A5038274094- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Medical Imaging and Pathology Studies
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Eosinophilic Disorders and Syndromes
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Cardiac tumors and thrombi
- Long-Term Effects of COVID-19
Medical University of Vienna
2018-2025
University College London
2023-2024
British Heart Foundation
2024
St Bartholomew's Hospital
2023-2024
Barts Health NHS Trust
2023-2024
Delft University of Technology
2024
Vienna General Hospital
2024
Arbeitsgemeinschaft für Klinische Ernährung
2023
Harvard University
2020
Massachusetts General Hospital
2020
Older patients with severe aortic stenosis (AS) are increasingly identified as having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse outcomes or results in futility of transcatheter valve replacement (TAVR).This study clinical characteristics and compared lone AS.Patients who were referred for TAVR at 3 international sites underwent blinded research core laboratory 99mtechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) bone scintigraphy (Perugini grade...
Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive cardiomyopathy. The clinical course varies among individuals and there are no established measures to assess disease progression. goal of this study was the prognostic importance an increase in N-terminal pro–B-type natriuretic peptide (NT-proBNP) outpatient diuretic intensification (ODI) as markers progression large cohort patients with ATTR-CA. We evaluated landmark survival analysis based on worsening NT-proBNP requirement for...
Abstract Aims Concomitant cardiac amyloidosis (CA) in severe aortic stenosis (AS) is difficult to recognize, since both conditions are associated with concentric left ventricular thickening. We aimed assess type, frequency, screening parameters, and prognostic implications of CA AS. Methods results A total 191 consecutive AS patients (81.2 ± 7.4 years; 50.3% female) scheduled for transcatheter valve replacement (TAVR) were prospectively enrolled. Overall, 81.7% underwent complete assessment...
Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive and ultimately fatal cardiomyopathy. Biomarkers reflecting multiorgan dysfunction are of increasing importance in patients with heart failure; however, their significance ATTR-CA remains largely unknown. The aims this study were to characterize the multifaceted nature using blood biomarkers assess association between prognosis. This retrospective cohort 2566 consecutive diagnosed 2007 2023. Anemia (39%), high urea (52%),...
Importance Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages no heart failure (HF) symptoms and a wide range of infiltration. Objective To characterize the clinical phenotype natural history asymptomatic patients ATTR Design, Setting, Participants This cohort study analyzed data all 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023. Inclusion criteria were infiltration, defined as an...
Background: This study assessed the prognostic value of submaximal cardiopulmonary exercise testing (CPET) in cardiac amyloidosis and explored CPET as an alternative to 6-min walk test (6MWT).
Abstract Purpose Advancements of deep learning in medical imaging are often constrained by the limited availability large, annotated datasets, resulting underperforming models when deployed under real-world conditions. This study investigated a generative artificial intelligence (AI) approach to create synthetic images taking example bone scintigraphy scans, increase data diversity small-scale datasets for more effective model training and improved generalization. Methods We trained on 99m...
Abstract Background Cardiac amyloidosis (CA) is a severe condition characterized by amyloid fibril deposition in the myocardium, leading to restrictive cardiomyopathy and heart failure. Differentiating between subtypes crucial due distinct treatment strategies. The individual conventional diagnostic methods lack accuracy needed for effective subtype identification. This study aimed evaluate efficacy of combining 11 C-PiB PET/CT 99m Tc-DPD scintigraphy detecting CA distinguishing its main...
Background In heart failure with preserved ejection fraction (HFpEF), echocardiographic studies suggest that global longitudinal strain (GLS) has an impact on survival. Feature-tracking cardiovascular MRI also allows for analysis; however, to the knowledge of authors, little is known about its prognostic value and whether it reflects severity diffuse fibrosis, as assessed by T1 mapping. Purpose To investigate association between myocardial at extracellular volume mapping outcome in...
Tricuspid regurgitation secondary to heart failure (HF) is common with considerable impact on survival and hospitalization rates. Currently, insights into epidemiology, impact, treatment of tricuspid (sTR) across the entire HF spectrum are lacking, yet necessary for healthcare decision-making.
The prevalence and significance of cardiac amyloidosis have been considerably underestimated in the past; however, number patients diagnosed with has increased significantly recently due to growing awareness disease, improved diagnostic capabilities demographic trends. Specific therapies that improve patient prognosis become available for certain types amyloidosis. Thus, earliest possible referral suspicion an experienced center is crucial ensure rapid diagnosis, early initiation treatment,...
