A5072922238- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Nicotinic Acetylcholine Receptors Study
- Diabetes Treatment and Management
- Pharmacovigilance and Adverse Drug Reactions
- Cardiac Structural Anomalies and Repair
- Botulinum Toxin and Related Neurological Disorders
- Venous Thromboembolism Diagnosis and Management
- Parkinson's Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
- Tryptophan and brain disorders
- Diabetes Management and Research
- Heart Failure Treatment and Management
University of Catania
2023-2025
University of Ferrara
2021-2025
University College London
2025
St Bartholomew's Hospital
2025
Arcispedale Sant'Anna
2022-2024
May Institute
2022
Importance Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages no heart failure (HF) symptoms and a wide range of infiltration. Objective To characterize the clinical phenotype natural history asymptomatic patients ATTR Design, Setting, Participants This cohort study analyzed data all 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023. Inclusion criteria were infiltration, defined as an...
Introduction: Alzheimer’s disease (AD) is the most common neurodegenerative disorder affecting elderly population worldwide. Due to multifactorial nature of disease, involving impairment cholinergic neurotransmission and immune system, previous attempts find effective treatments have faced challenges. Methods: In such scenario, we attempted investigate effects alpha-glyceryl-phosphoryl-choline (α-GPC), a cholinomimetic molecule, on neuroinflammation memory outcome in triple transgenic mouse...
Alzheimer’s disease (AD), marked by cognitive impairment, predominantly affects the brain regions regulated cholinergic innervation, such as cerebral cortex and hippocampus. Cholinergic dysfunction, a key contributor to age-related decline, has spurred investigations into potential therapeutic interventions. We have previously shown that choline alphoscerate (α-GPC), neurotransmission-enhancing agent, protects from Aβ-mediated neurotoxicity. Herein, we investigated effects of α-GPC on...
Journal Article Corrected proof Specialist services for cardiomyopathy: quality care requires diagnostic accuracy Get access Anna Cantone, Cantone Barts Heart Centre, St. Bartholomew's Hospital, London, UKUniversity College Institute of Cardiovascular Science, Ferrara, Research Italy Search other works by this author on: Oxford Academic Google Scholar Saidi A Mohiddin, Mohiddin UKWilliam Harvey Institute, Queen Mary University UK Massimiliano Lorenzini Corresponding author: Email: [email...
About one in seven elderly patients with severe calcific aortic stenosis (AS) also have ATTR amyloid cardiomyopathy (AC-TTR). The reasons for this close association are not fully known, but the two entities only related by common epidemiology. For example, it is possible to hypothesize that an amyloidotic infiltration of valve, even partial, can act as a trigger development endothelial damage and subsequent calcification. Another hypothesis increased myocardial strain induced AS may locally...
The therapy of transthyretin (TTR)-related cardiac amyloidosis consists, on the one hand, prevention and management complications (supportive therapy) other treatments aimed at interrupting or slowing down production deposition fibrils (disease-modifying therapy). This definition includes drugs that act different phases amyloidogenesis: (i) silencing gene encoding TTR (small interfering RNA: patisiran, vutrisiran; antisense oligonucleotides: inotersen, eplontersen; new CRISPR Cas-9 drug...
Alzheimer's disease (AD) is the most common cause of dementia worldwide, characterized by accumulation amyloid-β protein and hyperphosphorylated tau in brain. Neuroinflammation, resulting from chronic activation brain-resident innate immune cells as well enhanced peripheral leukocyte access across blood-brain barrier, crucially affects AD progression. In this context, TNFSF10, a cytokine substantially expressed brain, has been shown to modulate both adaptive branches response AD-related...
Currently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. There is urgent need for a better understanding of how smoking influences antidiabetic treatment efficacy. The review underscores the role cigarette smoke, polycyclic aromatic hydrocarbons (PAHs), modulating metabolic pathways drugs, primarily through induction cytochrome P450 (CYP450) enzymes uridine diphosphate (UDP)-glucuronosyltransferases...
Parkinson's disease displays clinical heterogeneity, presenting with motor and non-motor symptoms. Heterogeneous phenotypes, named brain-first body-first, may reflect distinct α-synuclein pathology starting either in the central nervous system or periphery. The immune plays a prominent role peripheral pathology, misfolded being placed at intersection between neurodegeneration inflammation. Here, we characterized inflammatory profile immune-phenotype of blood mononuclear cells (PBMCs) from...
Background: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages no heart failure (HF) symptoms and a wide range of infiltration. Aim: The aim the study was to characterize natural history long-term outcomes patients ATTR HF symptoms. Methods: Data consecutive 12 international centres for amyloidosis (2008-2023) were analysed. Asymptomatic defined as absence diuretic therapy, monoclonal gammopathy evidence uptake on bone...
The diagnosis of myocardial infarction (MI) in the presence heart failure (HF) presents a clinical problem. While diagnostic algorithms using high-sensitivity cardiac troponin have been established for suspected MI, their accuracy patients with HF remains uncertain. This study aims to assess I (TnI) levels identifying acute MI among HF, focusing on baseline, absolute and relative TnI changes.
Introduction Cardiac amyloidosis typically causes restrictive cardiomyopathy, in which the impairment of diastolic function is dominant. Echocardiography provides prognostic information through some important parameters: left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). However, LVEF often remains preserved despite disease progression, GLS not routinely performed as it limited by suboptimal image quality. The stroke volume index (SVi) has already been shown to...
Cardiovascular disease (CVD) is a chronic condition driven by the complex interaction of different risk factors including genetics, lifestyle, environment, etc. which, differently from other pathologies, can be prevented. Treatment CVD has been inconceivably successful but now it seems that reached plateau suggesting prevention way forward. However, COVID-19 pandemic spotted all limits actual health system regarding territorial and, particularly, preventive medicine. To this end, recently,...