A5079313827- Phytoestrogen effects and research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Escherichia coli research studies
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Food Quality and Safety Studies
- Cerebrovascular and Carotid Artery Diseases
- Natural product bioactivities and synthesis
- Electrospun Nanofibers in Biomedical Applications
- Probiotics and Fermented Foods
- Cholesterol and Lipid Metabolism
- Curcumin's Biomedical Applications
- Food composition and properties
- Coronary Artery Anomalies
- Bacterial Genetics and Biotechnology
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
University of Palermo
2025
Gifu Prefectural Research Institute for Forests
2020-2022
Ibaraki University
2016
Hitachi (Japan)
2003-2016
Gifu Pharmaceutical University
2000-2015
Gifu University
2015
Nihon University
2004-2011
Oita University
2010
Nagoya University
2002-2010
National Institute of Biomedical Innovation, Health and Nutrition
2010
An equol-producing bacterium was newly isolated from the feces of healthy humans and its morphological biochemical properties were characterized. The cells obligate anaerobes. They non-sporulating, non-motile, gram-positive bacilliform bacteria with a pleomorphic morphology. strain catalase-positive, oxidase-, urease-, indole-negative. only other sugar utilized by glycerin. also degraded gelatin, but not esculin. It most closely related to Eggerthella hongkongensis HKU10, 93.3% 16S rDNA...
Abstract Recently, there has been noteworthy progress in the field of cardiac regeneration therapy. We previously reported that brown adipose tissue (BAT) contained progenitor cells were relevant to damaged myocardium. In this study, we found CD133-positive, but not c-Kit- or Sca-1-positive, BAT differentiated into cardiomyocytes (CMs) with a high frequency. Moreover, CD133+ tissue-derived (BATDCs) effectively induced bone marrow (BMCs) CMs. BMCs are considered have greatest potential as...
Abstract The hypolipidemic effects and bile acid‐binding properties of young persimmon ( Diospyros kaki ) fruit were examined. In an animal experiment, male C57BL/6.Cr mice n = 5) fed AIN‐76‐modified high fat diet supplemented with 2% or 5% (w/w) dried (YP) for 10 weeks. intake YP significantly enhanced fecal acid excretion lowered the concentration hepatic lipids plasma cholesterol. Analysis gene expression in liver tissue showed that up‐regulated sterol regulatory element‐binding protein‐2...
Bile acid-binding agents are known to lower blood cholesterol levels and have been clinically used for the treatment of hypercholesterolemia. We previously showed that tannin-rich fiber from young persimmon <i>(Diospyros kaki)</i> fruits had bile properties. In this study, we performed a randomized, double-blind, placebo-controlled trial investigate hypocholesterolemic effects in humans. The subjects (n = 40, plasma total 180–259 mg/dl) were divided into 3 groups ingested cookie...
Daidzein (DZN) is converted to equol (EQL) by intestinal bacteria. We previously reported that Eggerthella sp. YY7918, which found in human feces, an EQL-producing bacterium and analyzed its whole genomic sequence. three coding sequences (CDSs) this showed 99% similarity the enzymes of Lactococcus 20-92. These identified CDSs were designated eqlA, eqlB, eqlC thought encode daidzein reductase (DZNR), dihydrodaidzein (DHDR), tetrahydrodaidzein (THDR), respectively. genes cloned into pColdII....
Abstract Background The cut-off value for defining severe secondary tricuspid regurgitation (STR) using the planimetry of color Doppler three-dimensional echocardiography (3DE) vena contracta area (VCA) has been determined in previous studies based on its correlation with values effective regurgitant orifice (EROA), obtained proximal isovolumic surface (PISA) method, patients STR. However, association VCA outcomes not examined these studies. Purpose We sought to 1) identify 3DE associated an...
We examined the effect of okara on prevention obesity in mice. A modified AIN-76 diet with a high fat content (14.1% crude fat) was used as basal diet. Male ICR mice were fed ad libitum or dried okara-supplemented (10, 20, 40%) for 10 weeks. The intake dose-dependently suppressed development body weight and epididymal white adipose tissue (EWAT), prevented an increase plasma lipids, including total cholesterol, LDL non-esterified fatty acid. also steatosis liver. Real-time RT-PCR revealed...