The 2021 European Society of Cardiology (ESC) screening recommendations for individuals carrying a pathogenic transthyretin amyloidosis variant (ATTRv) are based on expert opinion. We aimed to (i) determine the penetrance ATTRv cardiomyopathy (ATTRv-CM) at baseline; (ii) examine value serial evaluation; and (iii) establish yield first-line diagnostic tests (i.e. electrocardiogram, echocardiogram, laboratory tests) as per ESC position statement.
The prevalence of cardiac amyloidosis (CA) in the general population and associated prognostic implications remain poorly understood. We aimed to identify CA outcomes bone scintigraphy referrals. <b>Methods:</b> Consecutive all-comers undergoing <sup>99m</sup>Tc-3,3-diphosphono-1,2-propanodicarboxylic-acid (<sup>99m</sup>Tc-DPD) between 2010 2020 were included. Perugini grade 1 was defined as low-grade uptake 2 or 3 confirmed CA. All-cause mortality, cardiovascular death, heart failure...
Background: Dual pathology of severe aortic stenosis (AS) and transthyretin cardiac amyloidosis (ATTR) is increasingly recognized. Evolution symptoms, biomarkers, myocardial mechanics in AS-ATTR following valve replacement unknown. We aimed to characterize reverse remodeling compared with lone AS. Methods: Consecutive patients referred for transcatheter (TAVR) underwent ATTR screening by blinded 99mTc-DPD bone scintigraphy (Perugini Grade-0 negative, 1–3 positive) before intervention. was...
Abstract Aims The pathophysiological hallmark of cardiac amyloidosis (CA) is the deposition amyloid within myocardium. Consequently, extracellular volume (ECV) affected patients increases. However, studies on ECV progression over time are lacking. We aimed to investigate and its prognostic impact in CA patients. Methods results Serial magnetic resonance (CMR) examinations, including quantification, were performed consecutive Between 2012 2021, 103 underwent baseline follow-up CMR,...
Novel ribonucleic acid interference (RNAi) therapeutics such as patisiran and inotersen have been shown to benefit neurologic disease course quality of life in patients with hereditary transthyretin amyloidosis (ATTRv). We aimed determine the impact RNAi on myocardial amyloid load using quantitative single photon emission computed tomography/computed tomography (SPECT/CT) imaging ATTRv-related cardiomyopathy (ATTRv-CM). furthermore compared them wild-type ATTR-CM (ATTRwt-CM) treated tafamidis.
Abstract Objective Epicardial adipose tissue (EAT) quantity is associated with poor cardiovascular outcomes. However, the quality of EAT may be incremental prognostic value. Cardiac magnetic resonance (CMR) gold standard for characterization but has never been applied assessment. We aimed to investigate measured on CMR T1 mapping as a predictor outcomes in an all‐comer cohort. Methods investigated association area and times (EAT‐T1) composite endpoint nonfatal myocardial infarction, heart...
Cardiac amyloidosis (CA) leads to signs and symptoms of heart failure (HF). The mechanisms biventricular dysfunction their impact on outcome in subtypes CA are poorly understood. Our aim was compare right ventricular (RV) left (LV) parameters patients with light chain (AL) wild-type transthyretin (ATTRw) evaluate ability predict cardiac outcome.We included into a prospective registry. Baseline assessment 2D speckle tracking imaging parameters. Patients were followed-up regular intervals....
Mitral regurgitation (MR) and cardiac amyloidosis (CA) both primarily affect older patients. Data on coexistence prognostic implications of MR CA are currently lacking. This study sought to identify the prevalence, clinical characteristics, outcomes compared with lone MR. Consecutive patients undergoing transcatheter edge-to-edge repair (TEER) for at 2 sites were screened concomitant using a multiparametric approach including core laboratory 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid...
Abstract Aims Transthyretin cardiac amyloidosis (ATTR‐CA) is stratified into prognostic categories using the National Amyloidosis Centre (NAC) staging system. The aims of this study were to further expand existing NAC system incorporate an additional disease stage that would identify patients at high risk early mortality. Methods and results traditional (stage 1: N‐terminal pro‐B‐type natriuretic peptide [NT‐proBNP] ≤3000 ng/L estimated glomerular filtration rate [eGFR] ≥45 ml/min; 3:...