A5038082004- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Trauma and Emergency Care Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Emergency and Acute Care Studies
- Trauma Management and Diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Healthcare Technology and Patient Monitoring
- Disaster Response and Management
- Lipoproteins and Cardiovascular Health
- Traumatic Brain Injury Research
Radboud University Nijmegen
2015-2025
Radboud University Medical Center
2015-2025
University Medical Center
2016-2025
Erasmus MC
2024
Amsterdam University Medical Centers
2024
University of Amsterdam
1995-2024
Radboud Institute for Molecular Life Sciences
2019
Institute of Cardiology
2019
Technische Universität Dresden
2007
Netherlands Heart Institute
2002
Catheter ablation of atrial fibrillation is typically performed with uninterrupted anticoagulation warfarin or interrupted non-vitamin K antagonist oral anticoagulant therapy. Uninterrupted a anticoagulant, such as dabigatran, may be safer; however, controlled data are lacking. We investigated the safety dabigatran versus in patients undergoing fibrillation.In this randomized, open-label, multicenter, trial blinded adjudicated end-point assessments, we randomly assigned scheduled for...
The subcutaneous implantable cardioverter-defibrillator (ICD) was designed to avoid complications related the transvenous ICD lead by using an entirely extrathoracic placement. Evidence comparing these systems has been based primarily on observational studies.We conducted a noninferiority trial in which patients with indication for but no pacing were assigned receive or ICD. primary end point composite of device-related and inappropriate shocks; margin upper boundary 95% confidence interval...
<b>Objective</b> To determine whether the treatment effect of apixaban versus warfarin differs with increasing numbers concomitant drugs used by patients atrial fibrillation. <b>Design</b> Post hoc analysis performed in 2015 results from ARISTOTLE (apixaban for reduction stroke and other thromboembolic events fibrillation)—a multicentre, double blind, dummy trial that started 2006 ended 2011. <b>Participants</b> 18 201 participants. <b>Interventions</b> In trial, were...
Bystander cardiopulmonary resuscitation (CPR) is crucial for survival after cardiac arrest but not performed in most cases. New, low-cost, and easily accessible training methods, such as virtual reality (VR), may reach broader target populations, data on achieved CPR skills are lacking.To compare quality between VR face-to-face training.Randomized noninferiority trial with a prospective randomized open blinded end point design. Participants were adult attendees from the science section of...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent transvenous ICD (TV-ICD) therapy. PRAETORIAN trial demonstrated that the S-ICD non-inferior TV-ICD with regard combined primary endpoint of inappropriate shocks complications. This prespecified secondary analysis evaluates all in trial.The an international, multicentre, randomized which 849 patients indication for therapy were receive S- (N =...
Unwitnessed out-of-hospital cardiac arrest is associated with low survival chances because of the delayed activation emergency medical system in most cases. Automated detection and alarming using biosensor technology would offer a potential solution to provide early help. We developed validated an algorithm for automated circulatory wrist-derived photoplethysmography from patients induced arrests.
Background — Despite the use of aspirin, reocclusion infarct-related artery occurs in ≈30% patients within first year after successful fibrinolysis, with impaired clinical outcome. This study sought to assess impact a prolonged anticoagulation regimen as adjunctive aspirin prevention and recurrent ischemic events fibrinolysis for ST-elevation myocardial infarction. Methods Results At coronary angiography <48 hours fibrinolytic therapy, 308 receiving intravenous heparin had patent...
BACKGROUND: Approximately 15% of saphenous vein grafts (SVGs) occlude during the first year after coronary artery bypass graft surgery (CABG) despite aspirin use. The POPular CABG trial (The Effect Ticagrelor on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting Surgery) investigated whether ticagrelor added to standard improves SVG patency at 1 CABG. METHODS: In this investigator-initiated, randomized, double-blind, placebo-controlled, multicenter trial,...
The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) showed noninferiority subcutaneous implantable cardioverter defibrillator (S-ICD) compared with transvenous (TV-ICD) regard to inappropriate shocks complications. In contrast TV-ICD, S-ICD cannot provide antitachycardia pacing for monomorphic ventricular tachycardia. This prespecified secondary analysis evaluates appropriate therapy whether reduces the...
<h3>Importance</h3> Increased bystander cardiopulmonary resuscitation (CPR) is essential to improve survival after cardiac arrest. Although most studies focus on technical CPR skills, the randomized Lowlands Saves Lives trial prespecified a follow-up survey other important aspects that affect widespread performance of CPR. <h3>Objective</h3> To investigate willingness perform stranger, theoretical knowledge retention, and dissemination awareness 6 months undergoing short face-to-face virtual...
Parkinson's disease (PD) is a neurodegenerative disorder with wide range of motor and non-motor symptoms. Despite optimal medical management, PD still results in high disability rate secondary complications many patients lead sedentary lifestyle, which turn also associated higher co-morbidity mortality. Exercise has been explored as strategy to reduce suggests that it not only provides general health benefits, but may provide symptomatic relief. If this holds true exercise would be very...
Abstract Aims This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock mortality identify subgroups with insufficient benefit from ICD implantation. Methods results We recruited patients scheduled primary prevention implantation reduced left ventricular function. Bootstrapping-based Cox proportional hazards Fine Gray competing risk likely candidate predictors were developed all-cause shock, respectively....