A5027370048- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Viral Infections and Outbreaks Research
- Hormonal Regulation and Hypertension
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Peptidase Inhibition and Analysis
- Cardiovascular Effects of Exercise
- Cardiac Arrest and Resuscitation
- Stress Responses and Cortisol
- Cardiovascular and exercise physiology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neurological disorders and treatments
- Electrolyte and hormonal disorders
Christchurch Hospital
2015-2025
Frederick National Laboratory for Cancer Research
2023-2025
National Institute of Allergy and Infectious Diseases
2022-2025
National Institutes of Health
2025
Canterbury District Health Board
2013-2023
Lanzhou University
2022
Christ University
2021
Texas Cardiac Arrhythmia
2021
St David's Medical Center
2021
Massachusetts General Hospital
2021
Implantable cardioverter-defibrillators (ICDs) prevent sudden death from cardiac causes in selected patients but require the use of transvenous lead systems. To eliminate need for venous access, we designed and tested an entirely subcutaneous ICD system.First, conducted two short-term clinical trials to identify a suitable device configuration assess energy requirements. We evaluated four configurations 78 who were candidates implantation subsequently best 49 additional determine...
Background —Newly discovered circulating peptides, N-terminal pro–brain natriuretic peptide (N-BNP) and adrenomedullin (ADM), were examined for prediction of cardiac function prognosis compared with previously reported markers in 121 patients myocardial infarction. Methods Results —The association between radionuclide left ventricular ejection fraction (LVEF) N-BNP at 2 to 4 days ( r =−.63, P <.0001) 3 5 months =−.58, after infarction was comparable that C-terminal BNP far stronger than...
Background— The most frequent complications associated with implantable cardioverter-defibrillators (ICDs) involve the transvenous leads. A subcutaneous cardioverter-defibrillator (S-ICD) has been developed as an alternative system. This study evaluated safety and effectiveness of S-ICD System (Cameron Health/Boston Scientific) for treatment life-threatening ventricular arrhythmias (ventricular tachycardia/ventricular fibrillation). Methods Results— prospective, nonrandomized, multicenter...
Background— A recent landmark report has demonstrated that plasma B-type natriuretic peptide (BNP) measured in acute coronary syndromes independently predicts mortality, heart failure, and new myocardial infarction. After cardiac injury, left ventricular ejection fraction (LVEF) is also of prognostic significance plays a major role determining the therapeutic response. Methods Results— The present first from substantial (n=666) cohort patients with infarction to test utility concurrent...
Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study physician-directed patient self-management system targeting left atrial pressure.Forty patients with reduced or preserved ventricular ejection fraction and history New York Heart Association class III IV failure acute decompensation were implanted an investigational pressure monitor, readings acquired twice daily....
AimChronic right ventricle (RV) apical (RVA) pacing is standard treatment for an atrioventricular (AV) block but may be deleterious to left (LV) systolic function. Previous clinical studies of non-apical have produced conflicting results. The aim this randomized, prospective, international, multicentre trial was compare change in LV ejection fraction (LVEF) between ventricular and high septal (RVHS) over a 2-year study period.
The extravascular implantable cardioverter–defibrillator (ICD) has a single lead implanted substernally to enable pause-prevention pacing, antitachycardia and defibrillation energy similar that of transvenous ICDs. safety efficacy ICDs are not yet known.
Tecovirimat is available for the treatment of mpox (formerly known as monkeypox) in Europe and United States, on basis findings from efficacy studies animals safety evaluations healthy humans. Evidence randomized, controlled trials patients with lacking. We conducted a double-blind, placebo-controlled trial tecovirimat Democratic Republic Congo (DRC). Patients at least one skin lesion positive polymerase-chain-reaction results clade I MPXV were assigned 1:1 ratio to receive or placebo. All...
Background The aim of the present study was to assess short- and long-term effects multiple doses angiotensin II receptor antagonist losartan in heart failure. Methods Results A multicenter, placebo-controlled, oral, multidose (2.5, 10, 25, 50 mg once daily) double-blind comparison patients with symptomatic failure impaired left ventricular function (ejection fraction <40%). Invasive 24-hour hemodynamic assessment performed after first dose 12 weeks treatment. Clinical status tolerability...
