A5014526717- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- NF-κB Signaling Pathways
- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Bone health and treatments
- Congenital Heart Disease Studies
- RNA modifications and cancer
- Oral Health Pathology and Treatment
- Aortic Disease and Treatment Approaches
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Periodontal Regeneration and Treatments
- Child Nutrition and Water Access
- Tracheal and airway disorders
- Orthodontics and Dentofacial Orthopedics
- Pregnancy and Medication Impact
- Infant Nutrition and Health
China Medical University
2015-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Sheng Jing Hospital
2024
Second Affiliated Hospital of Zhejiang University
2009-2023
Southern Medical University
2021-2023
Zhejiang University
2013-2023
Johns Hopkins Medicine
2013-2016
Johns Hopkins University
2013-2016
Johns Hopkins Hospital
2014
Background: A T‐helper 17 (Th17)/regulatory T (Treg) imbalance has been suggested recently to play a role in the development of periodontitis. All‐ trans retinoic acid (ATRA) reported modulate Th17/Treg imbalances some diseases. However, effect ATRA on periodontitis remains unknown. This study observes modulation experimental Methods: Experimental was induced mice by oral infection with Porphyromonas gingivalis ( P. ). orally administered every other day. Alveolar bone resorption (ABR)...
Porphyromonas gingivalis is one of the oral microorganisms associated with human chronic periodontitis. The purpose this study to determine role receptor activator nuclear factor-κB ligand (RANKL) in P. infection-associated periodontal bone resorption. Inbred female Rowett rats were infected orally on four consecutive days (days 0 3) 1 × 10(9) bacteria (strain ATCC 33277). Separate groups also received an injection anti-RANKL antibody, osteoprotegerin fusion protein (OPG-Fc), or a control...
Abstract Host immune responses play a key role in promoting bone resorption periodontitis via receptor activator of NF-κB ligand (RANKL)–dependent osteoclastogenesis. Both membrane-bound RANKL (mRANKL) expressed on lymphocytes and soluble (sRANKL) are found periodontal lesions. However, the underlying mechanism cellular source sRANKL release its biological unclear. TNF-α–converting enzyme (TACE) is reported to cleave following: 1) precursor TNF-α with mature, 2) mRANKL sRANKL. lesion,...
Gestational Diabetes Mellitus (GDM) has an effect on the health of pregnant women and fetuses. Procyanidins (PA) is a flavonoid with anti-diabetic activity, but its effects mechanisms GDM have not been defined. Herein, we studied further functions PA insulin resistance (IR) in mice, as well postpartum offspring mice. mice model was built by feeding high-fat-high-sucrose diet, intervention (27.8 mg/kg/d) performed from 4 weeks before pregnancy to delivery. Intestinal flora deficient (IFD)...
Patients with ischemic heart disease are associated poor prognosis, and their number has increased globally. Therefore, biomarkers that could predict post-acute myocardial infarction (AMI) failure (HF) would be helpful to guide appropriate treatment. Based on the diagnosis admission results of echocardiogram performed 1 year after discharge, current study recruited 54 patients post-AMI HF, 59 non-HF, healthy controls. Eight candidate microRNAs (miRs) were screened through real-time...
ABSTRACT Activated T and B lymphocytes in periodontal disease lesions express receptor activator of NF-κB ligand (RANKL), which induces osteoclastic bone resorption. The objective this study was to evaluate the effects anti-RANKL antibody on resorption vitro vivo. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) A. lipopolysaccharide (LPS) were injected into 3 palatal gingival sites, Omp29-specific clone cells transferred tail veins rats. Rabbit IgG or F(ab′) 2...
Introduction: We investigated receptor activator of nuclear factor‐κB ligand (RANKL) expression by B lymphocytes during early and late aspects the immune response to Aggregatibacter actinomycetemcomitans , a gram‐negative, anaerobic bacterium associated with aggressive periodontal disease. Methods: Expression messenger RNA transcripts (tumor necrosis factor‐α, Toll‐like receptors 4 9, interleukins 10, RANKL) involved in (1‐day) (10‐day) responses cultured rat splenocytes was examined reverse...
Guided by electro-chemo-thermal simulations, the thermal tolerance, conductance, and overheating-response properties were rationally coupled in a separator for safe lithium batteries.
Periodontitis is the second most common oral disease affecting tooth-supporting structures. The tissue damage mainly initiated by excessive secretion of proinflammatory cytokines immune cells. Macrophages are a type antigen-presenting cells that influence adaptive immunity function. We used unique set cytokines, i.e., combination IL-4, IL-13, and IL-10, to stimulate macrophages into subset M2 polarization express much higher levels ARG-1, CD206, PDL-2 genes. cells' anti-inflammatory...
Background and Objective Periodontitis is a bacteria‐induced disease that often leads to alveolar bone damage. Its mechanisms were considered be complicated, involving an imbalance of the formation resorption bone. We sought disclose antibody‐independent function B cells during periodontitis. Material Methods Production receptor activator for nuclear factor‐κB ligand (RANKL) by total lymphocytes or sorted B‐cell subsets in gingiva from healthy experimental periodontitis animals was examined...