Marco Canepa
A5076063517- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Parathyroid Disorders and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Peptidase Inhibition and Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Medical Imaging and Pathology Studies
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Digestive system and related health
- Bone health and osteoporosis research
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Potassium and Related Disorders
- Gastrointestinal disorders and treatments
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
Ospedale Policlinico San Martino
2016-2025
University of Genoa
2016-2025
Sequoia (United States)
2024
SEQUOIA (Italy)
2024
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2024
Azienda Sanitaria Universitaria Integrata di Trieste
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2023
A. O. Ordine Mauriziano di Torino
2023
University of Turin
2023
University of Trieste
2023
Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information available on the pattern and determinants longitudinal change in PWV with aging. Such crucial to elucidating mechanisms underlying stiffness design interventions retard it. Between 1988 2013, we collected 2 9 serial measures 354 men 423 women Baltimore Longitudinal Study Aging, who were 21 94 years age free clinically significant disease....
BACKGROUND: The extent of myocardial bone tracer uptake with technetium pyrophosphate, hydroxymethylene diphosphonate, and 3,3-diphosphono-1,2-propanodicarboxylate in transthyretin amyloid cardiomyopathy (ATTR-CM) might reflect cardiac burden be associated outcome. METHODS: Consecutive patients ATTR-CM who underwent diagnostic scintigraphy acquisition whole-body planar single-photon emission computed tomography (SPECT) images from the National Amyloidosis Centre 4 Italian centers were...
Lay summary•In this manuscript we describe the phenotype and prognosis of patients with cardiac amyloidosis (CA) hypertension diabetes.•A history is common in a diagnosis should not be overlooked these patients.•Diabetes may influence amyloidosis.AbstractBackgroundHypertension diabetes increase risk adverse events general population cardiomyopathies, however, their role still unclarified.Aimsto evaluate effect on clinical outcomes CA.MethodsData from 5 Italian Amyloidosis Referral Centres...
Background Intracardiac thrombosis is reported to occur frequently in cardiac amyloidosis (CA). However, data regarding arterial thrombo-embolic events (AEs) CA are limited. We aimed at assessing prevalence, clinical characteristics and predictors of AEs a large multicentric cohort.Methods results Four-hundred-six consecutive patients (134 AL, 73 ATTRm 199 ATTRwt) from 5 Italian referral centres were retrospectively evaluated followed-up for median time 19 months. Thirty-one (7.6%) suffered...
Low QRS voltages (LQRSVs) are a common electrocardiographic feature in patients with light chain amyloidosis (AL) and transthyretin (ATTR) cardiac (CA).The aim of this study was to identify clinical echocardiographic correlates LQRSV investigate their prognostic significance CA.This multicenter, retrospective performed 6 CA referral centers including consecutive AL ATTR CA. LQRSVs were defined as amplitude ≤5 mm (0.5 mV) all peripheral leads. The outcome cardiovascular (CV)...
Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization pathways leading to ATTRwt-CA diagnosis is key importance, and potentially informative disease course prognosis. The aim this study was describe the characteristics contemporary diagnosis, their potential association with survival.This a retrospective patients diagnosed at 17 Italian referral centres for CA. Patients were categorized into different 'pathways' according...
Cardiologists are encountering a growing number of cancer patients with ischaemic heart disease (IHD). Several factors account for the interrelationship between these two conditions, in addition to improving survival rates population. Established cardiovascular (CV) risk factors, such as hypercholesterolaemia and obesity, predispose both IHD cancer, through specific mechanisms via low-grade, systemic inflammation. This latter is also fuelled by clonal haematopoiesis indeterminate potential....
The importance of vitamin D for bone health has long been acknowledged. Recent evidence suggests that can also play a role in reducing the risk several other diseases, including cardiovascular disease.The aim this study is to test hypothesis 25-hydroxyvitamin (25-OH D) an independent cross-sectional correlate central arterial stiffness normative aging population.We conducted analysis.We studied 1228 healthy volunteers (50% males; age, 70±12 yr) Baltimore Longitudinal Study Aging.We measured...
Abstract Background Rare cases of severe myocarditis are reported during treatment with nivolumab. Troponin, a biomarker cardiac damage, is key component the diagnostic workup many disorders, including myocarditis. This study investigates role troponin to assess involvement nivolumab therapy for non-small cell lung cancer (NSCLC). Materials and Methods We evaluated 59 NSCLC patients, analyzing serum samples collected within translational research study. Troponin above upper normal limit...
Background Chronic cardiotoxicity is less common in male than female patients receiving doxorubicin and other anthracyclines at puberty adolescence. We hypothesized that this sex difference might be secondary to distinct activities of hormones on cardiomyocyte senescence, which thought central the development long‐term anthracycline cardiomyopathy. Methods Results H9c2 cells neonatal mouse cardiomyocytes were exposed with or without prior incubation testosterone 17β‐estradiol, main androgen...
Background Hypertrophic cardiomyopathy ( HCM ) is a common inherited cardiac disease characterized by varying degrees of left ventricular outflow tract obstruction. In large cohort, we compare the outcomes among 3 different hemodynamic groups. Methods and Results We prospectively enrolled patients fulfilling standard diagnostic criteria for from January 2005 to June 2015. Detailed phenotypic characterization, including peak pressure gradients at rest after provocation, was measured...
A significant inter‐arm difference in systolic blood pressure ( IADSBP ) has recently been associated with worse cardiovascular outcomes. The authors hypothesized that part of this association is mediated by arterial stiffness, and examined the relationship between carotid‐femoral pulse wave velocity CF ‐ PWV a sample from Baltimore Longitudinal Study Aging. Of 1045 participants, 50 (4.8%) had an ≥10 mm Hg at baseline, 629 completed data ≥2 visits (for total 1704 during 8 years). was...