OBJECTIVE--To document regional plasma concentrations of brain natriuretic factor (BNF) and their relations to concurrent atrial factor, cyclic guanosine monophosphate, haemodynamic state. DESIGN--Regional blood sampling from a systemic artery vein, renal coronary sinus together with indices in patients coming forward for left right cardiac catheterisation. SETTING--Tertiary referral centre. PATIENTS--22 consecutive unselected catheterisation or electrophysiological studies the course...
<h3>Objective</h3> To determine the relations of plasma levels brain natriuretic peptide (BNP), atrial factor (ANF), N-terminal ANF (N-ANF), cyclic guanosine monophosphate (cGMP; cardiac second messenger), and catecholamines to left ventricular function prognosis in patients admitted with acute myocardial infarction. <h3>Design</h3> Plasma hormones (radionuclide ventriculography) were measured 1–4 days after infarction 220 a single coronary care unit. Radionuclide scanning was repeated 3–5...
To determine the renal, endocrine and haemodynamic effects of an orally active inhibitor neutral endopeptidase EC 3.4.24.11 in essential hypertension.Two groups 12 white male patients with hypertension were treated candoxatril at 25 mg every h (group 1) or 200 2) for 5 days double-blind, placebo-controlled, crossover studies.Candoxatril enhanced natriuresis over initial 48 treatment. Twenty-four-hour diurnal hormone profiles (day 4) showed modest elevations plasma atrial natriuretic factor...
We describe the first human experience with a permanently implantable, direct left atrial pressure (LAP) monitoring system in ambulatory patients chronic heart failure.Eight established failure and at least 1 hospitalization or unplanned visit for parenteral therapy last year underwent device implantation under fluoroscopic guidance. All subjects received aspirin 150 mg clopidogrel 75 daily. Subjects measured LAP twice daily attended clinic regularly data upload calibration. Right...
This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those digoxin during maintenance diuretic therapy in patients mild to moderate heart failure. Compared placebo, resulted significantly improved exercise time (mean increase, 82 s vs 35 s) and New York Heart Association class (41% 22%), but did not. Digoxin increased ejection fraction (4.4% increase) compared (1.8% placebo (0.9% increase). The number ventricular premature beats decreased...
Although it is assumed that the human heart secretes atrial peptides, direct proof not available. We therefore measured immunoreactive natriuretic peptide levels in coronary sinus blood and simultaneously femoral arterial venous from patients before during stepwise incremental pacing of up to 200 beats per minute. Since fate circulating peptides unknown, we also concentrations across liver, kidney, lower limb, lung undergoing cardiological investigation. Peptide were higher than samples...
Christchurch, New Zealand, was struck by 2 major earthquakes at 4:36 am on 4 September 2010, magnitude 7.1 and 12:51 pm 22 February 2011, 6.3. Both events caused widespread destruction. Christchurch Hospital the region's only acute care hospital. It remained functional following both earthquakes. We were able to examine effects of cardiac presentations.Patients admitted under Cardiology in 3 week prior 5 weeks analysed, with corresponding control periods 2009 2010. Patients categorised based...
Background: Substernal lead placement of the extravascular implantable cardioverter-defibrillator (EV ICD) permits both defibrillation at thresholds similar to those seen with transvenous ICDs and effective antitachycardia pacing (ATP), while avoiding vasculature associated complications. The global Pivotal study has shown EV ICD system be safe through 6 months, but long-term experience yet published. We aim report performance safety throughout study. Methods: was a prospective, global,...
Abstract Aims The extravascular implantable cardioverter-defibrillator (EV ICD) has been shown to be safe and effective for patients at risk of sudden cardiac death, but little is known about EV ICD lead removal in humans. This analysis aimed characterize the experience thus far. Methods results was a retrospective removals from Pilot, Pivotal, Continued Access Studies. Patients with successful implant who underwent were included. main objective success. Ancillary objectives included...