A5006758699- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Advanced Polymer Synthesis and Characterization
- Biopolymer Synthesis and Applications
- Graphene and Nanomaterials Applications
- Polysaccharides Composition and Applications
- Synthesis and properties of polymers
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Polysaccharides and Plant Cell Walls
- Corneal Surgery and Treatments
- Antimicrobial agents and applications
- Microbial Metabolites in Food Biotechnology
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
University of Palermo
2016-2025
KTH Royal Institute of Technology
2023
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2021
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2011-2016
National Research Council
2013-2015
Chiesi (France)
2015
Istituto di Farmacologia Traslazionale
2001
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for potential treatment colorectal carcinoma. Graphene oxide, thanks to huge aromatic surface area, allows easily load high amount irinotecan (33.0% w/w) and confers system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that release antitumor drug is influenced both by pH external medium NIR irradiation process. In vitro biological studies,...
In this study, hydrogels were produced using a Schiff base reaction between two hyaluronic acid derivatives: one containing aldehyde groups (HA-Ald) and the other holding diethylenetriamine with terminal amino (HA-DETA). The DETA portion promotes in situ growth, complexation, stabilization of silver nanoparticles (AgNPs), eliminating need for external reducing agents. HA-DETA HA-Ald leads to formation imine bonds, which results dynamically pH-responsive cross-linking. While capping ability...
A novel pH-sensitive and biodegradable composite hydrogel, based on a methacrylated succinic derivative of dextran, named Dex-MA-SA, α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA), PHM-SA, was produced by photocross-linking. The goal to obtain colon-specific drug delivery system, exploiting both the behavior degradability. hydrogel prepared with suitable ratio between polysaccharide polyaminoacid characterized regarding its swelling in gastrointestinal simulated conditions, chemical...
A series of four different low molecular weight gellan gum products was obtained by alkaline hydrolysis with the aim to investigate impact on rheological properties polysaccharide aqueous dispersions and physicochemical characteristics derived ionotropic crosslinked hydrogels. In particular, thermo-rheological analysis conducted study influence thermogelation typical native while strain sweep experiments were establish if dispersion shows a viscoelastic behavior. The effect Ca2+ hydrogels...
Blood-brain barrier (BBB) is a selective and dynamic structure, formed by endothelial cells, that allows the passage of substances from blood to CNS vice versa.During brain development, capillary cells (BCECs) gradually acquire ability form barrier, it known astrocytes [1] as well neurons [2] play an inductive role in this process.BCECs are joined together intercellular tight junctions (TJs) responsible for acquisition
Polymeric micelles obtained by self-assembling of amphiphilic hyaluronic acid (HA) graft copolymers have been prepared and characterized. In particular, has grafted to polylactic (PLA) polyethylenglycol chains (PEG), then the able form in aqueous medium chosen entrap antitumoral drug Doxorubicin. The critical aggregation concentration HA-g-PLA or HA-g-PLA-g-PEG determined using pyrene as a fluorescent probe, whereas their shape size evaluated light scattering measurements, scanning...
Abstract The aim of this work is to prepare hyaluronic acid‐based micelles as a platform load corticosteroid drugs and improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives acid (HA) are synthesized using different amounts hexadecylamine (C 16 ‐NH 2 ). HAC , b, c able form by cosolvent evaporation method entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). b show best results in terms drug loading particle size....