A5079894175- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Genetic Associations and Epidemiology
- Anesthesia and Sedative Agents
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Microbial infections and disease research
- Mycotoxins in Agriculture and Food
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
The Ohio State University
2015-2024
Mount Sinai Medical Center
2023-2024
Columbia University
2024
The Ohio State University Wexner Medical Center
2014-2023
Boston Scientific (United States)
2023
Ohio Supercomputer Center
2022
University of Utah
2017
University of Auckland
2015-2016
Cleveland Clinic
2016
University of Duisburg-Essen
2015
Background— The most frequent complications associated with implantable cardioverter-defibrillators (ICDs) involve the transvenous leads. A subcutaneous cardioverter-defibrillator (S-ICD) has been developed as an alternative system. This study evaluated safety and effectiveness of S-ICD System (Cameron Health/Boston Scientific) for treatment life-threatening ventricular arrhythmias (ventricular tachycardia/ventricular fibrillation). Methods Results— prospective, nonrandomized, multicenter...
The entirely subcutaneous implantable cardioverter-defibrillator (S-ICD) is the first defibrillator that avoids placing electrodes in or around heart. Two large prospective studies (IDE [S-ICD System IDE Clinical Investigation] and EFFORTLESS [Boston Scientific Post Market S-ICD Registry]) have reported 6-month to 1-year data on S-ICD. objective of this study was evaluate safety efficacy a diverse population. Data from were pooled. Shocks independently adjudicated, complications measured...
Background— Brugada syndrome is a rare, autosomal-dominant, male-predominant form of idiopathic ventricular fibrillation characterized by right bundle-branch block and ST elevation in the precordial leads surface ECG. Mutations cardiac Na + channel SCN5A on chromosome 3p21 cause ≈20% cases syndrome; most mutations decrease inward current, some preventing trafficking channels to membrane. We previously used positional cloning identify new locus 3p24 large family with excluded as candidate...
AimsThe complex architecture of the human atria may create physical substrates for sustained re-entry to drive atrial fibrillation (AF). The existence sustained, anatomically defined AF drivers in humans has been challenged partly due lack simultaneous endocardial–epicardial (Endo–Epi) mapping coupled with high-resolution 3D structural imaging.
Atrial fibrillation (AF) shortens the atrial effective refractory period (ERP) and predisposes to further episodes of AF. The purpose this study was determine effect verapamil procainamide on these manifestations AF-induced electrical remodeling.In adult patients without structural heart disease, ERP measured before after AF pharmacological autonomic blockade administration (17 patients), (10 or saline (20 patients). then induced by rapid pacing. Immediately conversion, post-AF at...
Background — Brugada syndrome is a form of idiopathic ventricular fibrillation characterized by right bundle-branch block pattern and ST elevation (STE) in the precordial leads ECG. Sodium channel blockers increase STE. Mutations cardiac sodium SCN5A cause disorder, an implantable cardioverter-defibrillator often recommended for affected individuals. other genes have not been identified, it known if efficacy drug testing or malignancy arrhythmias correlates to gene defect. Methods Results We...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to reduce short- and long-term complications associated with transvenous ICD leads. Early multicenter studies included younger patients less left ventricular systolic dysfunction fewer comorbidities than cohorts traditional ICD.The purpose of this study characterize patient selection the acute performance S-ICD in a contemporary real-world setting.The Post-Approval Study is prospective registry involving 86 US...
Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in large national biobank, assessed whether refined phenotypic classification would facilitate discovery.We defined all-cause among 488 010 participants from UK Biobank performed genome-wide association analysis. phenotype by classifying individuals left ventricular dysfunction without coronary artery disease as having...
Structural remodeling of human atria plays a key role in sustaining atrial fibrillation (AF), but insufficient quantitative analysis structure impedes the treatment AF. We aimed to develop novel 3-dimensional (3D) structural and computational simulation tool that could reveal contributors reentrant AF drivers.High-resolution panoramic epicardial optical mapping coronary-perfused explanted intact (63-year-old woman, chronic hypertension, heart weight 608 g) was conducted during sinus rhythm...
AimsThe subcutaneous implantable cardioverter defibrillator (S-ICD) was introduced to overcome complications related transvenous leads. Adoption of the S-ICD requires implanters learn a new implantation technique. The aim this study assess learning curve for with respect implant-related complications, procedure time, and inappropriate shocks (IASs).
The human sinoatrial node (SAN) efficiently maintains heart rhythm even under adverse conditions. However, the specific mechanisms involved in SAN's ability to prevent failure, also referred as its robustness, are unknown. Challenges exist because three-dimensional (3D) intramural structure of SAN differs from well-studied animal models, and clinical electrode recordings limited only surface atrial activation. Hence, innovate translational study structural functional we integrated optical...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent transvenous ICD (TV-ICD) therapy. PRAETORIAN trial demonstrated that the S-ICD non-inferior TV-ICD with regard combined primary endpoint of inappropriate shocks complications. This prespecified secondary analysis evaluates all in trial.The an international, multicentre, randomized which 849 patients indication for therapy were receive S- (N =...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to avoid complications related transvenous (TV-ICD) leads. Device safety and efficacy were demonstrated previously with atypical clinical patients or limited follow-up. S-ICD PAS (Subcutaneous Implantable Cardioverter-Defibrillator System Post Approval Study) is a real-world, multicenter, registry of U.S. centers that designed assess long-term in diverse group implantation centers. Patients enrolled 86 standard...
Background Implantable cardioverter-defibrillator (ICD) therapy is integral to current for ventricular tachycardia. Patients with an ICD frequently require concomitant antiarrhythmic drug therapy. Despite this, some patients still receive frequent therapies Therefore, the purpose of this prospective study was determine utility ablation tachycardia in who experience therapies. Methods and Results Twenty-one consecutive despite were subjects study. The mean age 69±6 years, 17 men. ejection...
Background: Adenosine provokes atrial fibrillation (AF) with a higher activation frequency in right atria (RA) versus left (LA) patients, but the underlying molecular and functional substrates are unclear. We tested hypothesis that adenosine-induced AF is driven by localized reentry RA areas highest expression of adenosine A1 receptor its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels ( I K,Ado ). Methods: applied biatrial optical mapping immunoblot...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) provides an alternative to the transvenous (TV-ICD). Patients undergoing TV-ICD explantation may be eligible for reimplantation with S-ICD; however, information on safety outcomes in this complex population is limited.This analysis was designed provide outcome and data from S-ICD patients who received their device after explantation.Patients IDE Study EFFORTLESS Registry a prior explantation, as well those no (ICD), were...
Although sinoatrial node (SAN) dysfunction is a hallmark of human heart failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine role adenosine in SAN and tachy-brady arrhythmias chronic HF.We applied multiple approaches characterize structure, function, A1 receptor expression control (n=17) 4-month tachypacing-induced HF (n=18) dogs. Novel intramural optical mapping coronary-perfused right atrial preparations revealed that (10 μmol/L) markedly prolonged...
Background Concealed entrainment has been useful in guiding catheter ablation of monomorphic ventricular tachycardia patients with coronary artery disease. However, not all sites concealed result successful the targeted tachycardia. The purpose this prospective study was to identify factors at that demonstrate differentiate effective from ineffective target sites. Methods and Results In 14 consecutive hemodynamically stable disease, radiofrequency 26 tachycardias performed. Ablation...