A5049973902- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Sarcoidosis and Beryllium Toxicity Research
- Non-Invasive Vital Sign Monitoring
- Connective Tissue Growth Factor Research
- Pericarditis and Cardiac Tamponade
- Cardiovascular Disease and Adiposity
IRCCS Istituto Auxologico Italiano
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2025
University of Foggia
2023-2024
University of Milano-Bicocca
2014-2021
Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization pathways leading to ATTRwt-CA diagnosis is key importance, and potentially informative disease course prognosis. The aim this study was describe the characteristics contemporary diagnosis, their potential association with survival.This a retrospective patients diagnosed at 17 Italian referral centres for CA. Patients were categorized into different 'pathways' according...
Raising the suspicion of amyloid cardiomyopathy (AC) is essential to orient additional tests and achieve an early diagnosis before development clinically overt disease.1,2 Notably, echocardiography technique with greatest potential raise AC by detecting specific signs ('red-flags') cardiac infiltration.3 However, epidemiology echocardiographic red-flags in general population patients referred without clinical their diagnostic accuracy remain unknown.4,,5 This a national, multicentre,...
•LASr and RASr are associated with AF recurrence in patients undergoing ECV.•RASr provides incremental prognostic value over LASr.•Speckle-tracking evaluation of both atria is pivotal for a better risk stratification BackgroundAlthough the assessment left atrial (LA) mechanics has been reported to refine fibrillation (AF) prediction, it doesn't completely predict recurrence. The potential added role right (RA) function this setting unknown. Accordingly, study sought evaluate RA longitudinal...
Abstract Background/Introduction The diagnosis of transthyretin-related cardiac amyloidosis (ATTR-CA), while often suggested by red flags observed in echocardiography, still requires a lengthy and multi-step process. Recent evidence indicates the feasibility using radiomics on echocardiographic images (i.e., echomics) for early characterization myocardial texture anomalies ATTR-CA. Aims This study aims to develop radiomic-based model (ATTR-CA) characterizing tissue through echocardiography...
Abstract Background In hypertrophic cardiomyopathy (HCM) patients, quantification of left ventricular (LV) mass carries important prognostic implications. Two-dimensional echocardiography (2DE) has limited accuracy for LV calculation, due to plane position errors, geometric assumptions and asymmetric distribution hypertrophy in HCM. Purpose We aimed explore: (1) the three-dimensional (3DE) vs 2DE quantify HCM compared cardiac magnetic resonance (CMR); (2) relationship 3DE with non-sustained...
Abstract Background Differently from the effective regurgitant orifice area (EROA) and volume (RegVol), RegFr directly accounts for size function of right ventricle (RV). Objectives To assess relationship between fraction (RegFr) evaluated using three-dimensional echocardiography (3DE) outcome in patients with secondary tricuspid regurgitation (STR). Methods 331 at least mild STR were enrolled. was computed as ratio RegVol, calculated proximal isovolumic surface (PISA) method by Doppler...
Abstract Background In hypertrophic cardiomyopathy (HCM), atrial fibrillation (AF) is a marker of disease progression and worse outcome, increasing the risk thromboembolic events. Identification HCM patients (pts) at AF pivotal for their clinical management follow-up. Purpose We aimed to explore whether detailed echocardiographic evaluation left atrium (LA) remodeling function in pts might improve predictive value new compared standard parameters. Methods consecutive referred our...
Abstract Introduction Secondary tricuspid regurgitation (STR) is currently classified into atrial (A-STR) and ventricular (V-STR) phenotypes. In the multiparametric definition framework of A-STR, an end-systolic (ES) right (RA) to (RV) volume ratio ≥1.5 has been proposed among criteria that favor diagnosis A-STR over V-STR. However, no previous study tested or validated this specific cut-off value. Purpose We aimed determine threshold value ES RA:RV for distinguishing V-STR in a large cohort...
Abstract Background The cut-off value for defining severe secondary tricuspid regurgitation (STR) using the planimetry of color Doppler three-dimensional echocardiography (3DE) vena contracta area (VCA) has been determined in previous studies based on its correlation with values effective regurgitant orifice (EROA), obtained proximal isovolumic surface (PISA) method, patients STR. However, association VCA outcomes not examined these studies. Purpose We sought to 1) identify 3DE associated an...
The role of repeated infusions Levosimendan (LEVO) in patients with chronic advanced heart failure is still unclear. Thirty-three presenting clinical deterioration were randomized 2:1 to receive monthly LEVO (n = 22) or Furosemide (Controls, n 11). At the first drug's administration, noninvasive hemodynamic evaluation was performed; before and after each infusion, we assessed NYHA class, systolic diastolic function, functional mitral regurgitation, brain natriuretic peptide (BNP) levels....
The implantable cardioverter-defibrillator (ICD) is a life-saving therapy in patients with hypertrophic cardiomyopathy (HCM) at risk of sudden cardiac death. Implantable complications are concern. subcutaneous ICD (S-ICD) does not use transvenous leads and expected to reduce complications. However, it provide bradycardia anti-tachycardia pacing (ATP). aim this study was compare appropriate inappropriate interventions, complications, disease-related adverse events mortality between HCM...
Endothelial dysfunction represents a key feature of the pathological process underlying micro and macro-vascular damage in Systemic Sclerosis (SSc). This study aims to improve knowledge physiopathology vascular SSc through assessment endothelial by Flow Mediated Dilation (FMD) serum levels circulating markers correlation macrovascular with clinical findings microvascular capillaroscopic patterns. 57 patients 37 healthy subjects were recruited. All included underwent radial artery FMD test...
Systemic Sclerosis (SSc), an intricate autoimmune disease causing tissue fibrosis, introduces cardiovascular complexities, notably pulmonary hypertension (PH), affecting both survival and quality of life. This study centers on evaluating echocardiographic parameters endothelial function using flow-mediated dilatation (FMD) in SSc patients, aiming to differentiate those with without arterial (PAH). The emphasis lies early detection, given the heightened vulnerability right ventricle (RV) presence PH.
Aims In chronic heart failure, changes of intra-thoracic impedance (Z0IT) may suggest impending pulmonary congestion; a similar result has been found by measuring trans-thoracic conductance (TFCTT = 1/Z0 1/kΩ). We assumed that relationship could exist between Z0IT and TFCTT. Methods collected 140 measurements from 70 patients carrying an implantable cardioverter-defibrillator/cardiac resynchronization device with the CareLink function (71 ± 9 years, New York Heart Association (NYHA) 2.4 0.9,...
Aims Optimization of inotropic treatment in worsening heart failure sometimes requires invasive hemodynamic assessment selected patients. Impedance cardiography (ICG) may be useful for a noninvasive evaluation. Methods ICG was performed 40 patients (69 ± 8 years; left ventricular ejection fraction 27.5 5.6%; New York Heart Association 3.18 0.34; Interagency Registry Mechanically Assisted Circulatory Support 5.48 0.96, before and after infusion Levosimendan (0.1–0.2 μg/kg per min up to 24 h)....