortality remain significant despite ruxolitinib.AbstractWe evaluated the feasibility of ruxolitinib therapy followed by a reduced-intensity conditioning (RIC) regimen myelofibrosis (MF) undergoing 2-stage Simon phase II trial. The aims were to decrease incidence...
Abstract Acute graft-versus-host disease (GVHD) remains a barrier to successful allogeneic hematopoietic cell transplantation (HCT) outcomes. This multicenter, retrospective chart review describes progression, treatment patterns, hospitalizations, and clinical outcomes among 475 patients (≥12 years old) who developed grades II–IV acute GVHD after their first HCT (January 2014–June 2016). Median (interquartile range) age at was 55 (44–63) years. From the date of diagnosis, 190 (40.0%)...
The development of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) results in impaired physical function and quality life. However, limited data exist regarding the employment financial impact on patients caregivers. objective this study was to examine GVHD patient employment, disability leave, income, reliance caregivers, effects caregiver employment. Living With Chronic Patient Survey a cross-sectional online survey administered from...
Background: In the field of medical crowdfunding prediction, traditional statistical methods have long been standard. Machine learning algorithms gained popularity because they can model complex relationships between variables, capture interactions, and provide more accurate predictions, even when input variables are highly correlated. Furthermore, previous research has largely overlooked quantitative assessment success levels selection key predictors. To address these limitations, a novel...
Book Review| April 01 1990 Psychological Aspects of Pauline Theology Theology, Gerd Theissen and John P. Galvin. Wayne G. Rollins Search for other works by this author on: This Site Google Journal Biblical Literature (1990) 109 (1): 154–156. https://doi.org/10.2307/3267353 Cite Icon Share Facebook Twitter LinkedIn Email Permissions Citation Rollins; Theology. 1 January 1990; doi: Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar...
Abstract Background Chronic graft‐versus‐host disease (GVHD) is a potentially life‐threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) treatment for hematologic malignancies. There are limited patient‐reported data concerning symptom burden and effects on activities daily living (ADL). Methods The cross‐sectional Living With GVHD Patient Survey was administered online in the United States (May–August 2020) to participants aged ≥18 years who underwent HSCT,...
Lymphocyte granule-mediated apoptosis occurs by perforin-mediated intracellular delivery of granule-associated serine proteases (granzymes). A proteoglycan, namely serglycin, that contains chondroitin 4-sulfate (CS) glycosaminoglycans is present in the granules cytotoxic cells. Serglycin acts as scaffold for packaging positively charged granzymes and probably chaperones secreted extracellularly. To learn how interaction granzyme B (GrB) with serglycin might influence apoptotic potential this...
Book Review| December 01 1987 Jesus and Community: The Social Dimension of Christian Faith Faith, Gerhard Lohfink John P. Galvin. David L. Balch Search for other works by this author on: This Site Google Journal Biblical Literature (1987) 106 (4): 715–717. https://doi.org/10.2307/3260843 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Tools Permissions Cite Citation Balch; Faith. 1 1987; doi: Download citation...
Immunosenescence is a state of unbalanced immune responsiveness, characterized by diverse repertoire seemingly discreet and paradoxical alterations in all aspects immunity arising an aging-associated manner. We asked whether the ability apoptotic cells to elicit immunomodulatory responses (innate immunity; IAI) or IAI themselves might underlie confounding anomalies immunosenescence. explored this question examining, as function animal age, responsiveness murine macrophages on single cell...