A5005052674- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Ocular Surface and Contact Lens
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- 3D Printing in Biomedical Research
- Dendrimers and Hyperbranched Polymers
- Bone Tissue Engineering Materials
- Supramolecular Self-Assembly in Materials
- Biopolymer Synthesis and Applications
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Synthesis and properties of polymers
- Microbial Metabolites in Food Biotechnology
- Surfactants and Colloidal Systems
- Nanocluster Synthesis and Applications
- Polymer Surface Interaction Studies
University of Palermo
2016-2025
National Research Council
2012-2021
Institute of Biophysics
2018
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2013-2017
Chiesi (France)
2015
National Academies of Sciences, Engineering, and Medicine
2014
Czech Academy of Sciences, Institute of Biophysics
2014
National Research Council
2011
Institute of Nanostructured Materials
2010
Instituto di Biofisica
2010
Carbon nanodots are known for their appealing optical properties, especially intense fluorescence tunable in the visible range. However, they often affected by considerable issues of and structural heterogeneity, which limit performance practical possibility applying these nanoparticles several fields. Here we developed a synthesis method capable producing unique variety carbon displaying an extremely high absorption strength (ε > 3 × 106 M(dot)−1 cm–1) quantum yield (73%). The homogeneity...
Folate-targeted gold nanorods (GNRs) are proposed as selective theranostic agents for osteosarcoma treatment. An amphiphilic polysaccharide based graft-copolymer (INU-LA-PEG-FA) and an amino derivative of the α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide functionalized with folic acid (PHEA-EDA-FA), have been synthesized to act coating GNRs. The obtained polymer-coated GNRs were characterized in terms size, shape, zeta potential, chemical composition, aqueous stability. They protected...
Here, mucus-penetrating nanoparticles (NPs) for pulmonary administration of ivacaftor in patients with cystic fibrosis (CF) were produced the dual aim enhancing delivery to airway epithelial cells, by rapid diffusion through mucus barrier, and at same time, promoting lung cellular uptake. Pegylated Tat-decorated fluorescent (FNPs) nanoprecipitation, starting from two synthetic copolymers, showed nanometric sizes (∼70 nm), a slightly negative ζ potential, high cytocompatibility toward human...
Very recent red-emissive carbon nanodots (CDs) have shown potential as near-infrared converting tools to produce local heat useful in cancer theranostics. Besides, CDs seem very appealing for clinical applications combining hyperthermia, imaging, and drug delivery a single platform capable of selectively targeting cells. However, still suffer from dramatic dot-to-dot variability issues such that rational design their structural, optical, chemical characteristics medical has been impossible...
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for potential treatment colorectal carcinoma. Graphene oxide, thanks to huge aromatic surface area, allows easily load high amount irinotecan (33.0% w/w) and confers system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that release antitumor drug is influenced both by pH external medium NIR irradiation process. In vitro biological studies,...
Among the relevant properties of graphene derivatives, their ability acting as an energy-converting device so to produce heat (i.e., thermoablation and hyperthermia) was more recently taken into account for treatment solid tumors. In this pioneering study, first time, in vitro RGO-induced hyperthermia assessed combined with stimuli-sensitive anticancer effect a biotinylated inulin-doxorubicin conjugate (CJ-PEGBT), hence, getting nanosystem endowed synergic effects high specificity. CJ-PEGBT...
INU-ceramide and INU-ceramide-PEG<sub>2000</sub>graft copolymers form micelles able to deliver the anticancer drug doxorubicin with a preferential cytotoxic activity<italic>versus</italic>cancer cells.
Preferential uptake by cancer cells of PEG-inulin coated gold nanoparticles loaded with the drug doxorubicin.
Carbon nanodots (CDs) are a new class of carbon-based nanoparticles endowed with photoluminescence, high specific surface area, and good photothermal conversion, which have spearheaded many breakthroughs in medicine, especially drug delivery cancer theranostics. However, the tight control their structural, optical, biological properties synthesis scale-up been very difficult so far. Here, we report for first time an efficient protocol one-step decagram-scale quantities N,S-doped CDs narrow...
Ferulic acid (FA), a phenolic compound with significant antioxidant activity in Alzheimers disease, was entrapped into several solid lipid nanoparticles (SLN and NLC) by using the microemulsion technique. Stable SLN NLC formulations having mean size ranging between 94-140 nm high zeta potential were obtained. The sample obtained as matrix Compritol 888 ATO chosen for further characterization because, among these particles, showed Loading Capacity (LC%) best characteristics terms of size,...
Polymeric micelles obtained by self-assembling of amphiphilic hyaluronic acid (HA) graft copolymers have been prepared and characterized. In particular, has grafted to polylactic (PLA) polyethylenglycol chains (PEG), then the able form in aqueous medium chosen entrap antitumoral drug Doxorubicin. The critical aggregation concentration HA-g-PLA or HA-g-PLA-g-PEG determined using pyrene as a fluorescent probe, whereas their shape size evaluated light scattering measurements, scanning...