A5026381447- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Muscle Physiology and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital heart defects research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Valve Diseases and Treatments
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Renin-Angiotensin System Studies
- Streptococcal Infections and Treatments
- Cardiac Fibrosis and Remodeling
Johns Hopkins University
2012-2023
Gentofte Hospital
2012-2018
Johns Hopkins Medicine
2013-2018
Johns Hopkins Hospital
2011-2014
Roskilde Sygehus
2010
Background Hypertrophic cardiomyopathy ( HCM ) is a common inherited cardiac disease characterized by varying degrees of left ventricular outflow tract obstruction. In large cohort, we compare the outcomes among 3 different hemodynamic groups. Methods and Results We prospectively enrolled patients fulfilling standard diagnostic criteria for from January 2005 to June 2015. Detailed phenotypic characterization, including peak pressure gradients at rest after provocation, was measured...
Background. The NOVA score is a recently developed diagnostic tool used to identify patients with increased risk of infective endocarditis (IE) among Enterococcus faecalis bacteremia. We aimed validate the and factors for IE. Methods. From 1 January 2010 31 December 2013, we included 647 consecutive E. was in slightly adapted form; 2/2 positive blood cultures resulted 5 points, unknown origin infection 4 prior valve disease 2 heart murmur point. Results. IE diagnosed 78 (12%). Monomicrobial...
Hypertrophic cardiomyopathy (HCM) stems from mutations in sarcomeric proteins that elicit distinct biophysical sequelae, which turn may yield radically different intracellular signaling and molecular pathologic profiles. These events remain largely unaddressed by clinical trials have selected patients based on HCM diagnosis, irrespective of genotype. In this study, we determined how two mouse models differ, with respect to cellular/mitochondrial function biosignatures, at an early stage...
Left ventricular hypertrophy (LVH) is an adaptive response to physiological or pathological stimuli, and distinguishing between the two has obvious clinical implications. However, asymmetric septal preserved cardiac function are noted in early stages both cases. We characterized anatomic functional changes a mouse model of stress using serial echocardiography-based morphometry tissue velocity imaging. Weight-matched CF-1 male mice were separated into Controls ( n = 10), treadmill Exercise 1...
To investigate whether hypertrophic cardiomyopathy (HCM) patients with late gadolinium enhancement (LGE) confined to the right ventricular insertion points (RVIP) differ phenotypically from without LGE or intramural in left ventricle (LV). Sixty-two HCM underwent cardiac magnetic resonance for quantification of (% LV mass) and were classified as group (i) no-LGE (n = 18), (ii) LGE-RVIP 19), (iii) 25). All also vasodilator N-13 ammonia PET quantify myocardial blood flow (MBF) reserve (MFR),...
Objectives Invasive measurements of intracardiac hemodynamics in animal models have allowed important advances the understanding cardiac disease. Currently they are performed either through a carotid arteriotomy or via thoracotomy and apical insertion. Both these techniques disadvantages not conducive to repeated measurements. Therefore, purpose this study was develop new technique for measuring hemodynamics. Methods In 13 male rats, hemodynamic were using echocardiographically guided...
Background Echocardiography (ECHO) i su sed for diagnosis and management of hypertrophic cardiomyopathy (HCM). Morphologic is based on the presence myocardial thickness >15mm in adults or a septum to posterior wall ratio >1.5. Septal (WT) >30 mm one several high risk features that are used guide decision prophylactic implantable cardioverter-defibrillator (ICD) placement. Cardiac magnetic resonance imaging (CMR) offers improved contrast resolution over ECHO precisely defines WT HCM.CMR...
Hypertensive response to exercise (HRE) is observed in patients with hypertrophic cardiomyopathy (HCM) normal resting blood pressure (BP). However, the prevalence or prognostic implications of HRE HCM remain unclear.In this study, normotensive subjects were enrolled. was defined as systolic BP > 210 mmHg men >190 women, diastolic 90 mmHg, an increase 10 during treadmill exercise. All participants followed for subsequent development hypertension, atrial fibrillation (AF), heart failure (HF),...