A5061965999- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Bacterial Identification and Susceptibility Testing
- Otolaryngology and Infectious Diseases
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Infectious Aortic and Vascular Conditions
- Actinomycetales infections and treatment
- Orthopedic Infections and Treatments
- Viral Infections and Immunology Research
- Diabetes and associated disorders
- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Atrial Fibrillation Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Diphtheria, Corynebacterium, and Tetanus
- Sepsis Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Treatment of Major Depression
- Diverse Scientific Research Studies
- Infectious Disease Case Reports and Treatments
- Endoplasmic Reticulum Stress and Disease
Gentofte Hospital
2015-2024
Technical University of Denmark
2024
Statistics Sweden
2024
Lund University
2024
Universitat de Barcelona
2019-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2023
Bispebjerg Hospital
2018-2023
Hospital Clínic de Barcelona
2022-2023
University of Copenhagen
1987-2022
Frederiksberg Hospital
2018
Background: Streptococci frequently cause infective endocarditis (IE), yet the prevalence of IE in patients with bloodstream infections (BSIs) caused by different streptococcal species is unknown. We aimed to investigate at level BSIs. Methods: investigated all BSIs, from 2008 2017, Capital Region Denmark. Data were crosslinked Danish nationwide registries for identification concomitant hospitalization IE. In a multivariable logistic regression analysis, we risk according adjusted age, sex,...
BACKGROUND: Left atrial (LA) speckle tracking provides detailed information on function. Its utility for predicting subclinical fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring. METHODS: This was an echocardiographic substudy of the LOOP study, where elderly at risk stroke were randomized receive a loop recorder (Reveal LINQ) or control. Participants who received included in...
Because of the nephrotoxic effects aminoglycosides, Danish guidelines on infective endocarditis were changed in January 2007, reducing gentamicin treatment enterococcal from 4 to 6 weeks only 2 weeks. In this pilot study, we compare outcomes patients with Enterococcus faecalis treated years before and after endorsement these new recommendations.A total 84 consecutive admitted definite left-sided E period 2002 2011 enrolled. Forty-one 43 1, 2007. There no significant differences baseline...
Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have conducted on selected patient cohorts, yet unselected data are sparse. We aimed investigate prevalence IE BSIs bacteria typically associated IE.By crosslinking nationwide registries from 2010 2017, we identified IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative...
Little is known about the mortality for patients with infective endocarditis (IE) on a nationwide scale, and previous studies have been conducted in selected cohorts from tertiary centers. We aimed to investigate temporal trends using Danish registries.We identified first-time IE between 1999-2018, they were grouped by calendar periods (1999-2003, 2004-2008, 2009-2013, 2014-2018). One-year was estimated Kaplan-Meier estimates. For periods, odds ratios (ORs) hazard (HRs) computed...
Background. The NOVA score is a recently developed diagnostic tool used to identify patients with increased risk of infective endocarditis (IE) among Enterococcus faecalis bacteremia. We aimed validate the and factors for IE. Methods. From 1 January 2010 31 December 2013, we included 647 consecutive E. was in slightly adapted form; 2/2 positive blood cultures resulted 5 points, unknown origin infection 4 prior valve disease 2 heart murmur point. Results. IE diagnosed 78 (12%). Monomicrobial...
It is known that patients surviving infective endocarditis have a poor long-term prognosis; however, few studies addressed the causes of death in initial hospitalization.Using Danish administrative registries, we identified admitted to hospital with 1st time period from January 1996 December 2014, who were alive at discharge. The study population was categorized into (i) undergoing medical therapy only and (ii) surgical treatment. We examined cardiovascular non-cardiovascular death. Using...
The modified Duke criteria requires that Enterococcus faecalis bacteremia must be both community-acquired and without known focus in order to considered a microbiological "Major" diagnostic criterion the diagnosis of infective endocarditis. We believe should updated regard E. as "typical" endocarditis bacterium is currently case, for example, viridans group streptococci Staphylococcus aureus. Using data from prospective study 344 patients with evaluated echocardiography, we demonstrate...
Infective endocarditis (IE) is associated with high mortality. Surgery may improve survival and reduce complications, but the balance between benefit harm difficult be closely related to age type of surgical intervention. We aimed examine how left-sided intervention modified mortality in patients undergoing surgery for IE.By crosslinking nationwide Danish registries we identified first-time IE treatment 2000-2017. Patients were grouped by < 60 years, 60-75 ≥ 75 years. Multivariable adjusted...
Abstract Background Traditional treatment of methicillin-susceptible Staphylococcus aureus (MSSA) native valve endocarditis is based on cloxacillin/cefazolin monotherapy. Antibiotics with high activity against MSSA such as ceftaroline and daptomycin have been marketed last years, but there are no clinical trials evaluating them monotherapy or combination therapy in patients endocarditis. Objectives To compare the efficacy cloxacillin, monotherapies combinations beta-lactams a rabbit model...
Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some are more likely to severe infections than others. S. bloodstream from 120 patients with definite infective endocarditis and 121 bacteraemia without underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome k-mer based analysis. Core analyses found no either two...
Abstract The accuracy of contemporary risk scores in predicting perioperative mortality infective endocarditis (IE) remains controversial. aim is to evaluate the performance existent for cardiovascular surgery IE and impact on operability at high-risk thresholds. A single-center retrospective review adult patients diagnosed with acute left-sided undergoing from May 2014 August 2019 ( n = 142) was done. Individualized calculation obtained according available scores: EuroScore I II, PALSUSE,...
Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions multifaceted involves complex interactions metabolic, inflammatory, genetic factors. Here we assess the underlying structural molecular processes focusing on immunological phase MASH in nonobese inflammation fibrosis (NIF) mouse model compare it to human disease as well other murine models. Histopathology...
The role of host genetic variation in the development complicated Staphylococcus aureus bacteremia (SAB) is poorly understood. We used whole exome sequencing (WES) to examine cumulative effect coding variants each gene on risk SAB a discovery sample 168 cases (84 and 84 uncomplicated, frequency matched by age, sex, bacterial clonal complex [CC]), then evaluated most significantly associated genes replication 240 (122 118 for CC) using targeted sequence capture. In sample, gene-based analysis...
Abstract Background Staphylococcus aureus bacteremia (SAB) can be community-acquired or healthcare-associated, and prior small studies have suggested that this mode of acquisition impacts the subsequent prevalence infective endocarditis (IE) patient outcomes. Methods First-time SAB was identified from 2010 to 2018 using Danish nationwide registries categorized into (no healthcare contact within 30 days) healthcare-associated (SAB &gt;48 hours hospital admission, hospitalization days,...
Methicillin-resistant and -susceptible Staphylococcus aureus (MRSA/MSSA) infections are a major global health-care problem. Bacteremia with S. exhibits high rates of morbidity mortality can cause complicated such as infective endocarditis (IE). The emerging resistance profile is worrisome, several international agencies have appealed for new treatment approaches to be developed.Daptomycin presents rapid bactericidal effect against MRSA has been considered at least effective vancomycin in...
We present a 54-year-old woman with systemic lupus erythematosus (SLE), fever, pericardial effusion and mitral valve vegetation. (18)F-Fluorodesoxyglucose positron emission tomography CT ((18)F-FDG-PET-CT) showed very high accumulation of the isotope at valve. The patient underwent cardiothoracic surgery pathologic examinations characteristic morphology Libman-Sacks vegetations. All microbiological including blood cultures, microscopy, culture 16s PCR were negative diagnosis endocarditis was...