A5069272529- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Imaging and Diagnostics
- Tryptophan and brain disorders
- Cardiovascular Function and Risk Factors
- Gut microbiota and health
- Cardiac Valve Diseases and Treatments
- Gastrointestinal motility and disorders
- Cardiomyopathy and Myosin Studies
- Medical Imaging and Pathology Studies
- Obesity, Physical Activity, Diet
- Parathyroid Disorders and Treatments
- Stress Responses and Cortisol
- Probiotics and Fermented Foods
- Diabetes Management and Research
- Cardiovascular Effects of Exercise
- Immune Response and Inflammation
- Library Science and Administration
- Cardiovascular and exercise physiology
- Infective Endocarditis Diagnosis and Management
- Diabetes and associated disorders
- Orthopedic Infections and Treatments
- Web and Library Services
- Advanced MRI Techniques and Applications
- Child Development and Digital Technology
- Education, Sociology, Communication Studies
St Bartholomew's Hospital
2016-2024
Barts Health NHS Trust
2018-2024
King's College Hospital
2024
King's College Hospital NHS Foundation Trust
2024
University Hospital Limerick
2014-2023
University of Limerick
2019-2023
Mahasarakham University
2023
University College London
2016-2022
British Heart Foundation
2018-2021
University College Hospital
2021
Host defence against infection requires a range of innate and adaptive immune responses that may lead to tissue damage. Such immune-mediated pathologies can be controlled with appropriate T regulatory (Treg) activity. The aim the present study was determine influence gut microbiota composition on Treg cellular activity NF-κB activation associated infection. Mice consumed commensal microbe Bifidobacterium infantis 35624 followed by Salmonella typhimurium or injection LPS. In vivo quantified...
Older patients with severe aortic stenosis (AS) are increasingly identified as having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse outcomes or results in futility of transcatheter valve replacement (TAVR).This study clinical characteristics and compared lone AS.Patients who were referred for TAVR at 3 international sites underwent blinded research core laboratory 99mtechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) bone scintigraphy (Perugini grade...
Background— Calcific aortic stenosis (cAS) affects 3% of individuals aged >75 years, leading to heart failure and death unless the valve is replaced. Wild-type transthyretin cardiac amyloid also a disorder ageing individuals. Prevalence clinical significance dual pathology are unknown. This study explored prevalence wild-type in cAS by myocardial biopsy, its imaging phenotype prognostic significance. Methods Results— A total 146 patients with severe AS requiring surgical replacement...
Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter valve implantation (TAVI). We hypothesized that dual and cardiac amyloid pathology (AS-amyloid) would have different baseline characteristics, periprocedural mortality outcomes.Patients aged ≥75 severe AS TAVI at two sites underwent blinded bone scintigraphy prior to intervention (Perugini Grade 0 negative, 1-3 increasingly positive). Baseline assessment included echocardiography,...
Irritable bowel syndrome (IBS) is a functional disorder that associated with number of extra-intestinal co-morbidities and pro-inflammatory profile. This study was designed to examine the cytokine profile among group IBS patients fibromyalgia, premenstrual dysmorphic disorder, chronic fatigue syndrome.In all, 100 female these co-morbidities, 21 subjects without co-morbidity ("pure" IBS; Rome II), 54 age-matched controls took part in study. Blood drawn for measurement plasma cytokines...
The purpose of this study was to validate computed tomography measured ECV (ECVCT) as part routine evaluation for the detection cardiac amyloid in patients with aortic stenosis (AS)-amyloid. AS-amyloid affects 1 7 elderly referred transcatheter valve replacement (TAVR). Bone scintigraphy exclusion a plasma cell dyscrasia can diagnose transthyretin-related noninvasively, which novel treatments are emerging. Amyloid interstitial expansion increases myocardial extracellular volume (ECV)....
To assess whether single-photon emission computed tomography (SPECT/CT) quantification of bone scintigraphy would improve diagnostic accuracy and offer a means quantifying amyloid burden.Transthyretin-related cardiac amyloidosis is common can be diagnosed noninvasively using scintigraphy; interpretation, however, relies on planar images. SPECT/CT imaging offers 3-dimensional visualization.This was single-center, retrospective analysis 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD)...
Abstract Irritable bowel syndrome (IBS) has been linked with abnormal serotonin functioning and immune activation. Tryptophan forms the substrate for biosynthesis, but it can alternatively be catabolized to kynurenine (Kyn) by enzyme indoleamine 2,3‐dioxygenase (IDO), main inducer of which is interferon‐gamma. The primary aim this study was test hypothesis that IBS associated increased tryptophan (Trp) catabolism along Kyn pathway due IFN‐γ levels. Plasma Kyn, Trp levels were measured in 41...
Resident host microflora condition and prime the immune system. However, systemic mucosal responses to bacteria may be divergent. Our aim was compare, in vitro, cytokine production by human mononuclear dendritic cells (DCs) from mesenteric lymph nodes (MLNs) peripheral blood (PBMCs) defined microbial stimuli. Mononuclear DCs isolated MLN (n = 10) 12) of patients with active colitis were incubated vitro probiotic Lactobacillus salivarius UCC118 or Bifidobacterium infantis 35624 pathogenic...
Abstract The kynurenine pathway of tryptophan degradation may serve to integrate disparate abnormalities heretofore identified in research aiming elucidate the complex aetiopathogenesis psychotic disorders. Post-mortem brain tissue studies have reported elevated and kynurenic acid frontal cortex upregulation first step anterior cingulate individuals with schizophrenia. In this study, we examined activity by measuring breakdown, a number metabolites interferon gamma (IFN-γ), which is...
The lifetime prevalence of major depression is twice as high in females males. Depression known to increase at periods where there are changes gonadal hormones. We examined pro- and anti-inflammatory cytokine levels during the normal menstrual cycle healthy compared similar time points males.Plasma concentrations interleukin (IL)-4, IL-6, IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) soluble IL-6 receptor (sIL-6R) were measured with enzyme-linked immunosorbent assays ovulatory also...
BACKGROUND: Extracellular volume fraction (ECV) is a marker for myocardial fibrosis and infiltration, can be quantified using cardiac computed tomography (ECV CT ), has prognostic utility in several diseases. This study aims to map out regional differences ECV obtain greater insights into the pathophysiological mechanisms of expansion its clinical implications. METHODS: Three prospective cohorts were included: patients with aortic stenosis (AS) coexisting AS transthyretin amyloidosis...
There is evidence to indicate that peripheral glucocorticoid receptor (GR) function reduced in major depression, and a possible molecular explanation for this the impact of raised pro-inflammatory cytokines. The topical steroid vasoconstriction assay provides convenient probe GR function. present study sought assess sensitivity GRs antidepressant-resistant depressives investigate association between circulating plasma cytokines.Nineteen together with age- sex-matched healthy controls...