A5003328887- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Peptidase Inhibition and Analysis
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Vascular Procedures and Complications
University of Ferrara
2019-2025
Arcispedale Sant'Anna
2016-2024
University of Florence
2023
University of Messina
2023
Policlinico San Matteo Fondazione
2023
British Heart Foundation
2020-2021
Maria Cecilia Hospital
2021
University of Glasgow
2019-2020
Cardiovascular Institute of the South
2016
Background: The DAPA-HF trial (Dapagliflozin and Prevention of Adverse-Outcomes in Heart Failure) showed that dapagliflozin added to other guideline-recommended therapies reduced the risk mortality heart failure hospitalization improved symptoms patients with ejection fraction. We examined effects according age, given potential concerns about efficacy safety elderly. Methods: Patients New York Association functional class II or greater a left ventricular fraction ≤40% modest elevation...
Abstract Aims To perform evaluation of widely embraced bone scintigraphy-based non-biopsy diagnostic criteria (NBDC) for ATTR amyloid cardiomyopathy (ATTR-CM) in clinical practice, and to refine serum free light chain (sFLC) ratio cut-offs that reliably exclude monoclonal gammopathy (MG) chronic kidney disease. Methods results A multi-national retrospective study 3354 patients with suspected or histologically proven cardiac amyloidosis (CA) referred specialist centres from 2015 2021;...
Importance Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages no heart failure (HF) symptoms and a wide range of infiltration. Objective To characterize the clinical phenotype natural history asymptomatic patients ATTR Design, Setting, Participants This cohort study analyzed data all 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023. Inclusion criteria were infiltration, defined as an...
Concern about hypotension often leads to withholding of beneficial therapy in patients with heart failure and reduced ejection fraction (HFrEF). We evaluated the efficacy safety dapagliflozin, which lowers systolic blood pressure (SBP),according baseline SBP Dapagliflozin Prevention Adverse Outcomes Heart Failure trial (DAPA-HF).
Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization pathways leading to ATTRwt-CA diagnosis is key importance, and potentially informative disease course prognosis. The aim this study was describe the characteristics contemporary diagnosis, their potential association with survival.This a retrospective patients diagnosed at 17 Italian referral centres for CA. Patients were categorized into different 'pathways' according...
The purpose of this study was to investigate the effects mineralocorticoid receptor antagonists (MRAs) on systolic blood pressure (SBP) and outcomes according baseline SBP in patients with heart failure reduced ejection fraction (HFrEF).MRAs are greatly underused HFrEF, often because fear adverse events. Concern about hypotension has been raised by demonstration that MRAs particularly effective treatment for resistant hypertension.The effect MRA therapy studied 4,396 HFrEF randomized RALES...
Abstract Background The number of older adults admitted to hospital for acute coronary syndrome (ACS) has increased worldwide. aim this study was determine which scale frailty or physical performance provides incremental improvements in risk stratification after ACS. Methods A prospective cohort 402 (≥70 years) ACS patients were enrolled. Data about baseline characteristics, Global Registry Acute Coronary Events (GRACE), and Thrombolysis Myocardial Infarction (TIMI) scores collected. Before...
Objective To establish the benefits of an early, tailored and low-cost exercise intervention in older patients hospitalised for acute coronary syndrome (ACS). Methods The study was a multicentre, randomised assessment with ACS ≥70 years reduced physical performance (as defined by short battery (SPPB), value 4–9). included four supervised sessions (1, 2, 3, 4 months after discharge) home-based exercises. control group attended health education programme only. outcomes were 6-month 1-year...
Abstract Aims The present analysis from the Functional Assessment in Elderly Myocardial Infarction Patients with Multivessel Disease (FIRE) trial aims to explore significance of pre-admission physical activity and assess whether benefits physiology-guided complete revascularization apply consistently sedentary active older patients. Methods results aged 75 years or more myocardial infarction (MI) multivessel disease were randomized receive culprit-only strategy. primary outcome was a...
ABSTRACT Background There is limited evidence on the safety and efficacy of biodegradable‐polymer sirolimus‐eluting ultra‐thin stent (BP‐SES) in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI). Aims This study aims to evaluate clinical outcomes HBR treated with BP‐SES ≤ 30‐day dual antiplatelet therapy (DAPT) regimen. Methods A systematic review was conducted identify relevant studies involving who underwent PCI (Supraflex Cruz). Individual...
Immune checkpoint molecules like cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1) or its ligand, ligand (PD-L1), play a critical role in regulating the immune response, and inhibitors (ICIs) targeting these checkpoints have shown clinical efficacy cancer treatment; however, their use is associated with immune-related adverse events (irAEs), including cardiac complications. The prevalence of irAEs, particularly myocarditis, relatively low, but they can become severe...
About one in seven elderly patients with severe calcific aortic stenosis (AS) also have ATTR amyloid cardiomyopathy (AC-TTR). The reasons for this close association are not fully known, but the two entities only related by common epidemiology. For example, it is possible to hypothesize that an amyloidotic infiltration of valve, even partial, can act as a trigger development endothelial damage and subsequent calcification. Another hypothesis increased myocardial strain induced AS may locally...
The therapy of transthyretin (TTR)-related cardiac amyloidosis consists, on the one hand, prevention and management complications (supportive therapy) other treatments aimed at interrupting or slowing down production deposition fibrils (disease-modifying therapy). This definition includes drugs that act different phases amyloidogenesis: (i) silencing gene encoding TTR (small interfering RNA: patisiran, vutrisiran; antisense oligonucleotides: inotersen, eplontersen; new CRISPR Cas-9 drug...
Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) they represent independent risk factors for disability, morbidity, hospital readmission mortality. Regular exercise represents a means improving functional capacity. Nevertheless, its clinical benefit has been less investigated the early phase ACS. The HULK trial aims to investigate of an early, tailored low-cost activity intervention comparison standard care ACS with reduced...
Abstract Aims In patients undergoing cardiac implantable electronic device (CIED) intervention, routine pre-procedure antibiotic prophylaxis is recommended. A more powerful protocol has been suggested in at high risk of infection. Stratification individual infective could guide the before CIED procedure. Methods and results Patients surgery were stratified according to Shariff score low risk. ‘low-risk’ group treated with only two administrations while ‘high-risk’ a prolonged 9-day protocol,...
The revascularization strategy to pursue in older myocardial infarction (MI) patients with multivessel disease (MVD) is currently unknown. For this reason, while waiting for the results of dedicated trials, we sought compare a complete versus culprit-only MI by merging data from four registries.The inclusion criteria target population present study were (i) age ≥ 75 years; (ii) (STE or NSTE); (iii) MVD; (iv) successful treatment culprit lesion. Propensity scores (PS) derived using logistic...