Abstract The bile acid‐binding ability of a highly polymerized tannin (kaki‐tannin) extracted from dried‐young fruits persimmon ( Diospyros kaki ) was examined. kaki‐tannin composed mainly epicatechin, epigallocatechin, epicatechin‐3‐ O ‐gallate and epigallocatechin‐3‐ ‐gallate. Bile examined against cholic acid, glycocholic taurocholic acid deoxycholic in vitro , its effect on fecal excretion mice also Although the weaker than that cholestyramine, adsorbed all acids tested significantly...
ABSTRACT Eggerthella sp. strain YY7918 was isolated from the intestinal flora of a healthy human. It metabolizes daidzein (a soybean isoflavonoid) and produces S -equol, which has stronger estrogenic activities than daidzein. Here, we report finished annotated genomic sequence this organism.
The effect of young and mature persimmon fruits on lipid metabolism was investigated in a diet-induced murine obesity model. A commercially purchased high fat diet (Quick Fat, CLEA Japan) used as the basal diet. Dried powdered two breeds persimmon, Fuyu-kaki Hachiya-kaki, were added to at concentration 10%, respectively. Male C57BL/6 mice (n=4) divided into five groups fed or one persimmon-supplemented diets ad libitum for 14 weeks. Diets supplemented with both types fruit significantly...
Infectious diseases due to enterohemorrhagic Escherichia coli (EHEC) are characterized by diarrhea, hemorrhagic colitis and hemolytic uremic syndrome. The adherence of EHEC on intestinal epithelial cells is a first step for developing these diseases. In the present study, we examined whether O157:H7 adhere mice cause F-actin accumulation in following intragastric inoculation pathogen. Fecal shedding strain was observed ICR up 3 weeks. periods type III secretion system-related gene (espA...
A simple globobiosyl (Gb2) ceramide mimic carrying a monoalkyl chain (C18) was applied for monolayer Langmuir−Blodgett (L−B) technique to detect Shiga toxins (Stxs) by quartz crystal microbalance (QCM) method. The artificial glycolipid, synthesized from penta-O-acetyl-d-galactopyranose via conventional glycosidation pathway, developed at the air−water surface formation of film. Then, film transferred onto QCM cell modified with alkanethiols. Upon addition each Stx-1 and Stx-2, decrease...
We investigated the hypolipidemic effects of young persimmon fruit (YP) on apolipoprotein E-deficient C57BL/6.KOR-ApoEshl mice. These mice exhibited higher plasma cholesterols, except for high-density lipoprotein (HDL), and lower HDL cholesterol than C57BL/6.Cr that had same genetic background as Male (n=5) were fed a diet supplemented with dry YP, Hachiya-kaki, at concentration 5% (w/w) 10 weeks. YP treatment significantly lowered chylomicron, very low-density (VLDL) (LDL) triglyceride,...
Bacterial strain possessing both bacteriostatic and fungistatic activity (biocontrol activity) against pathogens of cyclamen (Cyclamen sp.) was isolated from the soil in Gifu Prefecture, Japan, characterized with respect to its taxonomic biocontrol properties. The sequence 16S rRNA gene, morphology, biochemistry, fatty acid composition demonstrated that it is a most closely related Alcaligenes faecalis subsp. LMG 1229T. isolate named A. AD15. AD15 produced hydroxylamine at maximum yields...
Shiga toxin (Stx) is one of the most critical factors in development hemolytic uremic syndrome and other systemic complications following enterohemorrhagic Escherichia coli (EHEC) infection. Substances neutralizing Stx by interfering with toxin-receptor binding have been explored as therapeutic candidates for EHEC In this study, we examined globotriaosyl (Gb3), galabiosyl (Gb2) galacto-trehalose, each which was synthetically conjugated a polyacrylamide backbone, Stxneutralizing activity....